m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00275)
Target Name Adenosine 5'-monophosphoramidase HINT2 (HINT2)
Synonyms
HINT-3; HIT-17kDa; Histidine triad nucleotide-binding protein 2, mitochondrial; HINT-2; PKCI-1-related HIT protein
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Gene Name HINT2
Chromosomal Location 9p13.3
Family HINT family
Function
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro. May be involved in steroid biosynthesis. May play a role in apoptosis.
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Gene ID 84681
Uniprot ID
HINT2_HUMAN
HGNC ID
HGNC:18344
Ensembl Gene ID
ENSG00000137133
KEGG ID
hsa:84681
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
HINT2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 1 (YTHDF1) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF1
Cell Line AGS cell line Homo sapiens
Treatment: shYTHDF1 AGS
Control: shControl AGS
 GSE159425
Regulation
logFC: 8.82E-01
p-value: 1.64E-04
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary YTHDF1 promoted the translation of methylated Adenosine 5'-monophosphoramidase HINT2 (HINT2) mRNA, a tumor suppressor in ocular melanoma.
Target Regulation Up regulation
Responsed Disease Melanoma ICD-11: 2C30
 Disease Info 
In-vitro Model CM2005.1 Conjunctival melanoma Homo sapiens CVCL_M592
CRMM-1 Conjunctival melanoma Homo sapiens CVCL_M593
HEK293T Normal Homo sapiens CVCL_0063
OCM-1 Amelanotic melanoma Homo sapiens CVCL_6934
OCM-1A Amelanotic melanoma Homo sapiens CVCL_6935
OM431 Uveal melanoma Homo sapiens CVCL_J308
PIG1 Normal Homo sapiens CVCL_S410
In-vivo Model Approximately 1 × 106 melanoma cells from each group were injected subcutaneously into the right side of the abdomen of BALB/c nude mice (male, 6 weeks old).
Melanoma [ICD-11: 2C30]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary YTHDF1 promoted the translation of methylated Adenosine 5'-monophosphoramidase HINT2 (HINT2) mRNA, a tumor suppressor in ocular melanoma.
Responsed Disease Melanoma [ICD-11: 2C30]
Target Regulator YTH domain-containing family protein 1 (YTHDF1) READER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model CM2005.1 Conjunctival melanoma Homo sapiens CVCL_M592
CRMM-1 Conjunctival melanoma Homo sapiens CVCL_M593
HEK293T Normal Homo sapiens CVCL_0063
OCM-1 Amelanotic melanoma Homo sapiens CVCL_6934
OCM-1A Amelanotic melanoma Homo sapiens CVCL_6935
OM431 Uveal melanoma Homo sapiens CVCL_J308
PIG1 Normal Homo sapiens CVCL_S410
In-vivo Model Approximately 1 × 106 melanoma cells from each group were injected subcutaneously into the right side of the abdomen of BALB/c nude mice (male, 6 weeks old).
References
Ref 1 m(6)A modification suppresses ocular melanoma through modulating HINT2 mRNA translation. Mol Cancer. 2019 Nov 14;18(1):161. doi: 10.1186/s12943-019-1088-x.