m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0180)
| Name |
Injury of blood vessels of thorax
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|---|---|---|---|---|---|
| ICD |
ICD-11: NB30
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Full List of Target Gene(s) of This m6A-centered Disease Response
Extracellular sulfatase Sulf-2 (Sulf2)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | METTL16 regulates Extracellular sulfatase Sulf-2 (Sulf2) expression via m6A modification and thereby contribute to PM2.5-induced pulmonary microvascular injury. | |||
| Responsed Disease | Injury of pulmonary blood vessels [ICD-11: NB30.4] | |||
| Target Regulator | Methyltransferase-like 16 (METTL16) | WRITER | ||
| Target Regulation | Down regulation | |||
| In-vitro Model | Rattus norvegicus (Rat pulmonary microvascular endothelial cells (PMVECs) were isolated from lung tissues) | |||
| In-vivo Model | The rats were randomly divided into a fresh air group and a COPD group and each group contained 10 rats. The COPD group was placed into a breathable cage and exposed to PM2.5 (1.46 mg/m3) from the motor vehicle exhaust for two 2-h exposure periods (from 9:00 a.m. to 11:00 a.m. and from 15:00 p.m. to 17:00 p.m.), 5 days per week, for 7 months. After each period of exposure, the animals were exposed to fresh air for 30 min to take a rest. Gasoline-powered motorcycle used as of source of the Particulate matter (PM) pollution was located next door to the rat exposure room, and the PM was directed towards the exposure room through a metal tube. Fresh air was sent to through an air pump. After exposed for 7 months, rats were performed lung function test using a Forced Pulmonary Maneuver System (Buxco Research Systems, Wilmington, NC, USA). | |||