m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00069)
Target Name hsa_circ_0058493
Synonyms
hsa-circ-0058493
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Gene Name hsa_circ_0058493
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa_circ_0058493 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary In hepatocellular carcinoma, hsa_circ_0058493 contained m6A methylation sites and that METTL3 mediated the degree of methylation modification of hsa_circ_0058493. YTHDC1 could bind to hsa_circ_0058493 and promote its intracellular localization from the nucleus to the cytoplasm.
Target Regulation Up regulation
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Pathway Response Hepatocellular carcinoma hsa05225
Cell Process Cell growth and metastasis
In-vitro Model BEL-7404 Endocervical adenocarcinoma Homo sapiens CVCL_6568
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm Homo sapiens CVCL_0525
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model Groups of HCT116-Luc-shCtrl, HCT116-Luc-shLINC00460, and HCT116-Luc-shLINC00460 + HMGA1 cells (5 × 106) were injected subcutaneously into the flanks of mice correspondingly.
YTH domain-containing protein 1 (YTHDC1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary In hepatocellular carcinoma, hsa_circ_0058493 contained m6A methylation sites and that METTL3 mediated the degree of methylation modification of hsa_circ_0058493. YTHDC1 could bind to hsa_circ_0058493 and promote its intracellular localization from the nucleus to the cytoplasm.
Target Regulation Up regulation
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Pathway Response Hepatocellular carcinoma hsa05225
Cell Process Cell growth and metastasis
In-vitro Model BEL-7404 Endocervical adenocarcinoma Homo sapiens CVCL_6568
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm Homo sapiens CVCL_0525
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model Groups of HCT116-Luc-shCtrl, HCT116-Luc-shLINC00460, and HCT116-Luc-shLINC00460 + HMGA1 cells (5 × 106) were injected subcutaneously into the flanks of mice correspondingly.
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary In hepatocellular carcinoma, hsa_circ_0058493 contained m6A methylation sites and that METTL3 mediated the degree of methylation modification of hsa_circ_0058493. YTHDC1 could bind to hsa_circ_0058493 and promote its intracellular localization from the nucleus to the cytoplasm.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Hepatocellular carcinoma hsa05225
Cell Process Cell growth and metastasis
In-vitro Model BEL-7404 Endocervical adenocarcinoma Homo sapiens CVCL_6568
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm Homo sapiens CVCL_0525
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model Groups of HCT116-Luc-shCtrl, HCT116-Luc-shLINC00460, and HCT116-Luc-shLINC00460 + HMGA1 cells (5 × 106) were injected subcutaneously into the flanks of mice correspondingly.
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary In hepatocellular carcinoma, hsa_circ_0058493 contained m6A methylation sites and that METTL3 mediated the degree of methylation modification of hsa_circ_0058493. YTHDC1 could bind to hsa_circ_0058493 and promote its intracellular localization from the nucleus to the cytoplasm.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Hepatocellular carcinoma hsa05225
Cell Process Cell growth and metastasis
In-vitro Model BEL-7404 Endocervical adenocarcinoma Homo sapiens CVCL_6568
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm Homo sapiens CVCL_0525
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model Groups of HCT116-Luc-shCtrl, HCT116-Luc-shLINC00460, and HCT116-Luc-shLINC00460 + HMGA1 cells (5 × 106) were injected subcutaneously into the flanks of mice correspondingly.
References
Ref 1 Methyltransferase-Like 3-Mediated m6A Methylation of Hsa_circ_0058493 Accelerates Hepatocellular Carcinoma Progression by Binding to YTH Domain-Containing Protein 1. Front Cell Dev Biol. 2021 Nov 23;9:762588. doi: 10.3389/fcell.2021.762588. eCollection 2021.