m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00289)
Target Name Interferon-induced 54 kDa protein (IFIT2)
Synonyms
IFIT-2; ISG-54 K; Interferon-induced 54 kDa protein; IFI-54K; P54; CIG-42; G10P2; IFI54; ISG54
    Click to Show/Hide
Gene Name IFIT2
Chromosomal Location 10q23.31
Family IFIT family
Function
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
    Click to Show/Hide
Gene ID 3433
Uniprot ID
IFIT2_HUMAN
HGNC ID
HGNC:5409
Ensembl Gene ID
ENSG00000119922
KEGG ID
hsa:3433
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
IFIT2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Browse Drug
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line LNCaP cell line Homo sapiens
Treatment: shMETTL3 LNCaP cells
Control: shControl LNCaP cells
 GSE147884
Regulation
logFC: 9.21E-01
p-value: 1.94E-18
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 was upregulated and predicted poor prognosis of patients with intrahepatic cholangiocarcinoma(ICC). H3K4me3 activation-driven METTL3 transcription promotes ICC progression by YTHDF2-mediated Interferon-induced 54 kDa protein (IFIT2) mRNA degradation.
Target Regulation Down regulation
Responsed Disease Intrahepatic cholangiocarcinoma ICD-11: 2C12.10
 Disease Info 
In-vitro Model HuCC-T1 Intrahepatic cholangiocarcinoma Homo sapiens CVCL_0324
HCCC-9810 Intrahepatic cholangiocarcinoma Homo sapiens CVCL_6908
In-vivo Model 4-week-old female BALB/c nude mice were used for HuCC-T1 tumor xenograft models and 4-week-old female B-NDG mice (Biocytogen, Beijing, China) were used for HCCC-9810 tumor xenograft models. 1 × 107 HuCC-T1 or HCCC-9810 cells were resuspended in 100 ul PBS with Matrigel (1:1), and injected into the right flank of mice (n = 6/group).
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 was upregulated and predicted poor prognosis of patients with intrahepatic cholangiocarcinoma(ICC). H3K4me3 activation-driven METTL3 transcription promotes ICC progression by YTHDF2-mediated Interferon-induced 54 kDa protein (IFIT2) mRNA degradation.
Responsed Disease Intrahepatic cholangiocarcinoma [ICD-11: 2C12.10]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model HuCC-T1 Intrahepatic cholangiocarcinoma Homo sapiens CVCL_0324
HCCC-9810 Intrahepatic cholangiocarcinoma Homo sapiens CVCL_6908
In-vivo Model 4-week-old female BALB/c nude mice were used for HuCC-T1 tumor xenograft models and 4-week-old female B-NDG mice (Biocytogen, Beijing, China) were used for HCCC-9810 tumor xenograft models. 1 × 107 HuCC-T1 or HCCC-9810 cells were resuspended in 100 ul PBS with Matrigel (1:1), and injected into the right flank of mice (n = 6/group).
Melanoma [ICD-11: 2C30]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary In skin cutaneous melanoma, drug sensitivity analysis indicated that the high expression of Interferon-induced 54 kDa protein (IFIT2) was sensitive to dasatinib drug. The expressing levels of IFITs were found to be positively correlated with the level of immune cell infiltrates, immune biomarkers and m6A regulators.
Responsed Disease Melanoma of skin [ICD-11: 2C30.Z]
Responsed Drug Dasatinib Approved
 Drug Info 
Cell Process Cell apoptosis
Epithelial-mesenchymal transition
Cell cycle
Dasatinib [Approved]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response []
Response Summary In skin cutaneous melanoma, drug sensitivity analysis indicated that the high expression of Interferon-induced 54 kDa protein (IFIT2) was sensitive to dasatinib drug. The expressing levels of IFITs were found to be positively correlated with the level of immune cell infiltrates, immune biomarkers and m6A regulators.
Responsed Disease Melanoma of skin ICD-11: 2C30.Z
 Disease Info 
Cell Process Cell apoptosis
Epithelial-mesenchymal transition
Cell cycle
References
Ref 1 METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m(6)A-YTHDF2-dependent manner. Oncogene. 2022 Mar;41(11):1622-1633. doi: 10.1038/s41388-022-02185-1. Epub 2022 Jan 29.