m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0089)
Name
Alzheimer disease
ICD
ICD-11: 8A20
Full List of Target Gene(s) of This m6A-centered Disease Response
Nucleolar protein 3 (ARC)
 Target Info 
In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary METTL3 rescues the A-Bete-induced reduction of Nucleolar protein 3 (ARC) expression via YTHDF1-Dependent m6A modification, which suggests an important mechanism of epigenetic alteration in AD.
Responsed Disease Alzheimer disease [ICD-11: 8A20]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary METTL3 rescues the A-Bete-induced reduction of Nucleolar protein 3 (ARC) expression via YTHDF1-Dependent m6A modification, which suggests an important mechanism of epigenetic alteration in AD.
Responsed Disease Alzheimer disease [ICD-11: 8A20]
Target Regulator YTH domain-containing family protein 1 (YTHDF1) READER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
References
Ref 1 Methyltransferase-Like 3 Rescues the Amyloid-beta protein-Induced Reduction of Activity-Regulated Cytoskeleton Associated Protein Expression via YTHDF1-Dependent N6-Methyladenosine Modification. Front Aging Neurosci. 2022 Apr 25;14:890134. doi: 10.3389/fnagi.2022.890134. eCollection 2022.