m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00230)
Target Name Developmentally-regulated GTP-binding protein 1 (DRG1)
Synonyms
DRG-1; Neural precursor cell expressed developmentally down-regulated protein 3; NEDD-3; Translation factor GTPase DRG1; TRAFAC GTPase DRG1; NEDD3
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Gene Name DRG1
Chromosomal Location 22q12.2
Family TRAFAC class OBG-HflX-like GTPase superfamily; OBG GTPase family
Function
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions.
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Gene ID 4733
Uniprot ID
DRG1_HUMAN
HGNC ID
HGNC:3029
Ensembl Gene ID
ENSG00000185721
KEGG ID
hsa:4733
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
DRG1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Pancreatic islets Mus musculus
Treatment: Mettl3 knockout mice
Control: Mettl3 flox/flox mice
 GSE155612
Regulation
logFC: 6.62E-01
p-value: 3.32E-04
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between DRG1 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 1.01E+01 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ELAVL1 knockdown impaired the stability of DRG1 mRNA, thereby reducing both the mRNA and protein levels of Developmentally-regulated GTP-binding protein 1 (DRG1). In all, DRG1 exerted tumorigenic effects in osteosarcoma, and the up-regulation of DRG1 in OS was induced by METTL3 and ELAVL1 in an m6A-dependent manner.
Target Regulation Up regulation
Responsed Disease Osteosarcoma ICD-11: 2B51
 Disease Info 
Cell Process Cell cycle
Cell apoptosis
In-vitro Model 143B Osteosarcoma Homo sapiens CVCL_2270
hFOB 1.19 Normal Homo sapiens CVCL_3708
MG-63 Osteosarcoma Homo sapiens CVCL_0426
SaOS-2 Osteosarcoma Homo sapiens CVCL_0548
U2OS Osteosarcoma Homo sapiens CVCL_0042
ELAV-like protein 1 (ELAVL1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ELAVL1 knockdown impaired the stability of DRG1 mRNA, thereby reducing both the mRNA and protein levels of Developmentally-regulated GTP-binding protein 1 (DRG1). In all, DRG1 exerted tumorigenic effects in osteosarcoma, and the up-regulation of DRG1 in OS was induced by METTL3 and ELAVL1 in an m6A-dependent manner.
Target Regulation Up regulation
Responsed Disease Osteosarcoma ICD-11: 2B51
 Disease Info 
Cell Process Cell cycle
Cell apoptosis
In-vitro Model 143B Osteosarcoma Homo sapiens CVCL_2270
hFOB 1.19 Normal Homo sapiens CVCL_3708
MG-63 Osteosarcoma Homo sapiens CVCL_0426
SaOS-2 Osteosarcoma Homo sapiens CVCL_0548
U2OS Osteosarcoma Homo sapiens CVCL_0042
Osteosarcoma [ICD-11: 2B51]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary ELAVL1 knockdown impaired the stability of DRG1 mRNA, thereby reducing both the mRNA and protein levels of Developmentally-regulated GTP-binding protein 1 (DRG1). In all, DRG1 exerted tumorigenic effects in osteosarcoma, and the up-regulation of DRG1 in OS was induced by METTL3 and ELAVL1 in an m6A-dependent manner.
Responsed Disease Osteosarcoma [ICD-11: 2B51]
Target Regulator ELAV-like protein 1 (ELAVL1) READER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell cycle
Cell apoptosis
In-vitro Model 143B Osteosarcoma Homo sapiens CVCL_2270
hFOB 1.19 Normal Homo sapiens CVCL_3708
MG-63 Osteosarcoma Homo sapiens CVCL_0426
SaOS-2 Osteosarcoma Homo sapiens CVCL_0548
U2OS Osteosarcoma Homo sapiens CVCL_0042
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary ELAVL1 knockdown impaired the stability of DRG1 mRNA, thereby reducing both the mRNA and protein levels of Developmentally-regulated GTP-binding protein 1 (DRG1). In all, DRG1 exerted tumorigenic effects in osteosarcoma, and the up-regulation of DRG1 in OS was induced by METTL3 and ELAVL1 in an m6A-dependent manner.
Responsed Disease Osteosarcoma [ICD-11: 2B51]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell cycle
Cell apoptosis
In-vitro Model 143B Osteosarcoma Homo sapiens CVCL_2270
hFOB 1.19 Normal Homo sapiens CVCL_3708
MG-63 Osteosarcoma Homo sapiens CVCL_0426
SaOS-2 Osteosarcoma Homo sapiens CVCL_0548
U2OS Osteosarcoma Homo sapiens CVCL_0042
References
Ref 1 m6A-dependent up-regulation of DRG1 by METTL3 and ELAVL1 promotes growth, migration, and colony formation in osteosarcoma. Biosci Rep. 2020 Apr 30;40(4):BSR20200282. doi: 10.1042/BSR20200282.