m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00187)
Target Name Autophagy-related protein 2 homolog A (ATG2A)
Synonyms
KIAA0404
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Gene Name ATG2A
Chromosomal Location 11q13.1
Family ATG2 family
Function
Lipid transfer protein involved in autophagosome assembly. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes . Also regulates lipid droplets morphology and distribution within the cell.
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Gene ID 23130
Uniprot ID
ATG2A_HUMAN
HGNC ID
HGNC:29028
Ensembl Gene ID
ENSG00000110046
KEGG ID
hsa:23130
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
ATG2A can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 1 (YTHDF1) [READER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between ATG2A and the regulator
Cell Line Hela Homo sapiens
Regulation logFC: 2.31E+00 GSE63591
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary HIF-1-alpha-induced YTHDF1 expression was associated with hypoxia-induced autophagy and autophagy-related hepatocellular carcinoma progression via promoting translation of autophagy-related genes Autophagy-related protein 2 homolog A (ATG2A) and ATG14 in a m6A-dependent manner.
Target Regulation Up regulation
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Pathway Response Autophagy hsa04140
HIF-1 signaling pathway hsa04066
Cell Process Cell proliferation
Cell migration
Cell invasion
Cell autophagy
In-vitro Model Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
Huh-7 Adult hepatocellular carcinoma Homo sapiens CVCL_0336
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model HCC cells (1 × 106/100 uL PBS) were administered to 4-week-old female BALB/c nude mice by subcutaneous injection (n = 6).
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary HIF-1-alpha-induced YTHDF1 expression was associated with hypoxia-induced autophagy and autophagy-related hepatocellular carcinoma progression via promoting translation of autophagy-related genes Autophagy-related protein 2 homolog A (ATG2A) and ATG14 in a m6A-dependent manner.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator YTH domain-containing family protein 1 (YTHDF1) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Autophagy hsa04140
HIF-1 signaling pathway hsa04066
Cell Process Cell proliferation
Cell migration
Cell invasion
Cell autophagy
In-vitro Model Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
Huh-7 Adult hepatocellular carcinoma Homo sapiens CVCL_0336
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model HCC cells (1 × 106/100 uL PBS) were administered to 4-week-old female BALB/c nude mice by subcutaneous injection (n = 6).
References
Ref 1 HIF-1Alpha-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation. Signal Transduct Target Ther. 2021 Feb 23;6(1):76. doi: 10.1038/s41392-020-00453-8.