m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00207)
Target Name G1/S-specific cyclin-D2 (CCND2)
Gene Name CCND2
Chromosomal Location 12p13.32
Family cyclin family; Cyclin D subfamily
Function
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
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Gene ID 894
Uniprot ID
CCND2_HUMAN
HGNC ID
HGNC:1583
Ensembl Gene ID
ENSG00000118971
KEGG ID
hsa:894
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
CCND2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing protein 2 (YTHDC2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Knockdown of YTHDC2 substantially promoted the proliferation rate of esophageal squamous cell carcinoma cells by affecting several cancer-related signaling pathways.
Target Regulation Up regulation
Responsed Disease Esophageal squamous cell carcinoma ICD-11: 2B70.1
 Disease Info 
Pathway Response p53 signaling pathway hsa04115
NF-kappa B signaling pathway hsa04064
JAK-STAT signaling pathway hsa04630
Cell Process Genetic variants
In-vitro Model KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
KYSE-30 Esophageal squamous cell carcinoma Homo sapiens CVCL_1351
Oral cavity/oesophagus/stomach in situ carcinoma [ICD-11: 2E60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Knockdown of YTHDC2 substantially promoted the proliferation rate of esophageal squamous cell carcinoma cells by affecting several cancer-related signaling pathways.
Responsed Disease Esophageal squamous cell carcinoma [ICD-11: 2B70.1]
Target Regulator YTH domain-containing protein 2 (YTHDC2) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response p53 signaling pathway hsa04115
NF-kappa B signaling pathway hsa04064
JAK-STAT signaling pathway hsa04630
Cell Process Genetic variants
In-vitro Model KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
KYSE-30 Esophageal squamous cell carcinoma Homo sapiens CVCL_1351
References
Ref 1 Genetic variants in m6A modification genes are associated with esophageal squamous-cell carcinoma in the Chinese population. Carcinogenesis. 2020 Jul 10;41(6):761-768. doi: 10.1093/carcin/bgaa012.