m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00242)
Target Name Epithelial membrane protein 3 (EMP3)
Synonyms
EMP-3; Hematopoietic neural membrane protein 1; HNMP-1; Protein YMP; YMP
    Click to Show/Hide
Gene Name EMP3
Chromosomal Location 19q13.33
Family PMP-22/EMP/MP20 family
Function
Probably involved in cell proliferation and cell-cell interactions.
    Click to Show/Hide
Gene ID 2014
Uniprot ID
EMP3_HUMAN
HGNC ID
HGNC:3335
Ensembl Gene ID
ENSG00000142227
KEGG ID
hsa:2014
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
EMP3 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Browse Drug
YTH domain-containing protein 1 (YTHDC1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Epithelial membrane protein 3 (EMP3) blocks Akt-mTOR signaling activation and induces autophagy. EMP3 downregulates YTHDC1, which at least in part mediates the effects of EMP3 on breast cancer cells. EMP3 sensitizes breast cancer cells to the DNA-damaging drug Adriamycin. EMP3 downregulation can be responsible for breast cancer chemoresistance.
Target Regulation Down regulation
Responsed Disease Breast cancer ICD-11: 2C60
 Disease Info 
Responsed Drug Doxil Approved
 Drug Info 
Pathway Response Nucleotide excision repair hsa03420
mTOR signaling pathway hsa04150
PI3K-Akt signaling pathway hsa04151
Cell Process DNA repair
In-vitro Model BT-474 Invasive breast carcinoma Homo sapiens CVCL_0179
Hs 578T Invasive breast carcinoma Homo sapiens CVCL_0332
MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
MDA-MB-231 Breast adenocarcinoma Homo sapiens CVCL_0062
SK-BR-3 Breast adenocarcinoma Homo sapiens CVCL_0033
Breast cancer [ICD-11: 2C60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Epithelial membrane protein 3 (EMP3) blocks Akt-mTOR signaling activation and induces autophagy. EMP3 downregulates YTHDC1, which at least in part mediates the effects of EMP3 on breast cancer cells. EMP3 sensitizes breast cancer cells to the DNA-damaging drug Adriamycin. EMP3 downregulation can be responsible for breast cancer chemoresistance.
Responsed Disease Breast cancer [ICD-11: 2C60]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Target Regulation Down regulation
Responsed Drug Doxil Approved
 Drug Info 
Pathway Response Nucleotide excision repair hsa03420
mTOR signaling pathway hsa04150
PI3K-Akt signaling pathway hsa04151
Cell Process DNA repair
In-vitro Model BT-474 Invasive breast carcinoma Homo sapiens CVCL_0179
Hs 578T Invasive breast carcinoma Homo sapiens CVCL_0332
MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
MDA-MB-231 Breast adenocarcinoma Homo sapiens CVCL_0062
SK-BR-3 Breast adenocarcinoma Homo sapiens CVCL_0033
Doxil [Approved]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response [1]
Response Summary Epithelial membrane protein 3 (EMP3) blocks Akt-mTOR signaling activation and induces autophagy. EMP3 downregulates YTHDC1, which at least in part mediates the effects of EMP3 on breast cancer cells. EMP3 sensitizes breast cancer cells to the DNA-damaging drug Adriamycin. EMP3 downregulation can be responsible for breast cancer chemoresistance.
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Target Regulation Down regulation
Responsed Disease Breast cancer ICD-11: 2C60
 Disease Info 
Pathway Response Nucleotide excision repair hsa03420
mTOR signaling pathway hsa04150
PI3K-Akt signaling pathway hsa04151
Cell Process DNA repair
In-vitro Model BT-474 Invasive breast carcinoma Homo sapiens CVCL_0179
Hs 578T Invasive breast carcinoma Homo sapiens CVCL_0332
MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
MDA-MB-231 Breast adenocarcinoma Homo sapiens CVCL_0062
SK-BR-3 Breast adenocarcinoma Homo sapiens CVCL_0033
References
Ref 1 EMP3 negatively modulates breast cancer cell DNA replication, DNA damage repair, and stem-like properties. Cell Death Dis. 2021 Sep 12;12(9):844. doi: 10.1038/s41419-021-04140-6.