m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00270)
Target Name E3 ubiquitin-protein ligase Hakai (CBLL1)
Synonyms
Casitas B-lineage lymphoma-transforming sequence-like protein 1; c-Cbl-like protein 1; RING finger protein 188; RING-type E3 ubiquitin transferase Hakai; HAKAI; RNF188
    Click to Show/Hide
Gene Name CBLL1
Chromosomal Location 7q22.3
Family Hakai family
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown.
    Click to Show/Hide
Gene ID 79872
Uniprot ID
HAKAI_HUMAN
HGNC ID
HGNC:21225
Ensembl Gene ID
ENSG00000105879
KEGG ID
hsa:79872
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
CBLL1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Protein virilizer homolog (VIRMA) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary KIAA1429 had the highest mutation frequency. Higher E3 ubiquitin-protein ligase Hakai (CBLL1) expression was associated with a better prognosis in breast cancer than lower CBLL1 expression.
Target Regulation Up regulation
Responsed Disease Breast cancer ICD-11: 2C60
 Disease Info 
Cell Process Cell apoptosis
Breast cancer [ICD-11: 2C60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary KIAA1429 had the highest mutation frequency. Higher E3 ubiquitin-protein ligase Hakai (CBLL1) expression was associated with a better prognosis in breast cancer than lower CBLL1 expression.
Responsed Disease Breast cancer [ICD-11: 2C60]
Target Regulator Protein virilizer homolog (VIRMA) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell apoptosis
References
Ref 1 Expression and clinical prognostic value of m6A RNA methylation modification in breast cancer. Biomark Res. 2021 Apr 29;9(1):28. doi: 10.1186/s40364-021-00285-w.