m6A Regulator and Potential Drug Response

General Information of the m6A Regulator (ID: REG00022)
Regulator Name YTH domain-containing protein 1 (YTHDC1)
Synonyms
Splicing factor YT521; YT521-B; KIAA1966; YT521
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Gene Name YTHDC1
Regulator Type WRITER ERASER READER
Regulator Link Click to View Full Information of This Regulator
Full List of Target Gene(s) of This m6A Regulator and Corresponding Potential Drug Response(s)
Helicase-moi messenger RNA (DICER1 mRNA)
ISIS 138612 [Investigative]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Helicase-moi messenger RNA (DICER1 mRNA) is a therapeutic target for ISIS 138612. The YTH domain-containing protein 1 (YTHDC1) has potential in affecting the response of ISIS 138612 through regulating the expression of Helicase-moi messenger RNA (DICER1 mRNA). [1], [2]
ISIS 138613 [Investigative]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Helicase-moi messenger RNA (DICER1 mRNA) is a therapeutic target for ISIS 138613. The YTH domain-containing protein 1 (YTHDC1) has potential in affecting the response of ISIS 138613 through regulating the expression of Helicase-moi messenger RNA (DICER1 mRNA). [1], [2]
ISIS 138616 [Investigative]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Helicase-moi messenger RNA (DICER1 mRNA) is a therapeutic target for ISIS 138616. The YTH domain-containing protein 1 (YTHDC1) has potential in affecting the response of ISIS 138616 through regulating the expression of Helicase-moi messenger RNA (DICER1 mRNA). [1], [2]
ISIS 138647 [Investigative]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Helicase-moi messenger RNA (DICER1 mRNA) is a therapeutic target for ISIS 138647. The YTH domain-containing protein 1 (YTHDC1) has potential in affecting the response of ISIS 138647 through regulating the expression of Helicase-moi messenger RNA (DICER1 mRNA). [1], [2]
ISIS 138648 [Investigative]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Helicase-moi messenger RNA (DICER1 mRNA) is a therapeutic target for ISIS 138648. The YTH domain-containing protein 1 (YTHDC1) has potential in affecting the response of ISIS 138648 through regulating the expression of Helicase-moi messenger RNA (DICER1 mRNA). [1], [2]
ISIS 138649 [Investigative]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Helicase-moi messenger RNA (DICER1 mRNA) is a therapeutic target for ISIS 138649. The YTH domain-containing protein 1 (YTHDC1) has potential in affecting the response of ISIS 138649 through regulating the expression of Helicase-moi messenger RNA (DICER1 mRNA). [1], [2]
ISIS 138678 [Investigative]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Helicase-moi messenger RNA (DICER1 mRNA) is a therapeutic target for ISIS 138678. The YTH domain-containing protein 1 (YTHDC1) has potential in affecting the response of ISIS 138678 through regulating the expression of Helicase-moi messenger RNA (DICER1 mRNA). [1], [3]
Sequestosome-1 p62 (SQSTM1)
IMX-942 [Preclinical]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Sequestosome-1 p62 (SQSTM1) is a therapeutic target for IMX-942. The YTH domain-containing protein 1 (YTHDC1) has potential in affecting the response of IMX-942 through regulating the expression of Sequestosome-1 p62 (SQSTM1). [4], [5]
References
Ref 1 The m(6)A-methylase complex recruits TREX and regulates mRNA export. Sci Rep. 2018 Sep 14;8(1):13827. doi: 10.1038/s41598-018-32310-8.
Ref 2 US patent application no. 7,427,470, Antisense modulation of helicase-moi expression.
Ref 3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 4 m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin. Autophagy. 2022 Jun;18(6):1318-1337. doi: 10.1080/15548627.2021.1974175. Epub 2021 Oct 17.
Ref 5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2393).