m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00119)
Target Name microRNA 370 (MIR370)
Synonyms
MIR370; MIRN370; hsa-mir-370
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Gene Name MIR370
Chromosomal Location 14q32.31
Family MicroRNAs
Gene ID 442915
HGNC ID
HGNC:31784
miRBase ID
MI0000778
Ensembl Gene ID
ENSG00000199005
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR370 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Embryonic stem cells Mus musculus
Treatment: METTL3 knockout mESCs
Control: Wild type mESCs
 GSE156481
Regulation
logFC: -4.78E+00
p-value: 3.06E-02
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary In hepatocellular carcinoma, METTL3 could direct the formation of circHPS5, and specific m6A controlled the accumulation of circHPS5. YTHDC1 facilitated the cytoplasmic output of circHPS5 under m6A modification. CircHPS5 can act as a microRNA 370 (MIR370) sponge to regulate the expression of HMGA2 and further accelerate hepatocellular carcinoma cell tumorigenesis.
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Pathway Response Transcriptional misregulation in cancer hsa05202
Cell Process Epithelial-mesenchymal transition
Cell autophagy
In-vitro Model Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
In-vivo Model To create the xenograft neoplasm system, 40 male BALB/c nude mice aged 5 weeks were randomly separated into sh-NC, sh-circHPS5, sh-circHPS5+CTRL, and sh-circHPS5+SAH groups (n = 5 for each group). HCC cells were subcutaneously injected into the axilla of the nude mice.
YTH domain-containing protein 1 (YTHDC1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary In hepatocellular carcinoma, METTL3 could direct the formation of circHPS5, and specific m6A controlled the accumulation of circHPS5. YTHDC1 facilitated the cytoplasmic output of circHPS5 under m6A modification. CircHPS5 can act as a microRNA 370 (MIR370) sponge to regulate the expression of HMGA2 and further accelerate hepatocellular carcinoma cell tumorigenesis.
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Pathway Response Transcriptional misregulation in cancer hsa05202
Cell Process Epithelial-mesenchymal transition
Cell autophagy
In-vitro Model Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
In-vivo Model To create the xenograft neoplasm system, 40 male BALB/c nude mice aged 5 weeks were randomly separated into sh-NC, sh-circHPS5, sh-circHPS5+CTRL, and sh-circHPS5+SAH groups (n = 5 for each group). HCC cells were subcutaneously injected into the axilla of the nude mice.
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary In hepatocellular carcinoma, METTL3 could direct the formation of circHPS5, and specific m6A controlled the accumulation of circHPS5. YTHDC1 facilitated the cytoplasmic output of circHPS5 under m6A modification. CircHPS5 can act as a microRNA 370 (MIR370) sponge to regulate the expression of HMGA2 and further accelerate hepatocellular carcinoma cell tumorigenesis.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Pathway Response Transcriptional misregulation in cancer hsa05202
Cell Process Epithelial-mesenchymal transition
Cell autophagy
In-vitro Model Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
In-vivo Model To create the xenograft neoplasm system, 40 male BALB/c nude mice aged 5 weeks were randomly separated into sh-NC, sh-circHPS5, sh-circHPS5+CTRL, and sh-circHPS5+SAH groups (n = 5 for each group). HCC cells were subcutaneously injected into the axilla of the nude mice.
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary In hepatocellular carcinoma, METTL3 could direct the formation of circHPS5, and specific m6A controlled the accumulation of circHPS5. YTHDC1 facilitated the cytoplasmic output of circHPS5 under m6A modification. CircHPS5 can act as a microRNA 370 (MIR370) sponge to regulate the expression of HMGA2 and further accelerate hepatocellular carcinoma cell tumorigenesis.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Pathway Response Transcriptional misregulation in cancer hsa05202
Cell Process Epithelial-mesenchymal transition
Cell autophagy
In-vitro Model Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
In-vivo Model To create the xenograft neoplasm system, 40 male BALB/c nude mice aged 5 weeks were randomly separated into sh-NC, sh-circHPS5, sh-circHPS5+CTRL, and sh-circHPS5+SAH groups (n = 5 for each group). HCC cells were subcutaneously injected into the axilla of the nude mice.
References
Ref 1 m6A modification of circHPS5 and hepatocellular carcinoma progression through HMGA2 expression. Mol Ther Nucleic Acids. 2021 Sep 14;26:637-648. doi: 10.1016/j.omtn.2021.09.001. eCollection 2021 Dec 3.