m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00087)
Target Name Cancer susceptibility 9 (CASC9)
Synonyms
CASC9; cancer susceptibility candidate 9 (non-protein coding); cancer susceptibility 9 (non-protein coding); LINC00981; ESCCAL-1; linc-JPH1; long intergenic non-protein coding RNA 981; esophageal squamous cell carcinoma associated lncRNA-1
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Gene Name CASC9
Chromosomal Location 8q21.13
Family Long non-coding RNAs with non-systematic symbols
Gene ID 101805492
HGNC ID
HGNC:48906
Ensembl Gene ID
ENSG00000249395
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
CASC9 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
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Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Cancer susceptibility 9 (CASC9)/IGF2BP2/HK2 axis promotes the aerobic glycolysis of glioblastoma multiforme.
Target Regulation Up regulation
Responsed Disease Glioblastoma ICD-11: 2A00.00
 Disease Info 
Pathway Response Glycolysis / Gluconeogenesis hsa00010
Cell Process Aerobic glycolysis
In-vitro Model NHA (Normal human astrocytes)
U251 (Fibroblasts or fibroblast like cells)
U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
Brain cancer [ICD-11: 2A00]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Cancer susceptibility 9 (CASC9)/IGF2BP2/HK2 axis promotes the aerobic glycolysis of glioblastoma multiforme.
Responsed Disease Glioblastoma [ICD-11: 2A00.00]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Glycolysis / Gluconeogenesis hsa00010
Cell Process Aerobic glycolysis
In-vitro Model NHA (Normal human astrocytes)
U251 (Fibroblasts or fibroblast like cells)
U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
References
Ref 1 m(6)A reader IGF2BP2-stabilized CASC9 accelerates glioblastoma aerobic glycolysis by enhancing HK2 mRNA stability. Cell Death Discov. 2021 Oct 13;7(1):292. doi: 10.1038/s41420-021-00674-y.