General Information of the m6A Regulator (ID: REG00019)
Regulator Name NF-kappa-B-activating protein (NKAP)
Synonyms
FLJ22626, MRXSHD
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Gene Name NKAP
Regulator Type WRITER ERASER READER
Regulator Link Click to View Full Information of This Regulator
Full List of Target Gene(s) of This m6A Regulator and Corresponding Potential Drug Response(s)
Cystine/glutamate transporter (SLC7A11)
L-glutamic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cystine/glutamate transporter (SLC7A11) is a therapeutic target for L-glutamic acid. The NF-kappa-B-activating protein (NKAP) has potential in affecting the response of L-glutamic acid through regulating the expression of Cystine/glutamate transporter (SLC7A11). [1], [2]
SXC-2023 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cystine/glutamate transporter (SLC7A11) is a therapeutic target for SXC-2023. The NF-kappa-B-activating protein (NKAP) has potential in affecting the response of SXC-2023 through regulating the expression of Cystine/glutamate transporter (SLC7A11). [1], [3]
References
Ref 1 RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m(6)A-dependent manner. Cell Death Dis. 2022 Jan 21;13(1):73. doi: 10.1038/s41419-022-04524-2.
Ref 2 The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate. J Biol Chem. 2017 Aug 25;292(34):14240-14249. doi: 10.1074/jbc.M117.798405. Epub 2017 Jun 19.
Ref 3 US patent application no. 6,498,035, Antisense modulation of MEKK3 expression.