m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00233)
Target Name Dual specificity protein phosphatase 6 (DUSP6)
Synonyms
Dual specificity protein phosphatase PYST1; Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3; MKP3; PYST1
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Gene Name DUSP6
Chromosomal Location 12q21.33
Family protein-tyrosine phosphatase family; Non-receptor class dual specificity subfamily
Function
Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors.
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Gene ID 1848
Uniprot ID
DUS6_HUMAN
HGNC ID
HGNC:3072
Ensembl Gene ID
ENSG00000139318
KEGG ID
hsa:1848
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
DUSP6 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Wilms tumor 1-associating protein (WTAP) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by WTAP
Cell Line mouse embryonic stem cells Mus musculus
Treatment: WTAP-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: -6.99E-01
p-value: 7.61E-15
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary m6A methyltransferase Wilms' tumor 1-associated protein facilitates cell proliferation and cisplatin resistance in NK/T cell lymphoma by regulating dual-specificity phosphatases 6 expression via m6A RNA methylation. WTAP enhanced Dual specificity protein phosphatase 6 (DUSP6) expression by increasing m6A levels of DUSP6 mRNA transcript, leading to oncogenic functions in NKTCL.
Target Regulation Up regulation
Responsed Disease Malignant haematopoietic neoplasm ICD-11: 2B33
 Disease Info 
Responsed Drug Cisplatin Approved
 Drug Info 
Cell Process Cell apoptosis
In-vitro Model Normal NK cells (CD3-negative lymphocytes)
SNK-6 Nasal type extranodal NK/T-cell lymphoma Homo sapiens CVCL_A673
YTS Lymphoblastic leukemia/lymphoma Homo sapiens CVCL_D324
Malignant haematopoietic neoplasm [ICD-11: 2B33]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary m6A methyltransferase Wilms' tumor 1-associated protein facilitates cell proliferation and cisplatin resistance in NK/T cell lymphoma by regulating dual-specificity phosphatases 6 expression via m6A RNA methylation. WTAP enhanced Dual specificity protein phosphatase 6 (DUSP6) expression by increasing m6A levels of DUSP6 mRNA transcript, leading to oncogenic functions in NKTCL.
Responsed Disease Malignant haematopoietic neoplasm [ICD-11: 2B33]
Target Regulator Wilms tumor 1-associating protein (WTAP) WRITER
 Regulator Info 
Target Regulation Up regulation
Responsed Drug Cisplatin Approved
 Drug Info 
Cell Process Cell apoptosis
In-vitro Model Normal NK cells (CD3-negative lymphocytes)
SNK-6 Nasal type extranodal NK/T-cell lymphoma Homo sapiens CVCL_A673
YTS Lymphoblastic leukemia/lymphoma Homo sapiens CVCL_D324
Cisplatin [Approved]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response [1]
Response Summary m6A methyltransferase Wilms' tumor 1-associated protein facilitates cell proliferation and cisplatin resistance in NK/T cell lymphoma by regulating dual-specificity phosphatases 6 expression via m6A RNA methylation. WTAP enhanced Dual specificity protein phosphatase 6 (DUSP6) expression by increasing m6A levels of DUSP6 mRNA transcript, leading to oncogenic functions in NKTCL.
Target Regulator Wilms tumor 1-associating protein (WTAP) WRITER
 Regulator Info 
Target Regulation Up regulation
Responsed Disease Malignant haematopoietic neoplasm ICD-11: 2B33
 Disease Info 
Cell Process Cell apoptosis
In-vitro Model Normal NK cells (CD3-negative lymphocytes)
SNK-6 Nasal type extranodal NK/T-cell lymphoma Homo sapiens CVCL_A673
YTS Lymphoblastic leukemia/lymphoma Homo sapiens CVCL_D324
References
Ref 1 m6A methyltransferase Wilms' tumor 1-associated protein facilitates cell proliferation and cisplatin resistance in NK/T cell lymphoma by regulating dual-specificity phosphatases 6 expression via m6A RNA methylation. IUBMB Life. 2021 Jan;73(1):108-117. doi: 10.1002/iub.2410. Epub 2020 Nov 17.