m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00282)
Target Name Homeobox protein Hox-B4 (HOXB4)
Synonyms
Homeobox protein Hox-2.6; Homeobox protein Hox-2F; HOX2F
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Gene Name HOXB4
Chromosomal Location 17q21.32
Family Antp homeobox family; Deformed subfamily
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
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Gene ID 3214
Uniprot ID
HXB4_HUMAN
HGNC ID
HGNC:5115
Ensembl Gene ID
ENSG00000182742
KEGG ID
hsa:3214
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
HOXB4 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by IGF2BP1
Cell Line PANC-1 cell line Homo sapiens
Treatment: siIGF2BP1 PANC-1 cells
Control: siControl PANC-1 cells
 GSE161087
Regulation
logFC: -9.62E-01
p-value: 3.85E-02
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary IGF2BP1 decreases leukemia cells' tumorigenicity, promotes myeloid differentiation, increases leukemia cell death, and sensitizes acute myeloid leukemia cells to chemotherapeutic drugs. IGF2BP1 affects proliferation and tumorigenic potential of leukemia cells through critical regulators of self-renewal Homeobox protein Hox-B4 (HOXB4) and MYB and through regulation of expression of the aldehyde dehydrogenase, ALDH1A1.
Target Regulation Up regulation
Responsed Disease Acute myeloid leukaemia ICD-11: 2A60
 Disease Info 
In-vitro Model MOLT-16 T acute lymphoblastic leukemia Homo sapiens CVCL_1424
Reh B acute lymphoblastic leukemia Homo sapiens CVCL_1650
SKNO-1 Myeloid leukemia with maturation Homo sapiens CVCL_2196
Tanoue B acute lymphoblastic leukemia Homo sapiens CVCL_1852
In-vivo Model For the engraftment experiments, 1×103 1×106 cells were injected into tail veins of non-irradiated 6-10 week-old female mice in 100 uL of DPBS per mouse. No blinding or randomization was applied to mice experiments. Routinely, each in vivo experiment was performed with three technical replicates (three mice per group) and independently repeated two to three times for each cell line.
Acute myeloid leukaemia [ICD-11: 2A60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary IGF2BP1 decreases leukemia cells' tumorigenicity, promotes myeloid differentiation, increases leukemia cell death, and sensitizes acute myeloid leukemia cells to chemotherapeutic drugs. IGF2BP1 affects proliferation and tumorigenic potential of leukemia cells through critical regulators of self-renewal Homeobox protein Hox-B4 (HOXB4) and MYB and through regulation of expression of the aldehyde dehydrogenase, ALDH1A1.
Responsed Disease Acute myeloid leukaemia [ICD-11: 2A60]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) READER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model MOLT-16 T acute lymphoblastic leukemia Homo sapiens CVCL_1424
Reh B acute lymphoblastic leukemia Homo sapiens CVCL_1650
SKNO-1 Myeloid leukemia with maturation Homo sapiens CVCL_2196
Tanoue B acute lymphoblastic leukemia Homo sapiens CVCL_1852
In-vivo Model For the engraftment experiments, 1×103 1×106 cells were injected into tail veins of non-irradiated 6-10 week-old female mice in 100 uL of DPBS per mouse. No blinding or randomization was applied to mice experiments. Routinely, each in vivo experiment was performed with three technical replicates (three mice per group) and independently repeated two to three times for each cell line.
References
Ref 1 RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1. Leukemia. 2020 May;34(5):1354-1363. doi: 10.1038/s41375-019-0656-9. Epub 2019 Nov 25.