m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00301)
Target Name Transcription factor Jun (c-Jun/JUN)
Synonyms
Activator protein 1; AP1; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
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Gene Name JUN
Chromosomal Location 1p32.1
Family bZIP family; Jun subfamily
Function
Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells .
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Gene ID 3725
Uniprot ID
JUN_HUMAN
HGNC ID
HGNC:6204
Ensembl Gene ID
ENSG00000177606
KEGG ID
hsa:3725
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
JUN can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Protein virilizer homolog (VIRMA) [WRITER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between JUN and the regulator
Cell Line HeLa Homo sapiens
Regulation logFC: 1.80E+00 GSE102493
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary KIAA1429 played a key role in promoting gastric cancer by regulating Transcription factor Jun (c-Jun/JUN) expression in an m6A independent manner.
Target Regulation Up regulation
Responsed Disease Gastric cancer ICD-11: 2B72
 Disease Info 
Pathway Response Cell cycle hsa04110
Cell Process Arrest cell cycle at the S phase
In-vitro Model MGC-803 Gastric mucinous adenocarcinoma Homo sapiens CVCL_5334
SGC-7901 Gastric carcinoma Homo sapiens CVCL_0520
In-vivo Model Gastric cancer cell line MGC803 (shRNA-NC or shKIAA1429; 1 × 107) was injected subcutaneously into the armpit of BALB/c nude mice (5-week-old, male, n = 4 for each group). Tumor growth was monitored at 3-day intervals.
Gastric cancer [ICD-11: 2B72]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary KIAA1429 played a key role in promoting gastric cancer by regulating Transcription factor Jun (c-Jun/JUN) expression in an m6A independent manner.
Responsed Disease Gastric cancer [ICD-11: 2B72]
Target Regulator Protein virilizer homolog (VIRMA) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Cell cycle hsa04110
Cell Process Arrest cell cycle at the S phase
In-vitro Model MGC-803 Gastric mucinous adenocarcinoma Homo sapiens CVCL_5334
SGC-7901 Gastric carcinoma Homo sapiens CVCL_0520
In-vivo Model Gastric cancer cell line MGC803 (shRNA-NC or shKIAA1429; 1 × 107) was injected subcutaneously into the armpit of BALB/c nude mice (5-week-old, male, n = 4 for each group). Tumor growth was monitored at 3-day intervals.
References
Ref 1 KIAA1429 regulates cell proliferation by targeting c-Jun messenger RNA directly in gastric cancer. J Cell Physiol. 2020 Oct;235(10):7420-7432. doi: 10.1002/jcp.29645. Epub 2020 Feb 13.