m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0078)
Name |
MK22606
|
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Status | Investigative | [1] |
Full List of m6A Targets Related to This Drug
Bone morphogenetic protein 2 (BMP2)
In total 1 item(s) under this target gene | ||||
Experiment 1 Reporting the m6A-centered Drug Response by This Target Gene | [2] | |||
Response Summary | The overexpression of ALKBH5 led to the activation of p-AKT, and Bone morphogenetic protein 2 (BMP2) was regulated by ALKBH5 through the AKT signaling pathway. ALKBH5 promoted the osteogenesis of the ligamentum flavum cells through BMP2 demethylation and AKT activation. MK22606 is an AKT inhibitor. Moreover, when ALKBH5 was knocked down in the ligamentum flavum cells, p-AKT was inhibited when compared with that in the overexpressed ALKBH5 and control groups. | |||
Responsed Disease | Ossification of spinal ligaments | ICD-11: FA83 | ||
Target Regulator | RNA demethylase ALKBH5 (ALKBH5) | ERASER | ||
Target Regulation | Up regulation | |||
Pathway Response | PI3K-Akt signaling pathway | hsa04151 | ||
Cell Process | Ossification | |||
In-vitro Model | Ligamentum flavum cells (Ligamentum flavum cells) | |||
RAC-alpha serine/threonine-protein kinase (AKT1)
In total 1 item(s) under this target gene | ||||
Experiment 1 Reporting the m6A-centered Drug Response by This Target Gene | [2] | |||
Response Summary | The overexpression of ALKBH5 led to the activation of RAC-alpha serine/threonine-protein kinase (AKT1), and BMP2 was regulated by ALKBH5 through the AKT signaling pathway. ALKBH5 promoted the osteogenesis of the ligamentum flavum cells through BMP2 demethylation and AKT activation. MK22606 is an AKT inhibitor. Moreover, when ALKBH5 was knocked down in the ligamentum flavum cells, p-AKT was inhibited when compared with that in the overexpressed ALKBH5 and control groups. | |||
Responsed Disease | Ossification of spinal ligaments | ICD-11: FA83 | ||
Target Regulator | RNA demethylase ALKBH5 (ALKBH5) | ERASER | ||
Target Regulation | Up regulation | |||
Pathway Response | PI3K-Akt signaling pathway | hsa04151 | ||
Cell Process | Ossification | |||
In-vitro Model | Ligamentum flavum cells (Ligamentum flavum cells) | |||
References