m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00265)
Target Name Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)
Synonyms
GATA-binding factor 3
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Gene Name GATA3
Chromosomal Location 10p14
Function
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity).
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Gene ID 2625
Uniprot ID
GATA3_HUMAN
HGNC ID
HGNC:4172
Ensembl Gene ID
ENSG00000107485
KEGG ID
hsa:2625
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
GATA3 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Protein virilizer homolog (VIRMA) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary KIAA1429 induced m6A methylation on the 3' UTR of Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) pre-mRNA, leading to the separation of the RNA-binding protein HuR and the degradation of GATA3 pre-mRNA. KIAA1429 was considerably upregulated in Hepatocellular carcinoma tissues.
Target Regulation Down regulation
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Cell Process Cell proliferation and metastasis
In-vitro Model HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
HEK293T Normal Homo sapiens CVCL_0063
Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
Huh-7 Adult hepatocellular carcinoma Homo sapiens CVCL_0336
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm Homo sapiens CVCL_0525
SNU-182 Adult hepatocellular carcinoma Homo sapiens CVCL_0090
SNU-449 Adult hepatocellular carcinoma Homo sapiens CVCL_0454
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary KIAA1429 induced m6A methylation on the 3' UTR of Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) pre-mRNA, leading to the separation of the RNA-binding protein HuR and the degradation of GATA3 pre-mRNA. KIAA1429 was considerably upregulated in Hepatocellular carcinoma tissues.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator Protein virilizer homolog (VIRMA) WRITER
 Regulator Info 
Target Regulation Down regulation
Cell Process Cell proliferation and metastasis
In-vitro Model HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
HEK293T Normal Homo sapiens CVCL_0063
Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
Huh-7 Adult hepatocellular carcinoma Homo sapiens CVCL_0336
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm Homo sapiens CVCL_0525
SNU-182 Adult hepatocellular carcinoma Homo sapiens CVCL_0090
SNU-449 Adult hepatocellular carcinoma Homo sapiens CVCL_0454
References
Ref 1 KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3. Mol Cancer. 2019 Dec 19;18(1):186. doi: 10.1186/s12943-019-1106-z.