m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00151)
Target Name Deleted in lymphocytic leukemia 2 (DLEU2/LINC00022)
Synonyms
DLEU2; DLB2BCMSUNRFP2OS; ret finger protein 2 opposite strand; deleted in lymphocytic leukemia, 2; deleted in lymphocytic leukemia 2 (non-protein coding); LEU2; TRIM13OS; NCRNA00022; LINC00022; MIR15AHG; non-protein coding RNA 22; long intergenic non-protein coding RNA 22; mir-15a-16-1 cluster host gene (non-protein coding)
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Gene Name DLEU2
Chromosomal Location 13q14.2
Family Long non-coding RNAs with non-systematic symbols
Gene ID 8847
HGNC ID
HGNC:13748
Ensembl Gene ID
ENSG00000231607
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
DLEU2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF2
Cell Line Human umbilical cord blood CD34+ cells Homo sapiens
Treatment: YTHDF2 knockdown UCB CD34+ cells
Control: Wild type UCB CD34+ cells
 GSE107956
Regulation
logFC: -6.80E-01
p-value: 2.37E-05
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The elevated FTO in esophageal squamous cell carcinoma decreased m6A methylation of LINC00022 transcript, leading to the inhibition of Deleted in lymphocytic leukemia 2 (DLEU2/LINC00022) decay via the m6A reader YTHDF2.
Target Regulation Down regulation
Responsed Disease Esophageal squamous cell carcinoma ICD-11: 2B70.1
 Disease Info 
Pathway Response Cell cycle hsa04110
Ubiquitin mediated proteolysis hsa04120
Cell Process Ubiquitination degradation
Cell apoptosis
Decreased G0/G1 phase
In-vitro Model HET-1A Normal Homo sapiens CVCL_3702
KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
KYSE-450 Esophageal squamous cell carcinoma Homo sapiens CVCL_1353
KYSE-70 Esophageal squamous cell carcinoma Homo sapiens CVCL_1356
TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
In-vivo Model The number of cells inoculated in each mouse was 4 × 106, 1 × 106, 2 × 106 and 1 × 106, respectively.
Fat mass and obesity-associated protein (FTO) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The elevated FTO in esophageal squamous cell carcinoma decreased m6A methylation of Deleted in lymphocytic leukemia 2 (DLEU2/LINC00022) transcript, leading to the inhibition of LINC00022 decay via the m6A reader YTHDF2.
Target Regulation Down regulation
Responsed Disease Esophageal squamous cell carcinoma ICD-11: 2B70.1
 Disease Info 
Pathway Response Cell cycle hsa04110
Ubiquitin mediated proteolysis hsa04120
Cell Process Ubiquitination degradation
Cell apoptosis
Decreased G0/G1 phase
In-vitro Model HET-1A Normal Homo sapiens CVCL_3702
KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
KYSE-450 Esophageal squamous cell carcinoma Homo sapiens CVCL_1353
KYSE-70 Esophageal squamous cell carcinoma Homo sapiens CVCL_1356
TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
In-vivo Model The number of cells inoculated in each mouse was 4 × 106, 1 × 106, 2 × 106 and 1 × 106, respectively.
Oral cavity/oesophagus/stomach in situ carcinoma [ICD-11: 2E60]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The elevated FTO in esophageal squamous cell carcinoma decreased m6A methylation of Deleted in lymphocytic leukemia 2 (DLEU2/LINC00022) transcript, leading to the inhibition of LINC00022 decay via the m6A reader YTHDF2.
Responsed Disease Esophageal squamous cell carcinoma [ICD-11: 2B70.1]
Target Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Cell cycle hsa04110
Ubiquitin mediated proteolysis hsa04120
Cell Process Ubiquitination degradation
Cell apoptosis
Decreased G0/G1 phase
In-vitro Model HET-1A Normal Homo sapiens CVCL_3702
KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
KYSE-450 Esophageal squamous cell carcinoma Homo sapiens CVCL_1353
KYSE-70 Esophageal squamous cell carcinoma Homo sapiens CVCL_1356
TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
In-vivo Model The number of cells inoculated in each mouse was 4 × 106, 1 × 106, 2 × 106 and 1 × 106, respectively.
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary The elevated FTO in esophageal squamous cell carcinoma decreased m6A methylation of LINC00022 transcript, leading to the inhibition of Deleted in lymphocytic leukemia 2 (DLEU2/LINC00022) decay via the m6A reader YTHDF2.
Responsed Disease Esophageal squamous cell carcinoma [ICD-11: 2B70.1]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Cell cycle hsa04110
Ubiquitin mediated proteolysis hsa04120
Cell Process Ubiquitination degradation
Cell apoptosis
Decreased G0/G1 phase
In-vitro Model HET-1A Normal Homo sapiens CVCL_3702
KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
KYSE-450 Esophageal squamous cell carcinoma Homo sapiens CVCL_1353
KYSE-70 Esophageal squamous cell carcinoma Homo sapiens CVCL_1356
TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
In-vivo Model The number of cells inoculated in each mouse was 4 × 106, 1 × 106, 2 × 106 and 1 × 106, respectively.
References
Ref 1 RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma. J Exp Clin Cancer Res. 2021 Sep 20;40(1):294. doi: 10.1186/s13046-021-02096-1.