m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00278)
Target Name Hepatocyte nuclear factor 1-alpha (HNF1A/TCF1)
Synonyms
HNF-1-alpha; HNF-1A; Liver-specific transcription factor LF-B1; LFB1; Transcription factor 1; TCF-1; TCF1
    Click to Show/Hide
Gene Name HNF1A
Chromosomal Location 12q24.31
Family HNF1 homeobox family
Function
Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity).
    Click to Show/Hide
Gene ID 6927
Uniprot ID
HNF1A_HUMAN
HGNC ID
HGNC:11621
Ensembl Gene ID
ENSG00000135100
KEGG ID
hsa:6927
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
HNF1A can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line mouse embryonic stem cells Mus musculus
Treatment: METTL3-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: -1.64E+00
p-value: 4.47E-50
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between HNF1A and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 6.55E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Silence of METTL3 inhibited migratory ability and Wnt activity in TPC-1 cells. METTL3 positively regulated the enrichment abundance of Hepatocyte nuclear factor 1-alpha (HNF1A/TCF1) in anti-IGF2BP2. TCF1 was responsible for METTL3-regulated thyroid carcinoma progression via the m6A methylation.
Target Regulation Up regulation
Responsed Disease Thyroid Cancer ICD-11: 2D10
 Disease Info 
Pathway Response Wnt signaling pathway hsa04310
Cell Process Cell migratory
In-vitro Model B-CPAP Thyroid gland carcinoma Homo sapiens CVCL_0153
Nthy-ori 3-1 Normal Homo sapiens CVCL_2659
TPC-1 Thyroid gland papillary carcinoma Homo sapiens CVCL_6298
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Silence of METTL3 inhibited migratory ability and Wnt activity in TPC-1 cells. METTL3 positively regulated the enrichment abundance of Hepatocyte nuclear factor 1-alpha (HNF1A/TCF1) in anti-IGF2BP2. TCF1 was responsible for METTL3-regulated thyroid carcinoma progression via the m6A methylation.
Target Regulation Up regulation
Responsed Disease Thyroid Cancer ICD-11: 2D10
 Disease Info 
Pathway Response Wnt signaling pathway hsa04310
Cell Process Cell migratory
In-vitro Model B-CPAP Thyroid gland carcinoma Homo sapiens CVCL_0153
Nthy-ori 3-1 Normal Homo sapiens CVCL_2659
TPC-1 Thyroid gland papillary carcinoma Homo sapiens CVCL_6298
Thyroid Cancer [ICD-11: 2D10]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Silence of METTL3 inhibited migratory ability and Wnt activity in TPC-1 cells. METTL3 positively regulated the enrichment abundance of Hepatocyte nuclear factor 1-alpha (HNF1A/TCF1) in anti-IGF2BP2. TCF1 was responsible for METTL3-regulated thyroid carcinoma progression via the m6A methylation.
Responsed Disease Thyroid Cancer [ICD-11: 2D10]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Wnt signaling pathway hsa04310
Cell Process Cell migratory
In-vitro Model B-CPAP Thyroid gland carcinoma Homo sapiens CVCL_0153
Nthy-ori 3-1 Normal Homo sapiens CVCL_2659
TPC-1 Thyroid gland papillary carcinoma Homo sapiens CVCL_6298
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary Silence of METTL3 inhibited migratory ability and Wnt activity in TPC-1 cells. METTL3 positively regulated the enrichment abundance of Hepatocyte nuclear factor 1-alpha (HNF1A/TCF1) in anti-IGF2BP2. TCF1 was responsible for METTL3-regulated thyroid carcinoma progression via the m6A methylation.
Responsed Disease Thyroid Cancer [ICD-11: 2D10]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Wnt signaling pathway hsa04310
Cell Process Cell migratory
In-vitro Model B-CPAP Thyroid gland carcinoma Homo sapiens CVCL_0153
Nthy-ori 3-1 Normal Homo sapiens CVCL_2659
TPC-1 Thyroid gland papillary carcinoma Homo sapiens CVCL_6298
References
Ref 1 Progression of Thyroid Carcinoma Is Promoted by the m6A Methyltransferase METTL3 Through Regulating m(6)A Methylation on TCF1. Onco Targets Ther. 2020 Feb 21;13:1605-1612. doi: 10.2147/OTT.S234751. eCollection 2020.