m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00097)
Target Name HOXD antisense growth-associated long non-coding RNA (HAGLR)
Synonyms
HAGLR; HOXD-AS1; HOXD cluster antisense RNA 1 (non-protein coding); HOXD cluster antisense RNA 1; Mdgt; MIR7704HG; MIR7704 host gene
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Gene Name HAGLR
Chromosomal Location 2q31.1
Family Long non-coding RNAs with non-systematic symbols
Gene ID 401022
HGNC ID
HGNC:43755
Ensembl Gene ID
ENSG00000224189
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
HAGLR can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary IGF2BP2 loss inhibited cell proliferation, migration and invasion, and induced cell apoptosis and cell cycle arrest by down-regulating HOXD antisense growth-associated long non-coding RNA (HAGLR) expression in an m6A-dependent manner in thyroid cancer cells.
Target Regulation Up regulation
Responsed Disease Thyroid Cancer ICD-11: 2D10
 Disease Info 
Cell Process Cell proliferation
Cell migration
Cell invasion
Cell apoptosis
Cell cycle progression
In-vitro Model TPC-1 Thyroid gland papillary carcinoma Homo sapiens CVCL_6298
Thyroid Cancer [ICD-11: 2D10]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary IGF2BP2 loss inhibited cell proliferation, migration and invasion, and induced cell apoptosis and cell cycle arrest by down-regulating HOXD antisense growth-associated long non-coding RNA (HAGLR) expression in an m6A-dependent manner in thyroid cancer cells.
Responsed Disease Thyroid Cancer [ICD-11: 2D10]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) READER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell proliferation
Cell migration
Cell invasion
Cell apoptosis
Cell cycle progression
In-vitro Model TPC-1 Thyroid gland papillary carcinoma Homo sapiens CVCL_6298
References
Ref 1 IGF2BP2 knockdown suppresses thyroid cancer progression by reducing the expression of long non-coding RNA HAGLR. Pathol Res Pract. 2021 Sep;225:153550. doi: 10.1016/j.prp.2021.153550. Epub 2021 Jul 13.