m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00082)
Target Name KCNK15 and WISP2 antisense RNA 1 (KCNK15-AS1)
Synonyms
KCNK15-AS1; KCNK15 antisense RNA 1 (head to head); RP11-445H22.4
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Gene Name KCNK15-AS1
Chromosomal Location 20q13.12
Family Antisense RNAs
Gene ID 106144538
HGNC ID
HGNC:49901
Ensembl Gene ID
ENSG00000244558
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
KCNK15-AS1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
In total 2 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ALKBH5 inhibits pancreatic cancer motility by demethylating lncRNA KCNK15 and WISP2 antisense RNA 1 (KCNK15-AS1).
Target Regulation Up regulation
Responsed Disease Pancreatic cancer ICD-11: 2C10
 Disease Info 
Cell Process Epithelial-mesenchymal transition
Cell migration and invasion
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
HPDE6c7 Normal Homo sapiens CVCL_0P38
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
Experiment 2 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary ALKBH5-mediated m6A demethylation enhanced the stability of KCNK15-AS1. In pancreatic cancer, KCNK15 and WISP2 antisense RNA 1 (KCNK15-AS1) bound to KCNK15 to inhibit its translation, and interacted with MDM2 to induce REST ubiquitination, which eventually facilitated PTEN transcription to inactivate AKT pathway.
Target Regulation Up regulation
Responsed Disease Pancreatic cancer ICD-11: 2C10
 Disease Info 
Cell Process Cell proliferation
Cell migration
Epithelial-mesenchymal transition
Cell apoptosis
In-vitro Model BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
Pancreatic cancer [ICD-11: 2C10]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary ALKBH5 inhibits pancreatic cancer motility by demethylating lncRNA KCNK15 and WISP2 antisense RNA 1 (KCNK15-AS1).
Responsed Disease Pancreatic cancer [ICD-11: 2C10]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Up regulation
Cell Process Epithelial-mesenchymal transition
Cell migration and invasion
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
HPDE6c7 Normal Homo sapiens CVCL_0P38
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
Experiment 2 Reporting the m6A-centered Disease Response [2]
Response Summary ALKBH5-mediated m6A demethylation enhanced the stability of KCNK15-AS1. In pancreatic cancer, KCNK15 and WISP2 antisense RNA 1 (KCNK15-AS1) bound to KCNK15 to inhibit its translation, and interacted with MDM2 to induce REST ubiquitination, which eventually facilitated PTEN transcription to inactivate AKT pathway.
Responsed Disease Pancreatic cancer [ICD-11: 2C10]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell proliferation
Cell migration
Epithelial-mesenchymal transition
Cell apoptosis
In-vitro Model BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
References
Ref 1 ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation. Cell Physiol Biochem. 2018;48(2):838-846. doi: 10.1159/000491915. Epub 2018 Jul 20.
Ref 2 ALKBH5-mediated m(6)A demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN/AKT signaling. Cell Death Dis. 2021 Dec 1;12(12):1121. doi: 10.1038/s41419-021-04401-4.