m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0024)
Name
Chronic pain
ICD
ICD-11: MG30
Full List of Target Gene(s) of This m6A-centered Disease Response
Methylcytosine dioxygenase TET1 (TET1)
 Target Info 
In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Downregulated spinal cord METTL3 coordinating with YTHDF2 contributes to the modulation of inflammatory pain through stabilizing upregulation of Methylcytosine dioxygenase TET1 (TET1) in spinal neurons.
Responsed Disease Chronic pain [ICD-11: MG30]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Downregulated spinal cord METTL3 coordinating with YTHDF2 contributes to the modulation of inflammatory pain through stabilizing upregulation of Methylcytosine dioxygenase TET1 (TET1) in spinal neurons.
Responsed Disease Chronic pain [ICD-11: MG30]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
mmu-miR-365-3p
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [2]
Response Summary METTL3 positively modulated the mmu-miR-365-3p processing in a microprocessor protein DiGeorge critical region 8-dependent manner.METTL3-mediated m6A modification in nociceptive sensitization and provide a novel perspective on m6A modification in the development of Inflammatory pain.
Responsed Disease Chronic pain [ICD-11: MG30]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response MicroRNAs in cancer hsa05206
Cell Process RNA stability
References
Ref 1 Methyltransferase-like 3 contributes to inflammatory pain by targeting TET1 in YTHDF2-dependent manner. Pain. 2021 Jul 1;162(7):1960-1976. doi: 10.1097/j.pain.0000000000002218.
Ref 2 METTL3 regulates inflammatory pain by modulating m(6)A-dependent pri-miR-365-3p processing. FASEB J. 2020 Jan;34(1):122-132. doi: 10.1096/fj.201901555R. Epub 2019 Nov 19.