m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00038)
Target Name Circ_GFR-Alpha-1
Synonyms
Circ-GFR-Alpha-1
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Gene Name Circ_GFR-Alpha-1
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Circ_GFR-Alpha-1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Circ_GFR-Alpha-1 promotes female germline stem cells self-renewal by acting as a ceRNA that sponges miR-449, leading to enhanced GFRalpha-1 expression and activation of the GDNF signaling pathway. circGFRalpha-1 acts as a ceRNA based on METTL14-mediated cytoplasmic export through the GGACU motif.
Responsed Disease Female reproductive system disorders ICD-11: SC4Y
 Disease Info 
Pathway Response Calcium signaling pathway hsa04020
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
FGSCs cell line (Female Germline Stem Cells)
Female reproductive system disorders [ICD-11: SC4Y]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Circ_GFR-Alpha-1 promotes female germline stem cells self-renewal by acting as a ceRNA that sponges miR-449, leading to enhanced GFRalpha-1 expression and activation of the GDNF signaling pathway. circGFRalpha-1 acts as a ceRNA based on METTL14-mediated cytoplasmic export through the GGACU motif.
Responsed Disease Female reproductive system disorders [ICD-11: SC4Y]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Pathway Response Calcium signaling pathway hsa04020
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
FGSCs cell line (Female Germline Stem Cells)
References
Ref 1 Novel circGFRAlpha1 Promotes Self-Renewal of Female Germline Stem Cells Mediated by m(6)A Writer METTL14. Front Cell Dev Biol. 2021 Apr 12;9:640402. doi: 10.3389/fcell.2021.640402. eCollection 2021.