m6A Regulator and Potential Drug Response

General Information of the m6A Regulator (ID: REG00026)
Regulator Name Zinc finger CCCH domain-containing protein 13 (ZC3H13)
Synonyms
KIAA0853
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Gene Name ZC3H13
Regulator Type WRITER ERASER READER
Regulator Link Click to View Full Information of This Regulator
Full List of Target Gene(s) of This m6A Regulator and Corresponding Potential Drug Response(s)
Pyruvate kinase M2 (PKM)
CAP-232 [Phase 2a]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Pyruvate kinase M2 (PKM) is a therapeutic target for CAP-232. The Zinc finger CCCH domain-containing protein 13 (ZC3H13) has potential in affecting the response of CAP-232 through regulating the expression of Pyruvate kinase M2 (PKM). [1], [2]
TP-1454 [Phase 1]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Pyruvate kinase M2 (PKM) is a therapeutic target for TP-1454. The Zinc finger CCCH domain-containing protein 13 (ZC3H13) has potential in affecting the response of TP-1454 through regulating the expression of Pyruvate kinase M2 (PKM). [1], [3]
References
Ref 1 ZC3H13 Inhibits the Progression of Hepatocellular Carcinoma through m(6)A-PKM2-Mediated Glycolysis and Enhances Chemosensitivity. J Oncol. 2021 Dec 30;2021:1328444. doi: 10.1155/2021/1328444. eCollection 2021.
Ref 2 TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. doi: 10.1093/nar/30.1.412.
Ref 3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics. 2005 Aug;86(2):127-41. doi: 10.1016/j.ygeno.2005.04.008.