m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0064)
Name |
Merkel cell carcinoma
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ICD |
ICD-11: 2C34
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Full List of Target Gene(s) of This m6A-centered Disease Response
Eukaryotic translation initiation factor 3 subunit A (EIF3A/EIF3)
In total 1 item(s) under this target gene | ||||
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
Response Summary | knockdown of YTHDF1 in Merkel cell carcinoma (MCC) cell lines negatively affected the translation initiation factor Eukaryotic translation initiation factor 3 subunit A (EIF3A/EIF3) and reduced proliferation and clonogenic capacity in vitro. | |||
Responsed Disease | Merkel cell carcinoma [ICD-11: 2C34] | |||
Target Regulator | YTH domain-containing family protein 1 (YTHDF1) | READER | ||
Target Regulation | Up regulation | |||
Pathway Response | mRNA surveillance pathway | hsa03015 | ||
Cell Process | Translation | |||
In-vitro Model | MCC13 | Merkel cell carcinoma | Homo sapiens | CVCL_2583 |
MCC26 | Merkel cell carcinoma | Homo sapiens | CVCL_2585 | |
MKL-1 | Merkel cell carcinoma | Homo sapiens | CVCL_2600 | |
MKL-2 | Merkel cell carcinoma | Homo sapiens | CVCL_D027 | |
PeTa | Merkel cell carcinoma | Homo sapiens | CVCL_LC73 | |
UISO-MCC-1 | Merkel cell carcinoma | Homo sapiens | CVCL_E996 | |
WaGa | Merkel cell carcinoma | Homo sapiens | CVCL_E998 | |