m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00096)
Target Name FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR)
Synonyms
FENDRR; FOXF1-AS1; FOXF1 antisense RNA 1 (head to head); lincFOXF1; onco-lncRNA-21
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Gene Name FENDRR
Chromosomal Location 16q24.1
Family Long non-coding RNAs with non-systematic symbols
Gene ID 400550
HGNC ID
HGNC:43894
Ensembl Gene ID
ENSG00000268388
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
FENDRR can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between FENDRR and the regulator
Cell Line Hela Homo sapiens
Regulation logFC: 1.55E+00 GSE49339
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary YTHDF2-mediated LncRNA FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR) degradation promotes cell proliferation by elevating SOX4 expression in endometrioid endometrial carcinoma.
Target Regulation Down regulation
Responsed Disease Endometrial cancer ICD-11: 2C76
 Disease Info 
Cell Process Cell proliferation
Cell apoptosis
In-vitro Model HEC-1-B Endometrial adenocarcinoma Homo sapiens CVCL_0294
Endometrial cancer [ICD-11: 2C76]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary YTHDF2-mediated LncRNA FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR) degradation promotes cell proliferation by elevating SOX4 expression in endometrioid endometrial carcinoma.
Responsed Disease Endometrial cancer [ICD-11: 2C76]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
Cell Process Cell proliferation
Cell apoptosis
In-vitro Model HEC-1-B Endometrial adenocarcinoma Homo sapiens CVCL_0294
References
Ref 1 N-methyladenosine reader YTHDF2-mediated long noncoding RNA FENDRR degradation promotes cell proliferation in endometrioid endometrial carcinoma. Lab Invest. 2021 Jun;101(6):775-784. doi: 10.1038/s41374-021-00543-3. Epub 2021 Mar 10.