m6A-centered Drug Response Information

General Information of the Drug (ID: M6ADRUG0059)
Name
3-Methyladenine
Synonyms
3-Methyl-3H-purin-6-amine; 6-Amino-3-methylpurine; 3-MA; 3-Methyl-3H-adenine; 3H-Purin-6-amine, 3-methyl-; 3-methylpurin-6-amine; NSC 66389; n3-methyladenine; ADENINE, 3-METHYL-; MFCD00010531; CHEBI:38635; UNII-DR88TV7SNU; DR88TV7SNU; 3-METHYL-3H-PURIN-6-YLAMINE; UNII-3899G64TKW; 3899G64TKW; 3-Methyladenine autophagy inhibitor; 60192-57-6; 3-MA nucleobase; 3MA; N(3)-methyladenine; EINECS 225-908-6; BRN 0146087; 3-methyl-7H-purin-6-imine; 3mea; 3-methyl-Adenine; 3-Methyladenine?; NSC66389; 1p7m; 4ai5; 3-Methyladenine (3-MA); Autophagy Inhibitor, 3-MA; NCIOpen2_000270; SCHEMBL48369; 5-26-17-00151 (Beilstein Handbook Reference); MLS006010995; SCHEMBL254058; CHEMBL292268; CHEMBL4303725; SCHEMBL15764619; 3-Methyl-3H-purin-6-amine #; AOB2548; DTXSID80199406; EX-A130; Bio1_000422; Bio1_000911; Bio1_001400; HMS3656P04; ZINC403086; 3-Methyl-7H-purine-6(3H)-imine; ACN-C001131; AMY11868; BCP02452; 3-Methyladenine, autophagy inhibitor; BDBM50488841; NSC-66389; QC-518; s2767; AKOS003382321; AKOS006228458; ZINC100003619; ACN-001131; CCG-206388; CS-5207; DB04104; MCULE-5086156902; NSC 66389 (3-MA); NCGC00345447-02; 3,9-dihydro-3-methyl-6H-Purin-6-imine; AC-28818; AS-19224; HY-19312; Purine, 3,6-dihydro-6-imino-3-methyl-; SMR002530641; SY026559; DB-051961; 6H-Purin-6-imine, 3,7-dihydro-3-methyl-; 6H-Purin-6-imine, 3,9-dihydro-3-methyl-; A7582; FT-0635560; FT-0671432; M2518; SW220216-1; X5709; 3-methyl-3H-purin-6-amine (ACD/Name 4.0); C00913; 3-methyl-3H-purin-6-ylamine (ACD/Name 4.0); J-640198; J-800199; W-202935; BRD-K81647657-001-01-9; Q27094948
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Status Investigative [1]
Structure
Formula
C6H7N5
InChI
InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3,7H,1H3,(H,8,9)
InChIKey
ZPBYVFQJHWLTFB-UHFFFAOYSA-N
PubChem CID
135398661
Full List of m6A Targets Related to This Drug
Autophagy protein 5 (ATG5)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Drug Response by This Target Gene [2]
Response Summary m6A methyltransferase METTL3 regulates autophagy and sensitivity to cisplatin by targeting Autophagy protein 5 (ATG5) in seminoma. The use of autophagy inhibitors 3-MA could reverse the protective effect of METTL3 on TCam-2 cells.
Responsed Disease Testicular cancer ICD-11: 2C80
 Disease Info 
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Autophagy hsa04140
Cell Process Cellular Processes
Cellular Transport
Cellular catabolism
Cell autophagy
In-vitro Model Tcam-2/DDP (Cisplatin-resistant TCam-2 cell line)
TCam-2 Testicular seminoma Homo sapiens CVCL_T012
References
Ref 1 Inhibition of autophagy by 3-MA promotes hypoxia-induced apoptosis in human colorectal cancer cells. Eur Rev Med Pharmacol Sci. 2019 Feb;23(3):1047-1054. doi: 10.26355/eurrev_201902_16992.
Ref 2 The m6A methyltransferase METTL3 regulates autophagy and sensitivity to cisplatin by targeting ATG5 in seminoma. Transl Androl Urol. 2021 Apr;10(4):1711-1722. doi: 10.21037/tau-20-1411.