m6A-centered Drug Response Information

General Information of the Drug (ID: M6ADRUG0042)
Name
Dasatinib
Synonyms
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
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Status Approved [1]
Structure
Formula
C22H26ClN7O2S
InChI
InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChIKey
ZBNZXTGUTAYRHI-UHFFFAOYSA-N
PubChem CID
3062316
TTD Drug ID
D0E6XR
DrugBank ID
DB01254
Full List of m6A Targets Related to This Drug
Interferon-induced 54 kDa protein (IFIT2)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Drug Response by This Target Gene [2]
Response Summary In skin cutaneous melanoma, drug sensitivity analysis indicated that the high expression of Interferon-induced 54 kDa protein (IFIT2) was sensitive to dasatinib drug. The expressing levels of IFITs were found to be positively correlated with the level of immune cell infiltrates, immune biomarkers and m6A regulators.
Responsed Disease Melanoma of skin ICD-11: 2C30.Z
 Disease Info 
Cell Process Cell apoptosis
Epithelial-mesenchymal transition
Cell cycle
References
Ref 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5678).
Ref 2 Comprehensive analysis of the prognosis and biological significance for IFIT family in skin cutaneous melanoma. Int Immunopharmacol. 2021 Dec;101(Pt A):108344. doi: 10.1016/j.intimp.2021.108344. Epub 2021 Nov 8.