m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00176)
Target Name RAC-gamma serine/threonine-protein kinase (AKT3)
Synonyms
Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2; PKBG
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Gene Name AKT3
Chromosomal Location 1q43-q44
Family protein kinase superfamily; AGC Ser/Thr protein kinase family; RAC subfamily
Function
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
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Gene ID 10000
Uniprot ID
AKT3_HUMAN
HGNC ID
HGNC:393
Ensembl Gene ID
ENSG00000117020; ENSG00000275199
KEGG ID
hsa:10000
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
AKT3 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by HNRNPA2B1
Cell Line c2c12 cell line Mus musculus
Treatment: HNRNPA2B1 knockout c2c12 cells
Control: WT c2c12 cells
 GSE152467
Regulation
logFC: -6.81E-01
p-value: 1.74E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary m6A-dependent effect of HNRNPA2B1 on regulating AKT signaling pathway and the correlation between HNRNPA2B1 and multiple myeloma cell growth. HNRNPA2B1 recognized the m6A sites of ILF3 and enhanced the stability of ILF3 mRNA transcripts, while RAC-gamma serine/threonine-protein kinase (AKT3) downregulation by siRNA abrogated the cellular proliferation induced by HNRNPA2B1 overexpression.
Target Regulation Up regulation
Responsed Disease Multiple myeloma ICD-11: 2A83.1
 Disease Info 
Pathway Response Apoptosis hsa04210
Cell Process Cell proliferation
Cell apoptosis
In-vitro Model NCI-H929 Plasma cell myeloma Homo sapiens CVCL_1600
Multiple myeloma [ICD-11: 2A83]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary m6A-dependent effect of HNRNPA2B1 on regulating AKT signaling pathway and the correlation between HNRNPA2B1 and multiple myeloma cell growth. HNRNPA2B1 recognized the m6A sites of ILF3 and enhanced the stability of ILF3 mRNA transcripts, while RAC-gamma serine/threonine-protein kinase (AKT3) downregulation by siRNA abrogated the cellular proliferation induced by HNRNPA2B1 overexpression.
Responsed Disease Multiple myeloma [ICD-11: 2A83.1]
Target Regulator Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Apoptosis hsa04210
Cell Process Cell proliferation
Cell apoptosis
In-vitro Model NCI-H929 Plasma cell myeloma Homo sapiens CVCL_1600
References
Ref 1 HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA. J Hematol Oncol. 2021 Apr 1;14(1):54. doi: 10.1186/s13045-021-01066-6.