m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00032)
Target Name hsa-miR-183-3p
Synonyms
hsa_miR_183_3p
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Gene Name hsa-miR-183-3p
miRBase ID
MIMAT0004560
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-183-3p can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary rs7495 in 3'UTR of hnRNPC was associated with pancreatic ductal adenocarcinoma susceptibility in a Chinese population. The rs7495, in the hnRNPC 3'UTR, might disrupt a binding site for hsa-miR-183-3p, thus increasing the expression of hnRNPC and promoting the proliferation of PDAC cells.
Target Regulation Down regulation
Responsed Disease Pancreatic ductal adenocarcinoma ICD-11: 2C10.0
 Disease Info 
In-vitro Model BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
Pancreatic cancer [ICD-11: 2C10]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary rs7495 in 3'UTR of hnRNPC was associated with pancreatic ductal adenocarcinoma susceptibility in a Chinese population. The rs7495, in the hnRNPC 3'UTR, might disrupt a binding site for hsa-miR-183-3p, thus increasing the expression of hnRNPC and promoting the proliferation of PDAC cells.
Responsed Disease Pancreatic ductal adenocarcinoma [ICD-11: 2C10.0]
Target Regulator Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) READER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
References
Ref 1 Identification of genetic variants in m(6)A modification genes associated with pancreatic cancer risk in the Chinese population. Arch Toxicol. 2021 Mar;95(3):1117-1128. doi: 10.1007/s00204-021-02978-5. Epub 2021 Jan 21.