m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01730)

Target Name	Dual specificity protein phosphatase 9 (DUSP9)
Synonyms	EC 3.1.3.16; EC 3.1.3.48; Mitogen-activated protein kinase phosphatase 4; MAP kinase phosphatase 4; MKP-4 Click to Show/Hide
Gene Name	DUSP9
Chromosomal Location	Xq28
Family	Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Function	Inactivates MAP kinases. Has a specificity for the ERK family. Click to Show/Hide
Gene ID	1852
Uniprot ID	DUS9_HUMAN
HGNC ID	HGNC:3076
KEGG ID	hsa:1852

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: Zinc finger CCCH domain-containing protein 13 (ZC3H13)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05165		Crosstalk Info
Epigenetic Regulator	hsa-miR-200c-3p
Regulated Target	Zinc finger CCCH domain-containing protein 13 (ZC3H13)
Crosstalk relationship	ncRNA → m6A
Disease	Brain cancer	Disease Info
Drug	Levetiracetam	Drug Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01730)

Dual specificity protein phosphatase 9 (DUSP9)

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004613		Click to Show/Hide the Full List
mod site	chrX:153651016-153651017:+		[2]
Sequence	ACTTTTGCTGCTGCGGGGCCCACACAGCCGCTGCTACTTTG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000342782.4; ENST00000370167.8
External Link	RMBase: m5C_site_45567

N6-methyladenosine (m6A)

In total 25 m6A sequence/site(s) in this target gene
mod ID: M6ASITE093802		Click to Show/Hide the Full List
mod site	chrX:153642559-153642560:+		[3]
Sequence	CCGCCGCCCGAGCTTCGGAAACTTCCCGGCCGCGACGCAGG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000370167.8; ENST00000477033.1
External Link	RMBase: m6A_site_876711
mod ID: M6ASITE093803		Click to Show/Hide the Full List
mod site	chrX:153642582-153642583:+		[3]
Sequence	TCCCGGCCGCGACGCAGGGAACCGGCGCGGAGAACCGAGCA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000370167.8; ENST00000477033.1
External Link	RMBase: m6A_site_876712
mod ID: M6ASITE093804		Click to Show/Hide the Full List
mod site	chrX:153642595-153642596:+		[3]
Sequence	GCAGGGAACCGGCGCGGAGAACCGAGCAGAGCGGAGGTGAG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000477033.1; ENST00000370167.8
External Link	RMBase: m6A_site_876713
mod ID: M6ASITE093805		Click to Show/Hide the Full List
mod site	chrX:153647329-153647330:+		[4]
Sequence	CCTGGCGGCCAGGCCTGGGGACTCTCTGCCGCGGGACGGCG
Motif Score	4.065041667
Cell/Tissue List	HepG2; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000370167.8; ENST00000342782.4; ENST00000477033.1
External Link	RMBase: m6A_site_876714
mod ID: M6ASITE093806		Click to Show/Hide the Full List
mod site	chrX:153647470-153647471:+		[4]
Sequence	GGGGTAGGGGGAGATGGGGGACCGGGGGCCAGACCACCTCT
Motif Score	3.622404762
Cell/Tissue List	HepG2; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000342782.4; ENST00000370167.8; ENST00000477033.1
External Link	RMBase: m6A_site_876715
mod ID: M6ASITE093807		Click to Show/Hide the Full List
mod site	chrX:153647482-153647483:+		[4]
Sequence	GATGGGGGACCGGGGGCCAGACCACCTCTGAGAGGACTCGC
Motif Score	2.876744048
Cell/Tissue List	HepG2; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000342782.4; ENST00000477033.1; ENST00000370167.8
External Link	RMBase: m6A_site_876716
mod ID: M6ASITE093808		Click to Show/Hide the Full List
mod site	chrX:153647497-153647498:+		[4]
Sequence	GCCAGACCACCTCTGAGAGGACTCGCTGAGGCCCAGCACCT
Motif Score	4.065041667
Cell/Tissue List	HepG2; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000342782.4; ENST00000370167.8; ENST00000477033.1
External Link	RMBase: m6A_site_876717
mod ID: M6ASITE093809		Click to Show/Hide the Full List
mod site	chrX:153647620-153647621:+		[5]
Sequence	AGCCAGAGTCGGAAGCTCGAACTTGGGGAGCGTTCGCGAGA
Motif Score	3.373380952
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000370167.8; ENST00000342782.4; ENST00000477033.1
External Link	RMBase: m6A_site_876718
mod ID: M6ASITE093810		Click to Show/Hide the Full List
mod site	chrX:153647643-153647644:+		[5]
Sequence	TGGGGAGCGTTCGCGAGAAGACCGAGACAGGAGCAGAAAGG
Motif Score	2.876744048
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000477033.1; ENST00000370167.8; ENST00000342782.4
External Link	RMBase: m6A_site_876719
mod ID: M6ASITE093811		Click to Show/Hide the Full List
mod site	chrX:153647649-153647650:+		[5]
Sequence	GCGTTCGCGAGAAGACCGAGACAGGAGCAGAAAGGGGGTAT
Motif Score	2.897386905
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000477033.1; ENST00000370167.8; ENST00000342782.4
External Link	RMBase: m6A_site_876720
mod ID: M6ASITE093812		Click to Show/Hide the Full List
mod site	chrX:153648029-153648030:+		[4]
Sequence	GCCGCGGCTCCTGCTCCTGGACTGCCGCAGCCGCGAGCTGT
Motif Score	4.065041667
Cell/Tissue List	HepG2; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000370167.8; ENST00000342782.4
External Link	RMBase: m6A_site_876721
mod ID: M6ASITE093813		Click to Show/Hide the Full List
mod site	chrX:153649275-153649276:+		[5]
Sequence	AGTGCCCTCACCTGTGTGAGACCAGCCTTGCTGGCCGTGCC
Motif Score	2.876744048
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000342782.4; ENST00000370167.8
External Link	RMBase: m6A_site_876722
mod ID: M6ASITE093814		Click to Show/Hide the Full List
mod site	chrX:153649538-153649539:+		[5]
Sequence	AATTTGGAGAGCCTGGCCAAACTGGGCATCCGCTACATCCT
Motif Score	2.627720238
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000370167.8; ENST00000342782.4
External Link	RMBase: m6A_site_876723
mod ID: M6ASITE093815		Click to Show/Hide the Full List
mod site	chrX:153649552-153649553:+		[6]
Sequence	GGCCAAACTGGGCATCCGCTACATCCTCAATGTCACCCCCA
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000370167.8; ENST00000342782.4
External Link	RMBase: m6A_site_876724
mod ID: M6ASITE093816		Click to Show/Hide the Full List
mod site	chrX:153649582-153649583:+		[5]
Sequence	TGTCACCCCCAACCTCCCAAACTTCTTCGAGAAGAATGGTG
Motif Score	2.627720238
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000370167.8; ENST00000342782.4
External Link	RMBase: m6A_site_876725
mod ID: M6ASITE093817		Click to Show/Hide the Full List
mod site	chrX:153649612-153649613:+		[6]
Sequence	GAAGAATGGTGACTTTCACTACAAGCAGATCCCCATCTCCG
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000370167.8; ENST00000342782.4
External Link	RMBase: m6A_site_876726
mod ID: M6ASITE093818		Click to Show/Hide the Full List
mod site	chrX:153649648-153649649:+		[5]
Sequence	CTCCGACCACTGGAGCCAGAACCTGTCGCGGTTCTTTCCGG
Motif Score	2.930744048
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000370167.8; ENST00000342782.4
External Link	RMBase: m6A_site_876727
mod ID: M6ASITE093819		Click to Show/Hide the Full List
mod site	chrX:153649997-153649998:+		[5]
Sequence	AGATGAGGCCTTGTCCCAGAACTGCGGGGTGCTCGTCCACT
Motif Score	3.373380952
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000342782.4; ENST00000370167.8
External Link	RMBase: m6A_site_876728
mod ID: M6ASITE093820		Click to Show/Hide the Full List
mod site	chrX:153650165-153650166:+		[3]
Sequence	CTTCATGGGGCAGTTGCTGGACTTTGAGCGCAGCTTGCGGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000342782.4; ENST00000370167.8
External Link	RMBase: m6A_site_876729
mod ID: M6ASITE093821		Click to Show/Hide the Full List
mod site	chrX:153650475-153650476:+		[3]
Sequence	ATCAACGTGCCTATGGCGGGACCACGCTCGGAGCCTGCCTC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000342782.4; ENST00000370167.8
External Link	RMBase: m6A_site_876730
mod ID: M6ASITE093822		Click to Show/Hide the Full List
mod site	chrX:153650509-153650510:+		[7]
Sequence	CTGCCTCTTCTGCGACTGTTACTTTTTCTTTGCGGGATGGG
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000370167.8; ENST00000342782.4
External Link	RMBase: m6A_site_876731
mod ID: M6ASITE093823		Click to Show/Hide the Full List
mod site	chrX:153650774-153650775:+		[3]
Sequence	GGGCCTCCCAGGGGATGGGGACCCAGAGTGCAGTGGCCGCC
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000370167.8; ENST00000342782.4
External Link	RMBase: m6A_site_876732
mod ID: M6ASITE093824		Click to Show/Hide the Full List
mod site	chrX:153650929-153650930:+		[3]
Sequence	TTGTGAGTGAGGGTGGCCAAACTACCGCCGGAGGAGATGGG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; U2OS
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000370167.8; ENST00000342782.4
External Link	RMBase: m6A_site_876733
mod ID: M6ASITE093825		Click to Show/Hide the Full List
mod site	chrX:153651064-153651065:+		[3]
Sequence	GGGAAGGGGCCAAGCTGCAGACACACACAGTCATTCATTTC
Motif Score	2.897386905
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000342782.4; ENST00000370167.8
External Link	RMBase: m6A_site_876734
mod ID: M6ASITE093826		Click to Show/Hide the Full List
mod site	chrX:153651305-153651306:+		[3]
Sequence	TAATTGTTCCTTCTGAATAAACAGTTTATTTAAGATACTGA
Motif Score	2.20572619
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000342782.4; ENST00000370167.8
External Link	RMBase: m6A_site_876735

Ref 1	Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154. doi: 10.1155/2011/483154. Epub 2010 Dec 27.
Ref 2	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 5	[Action myoclonias and paranoid alternative psychosis in progressive myoclonic epilepsy (late form of the Lafora type)]. Nervenarzt. 1986 Apr;57(4):233-7.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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