m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01695)
Target Name Transcription factor E2F6 (E2F6)
Synonyms
E2F-6
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Gene Name E2F6
Chromosomal Location 2p25.1
Family E2F/DP family
Function
Inhibitor of E2F-dependent transcription (PubMed:9689056, PubMed:9704927, PubMed:9501179). Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:9501179). Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9501179). E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9704927, PubMed:9501179). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (PubMed:9689056, PubMed:9501179). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (PubMed:9501179).
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Gene ID 1876
Uniprot ID
E2F6_HUMAN
HGNC ID
HGNC:3120
KEGG ID
hsa:1876
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05066
 Crosstalk Info 
Epigenetic Regulator Read-through Circular RNA E2F
Regulated Target Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Crosstalk relationship ncRNA → m6A
Disease Liver cancer
 Disease Info 
m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05068
 Crosstalk Info 
Epigenetic Regulator Read-through Circular RNA E2F
Regulated Target Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Crosstalk relationship ncRNA → m6A
Disease Liver cancer
 Disease Info 
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01695)
Transcription factor E2F6 (E2F6)
N6-methyladenosine (m6A)
In total 23 m6A sequence/site(s) in this target gene
mod ID: M6ASITE043093 Click to Show/Hide the Full List
mod site chr2:11444554-11444555:- [2]
Sequence GAGAAGGCAGTGTCCCAAAAACCAACAAAGGTTTTACCAAA
Motif Score 2.185083333
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000444832.5; ENST00000546212.2; ENST00000307236.8; ENST00000542100.5; ENST00000428221.5; ENST00000381525.8
External Link RMBase: m6A_site_461242
mod ID: M6ASITE043094 Click to Show/Hide the Full List
mod site chr2:11445357-11445358:- [3]
Sequence ACTTTGTCATAATCACTGTTACATCCCAGTGCCTCACACCA
Motif Score 2.07285119
Cell/Tissue List kidney
Seq Type List m6A-REF-seq
Transcript ID List ENST00000307236.8; ENST00000542100.5; ENST00000381525.8; ENST00000444832.5; rmsk_463746; ENST00000428221.5; ENST00000546212.2; ENST00000455198.5
External Link RMBase: m6A_site_461243
mod ID: M6ASITE043095 Click to Show/Hide the Full List
mod site chr2:11445732-11445733:- [4]
Sequence TTCTTGGTTTTAAGCTGTCTACCTAATTGCTGTCTCCCAGC
Motif Score 2.05802381
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000542100.5; ENST00000428221.5; ENST00000455198.5; ENST00000381525.8; ENST00000307236.8; ENST00000444832.5; ENST00000546212.2
External Link RMBase: m6A_site_461244
mod ID: M6ASITE043096 Click to Show/Hide the Full List
mod site chr2:11445932-11445933:- [5]
Sequence GTATATATGGAAAGTGACAGACAAATTCTCTAATCTCTTTG
Motif Score 2.897386905
Cell/Tissue List HeLa; HEK293T; Huh7
Seq Type List m6A-seq; DART-seq; MeRIP-seq
Transcript ID List ENST00000307236.8; ENST00000444832.5; ENST00000381525.8; ENST00000455198.5; ENST00000428221.5; ENST00000542100.5; ENST00000546212.2
External Link RMBase: m6A_site_461245
mod ID: M6ASITE043097 Click to Show/Hide the Full List
mod site chr2:11445936-11445937:- [4]
Sequence TAATGTATATATGGAAAGTGACAGACAAATTCTCTAATCTC
Motif Score 2.859755952
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000428221.5; ENST00000455198.5; ENST00000307236.8; ENST00000542100.5; ENST00000444832.5; ENST00000381525.8; ENST00000546212.2
External Link RMBase: m6A_site_461246
mod ID: M6ASITE043098 Click to Show/Hide the Full List
mod site chr2:11446001-11446002:- [4]
Sequence GTATAATGTTGAGATTACTTACGAAATATGTCTGAGTGACA
Motif Score 2.046785714
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000542100.5; ENST00000307236.8; ENST00000428221.5; ENST00000444832.5; ENST00000546212.2; ENST00000455198.5; ENST00000381525.8
External Link RMBase: m6A_site_461247
mod ID: M6ASITE043099 Click to Show/Hide the Full List
mod site chr2:11446005-11446006:- [4]
Sequence ATCTGTATAATGTTGAGATTACTTACGAAATATGTCTGAGT
Motif Score 2.494845238
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000542100.5; ENST00000381525.8; ENST00000307236.8; ENST00000546212.2; ENST00000428221.5; ENST00000455198.5; ENST00000444832.5
External Link RMBase: m6A_site_461248
mod ID: M6ASITE043100 Click to Show/Hide the Full List
mod site chr2:11446120-11446121:- [4]
Sequence CAAGGAGTATGTCATATATCACAAAAGAAATTGCCTTACAC
Motif Score 2.047297619
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000455198.5; ENST00000428221.5; ENST00000444832.5; ENST00000307236.8; ENST00000381525.8; ENST00000542100.5; ENST00000546212.2
External Link RMBase: m6A_site_461249
mod ID: M6ASITE043101 Click to Show/Hide the Full List
mod site chr2:11446156-11446157:- [5]
Sequence AAATGGACAGTTCTTTGTGGACTCTACCCTTCCCTTCAAGG
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000542100.5; ENST00000428221.5; ENST00000546212.2; ENST00000444832.5; ENST00000307236.8; ENST00000381525.8; ENST00000455198.5
External Link RMBase: m6A_site_461250
mod ID: M6ASITE043102 Click to Show/Hide the Full List
mod site chr2:11446170-11446171:- [5]
Sequence AGACAGTCAGGCTGAAATGGACAGTTCTTTGTGGACTCTAC
Motif Score 3.643047619
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq; m6A-REF-seq
Transcript ID List ENST00000542100.5; ENST00000381525.8; ENST00000546212.2; ENST00000307236.8; ENST00000428221.5; ENST00000455198.5; ENST00000444832.5
External Link RMBase: m6A_site_461251
mod ID: M6ASITE043103 Click to Show/Hide the Full List
mod site chr2:11446188-11446189:- [4]
Sequence ACAGAGTGTCATGAAGACAGACAGTCAGGCTGAAATGGACA
Motif Score 2.897386905
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000546212.2; ENST00000542100.5; ENST00000307236.8; ENST00000444832.5; ENST00000381525.8; ENST00000455198.5; ENST00000428221.5
External Link RMBase: m6A_site_461252
mod ID: M6ASITE043104 Click to Show/Hide the Full List
mod site chr2:11446192-11446193:- [5]
Sequence CATCACAGAGTGTCATGAAGACAGACAGTCAGGCTGAAATG
Motif Score 2.897386905
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000542100.5; ENST00000455198.5; ENST00000428221.5; ENST00000381525.8; ENST00000444832.5; ENST00000307236.8; ENST00000546212.2
External Link RMBase: m6A_site_461253
mod ID: M6ASITE043105 Click to Show/Hide the Full List
mod site chr2:11446236-11446237:- [5]
Sequence GCTTTTTGTCAGTGAAATAGACATCTTGCCTCCTGAAGTAG
Motif Score 2.897386905
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1B; hNPCs; hESCs; fibroblasts; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq; m6A-REF-seq
Transcript ID List ENST00000542100.5; ENST00000455198.5; ENST00000381525.8; ENST00000546212.2; ENST00000471343.5; ENST00000307236.8; ENST00000444832.5; ENST00000428221.5
External Link RMBase: m6A_site_461254
mod ID: M6ASITE043106 Click to Show/Hide the Full List
mod site chr2:11446281-11446282:- [5]
Sequence TGTGGTTTCCACATTTGAAAACAACTCCTTTTATAATTATT
Motif Score 2.20572619
Cell/Tissue List HeLa; HEK293T; hNPCs; A549; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000455198.5; ENST00000428221.5; ENST00000381525.8; ENST00000471343.5; ENST00000444832.5; ENST00000307236.8; ENST00000542100.5; ENST00000546212.2
External Link RMBase: m6A_site_461255
mod ID: M6ASITE043107 Click to Show/Hide the Full List
mod site chr2:11447691-11447692:- [4]
Sequence GGAGCAGGGTCAGACCAGTAACAAAAGGTCTGAAGGTGTCG
Motif Score 2.168095238
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000455198.5; ENST00000307236.8; ENST00000542100.5; ENST00000437573.5; ENST00000546212.2; ENST00000428221.5; ENST00000471343.5; ENST00000381525.8; ENST00000444832.5
External Link RMBase: m6A_site_461256
mod ID: M6ASITE043108 Click to Show/Hide the Full List
mod site chr2:11450074-11450075:- [5]
Sequence AGCATTCAGGCCTTCCATGAACAGATCGTCATTGCAGTTAA
Motif Score 2.951386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000444832.5; ENST00000437573.5; ENST00000471343.5; ENST00000428221.5; ENST00000421117.1; ENST00000307236.8; ENST00000546212.2; ENST00000542100.5; ENST00000455198.5; ENST00000381525.8
External Link RMBase: m6A_site_461257
mod ID: M6ASITE043109 Click to Show/Hide the Full List
mod site chr2:11450102-11450103:- [5]
Sequence AGCATATGTGACCTATCAAGACATTCATAGCATTCAGGCCT
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000455198.5; ENST00000444832.5; ENST00000428221.5; ENST00000307236.8; ENST00000421117.1; ENST00000381525.8; ENST00000437573.5; ENST00000542100.5; ENST00000546212.2; ENST00000471343.5
External Link RMBase: m6A_site_461258
mod ID: M6ASITE043110 Click to Show/Hide the Full List
mod site chr2:11451228-11451229:- [5]
Sequence CCTCAGGGGTACAGTACCAAACCAAGGTTGATGGTACCACT
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000381525.8; ENST00000307236.8; ENST00000471343.5; ENST00000546212.2; ENST00000444832.5; ENST00000421117.1; ENST00000455198.5; ENST00000542100.5; ENST00000437573.5; ENST00000428221.5
External Link RMBase: m6A_site_461259
mod ID: M6ASITE043111 Click to Show/Hide the Full List
mod site chr2:11453747-11453748:- [4]
Sequence ATGTATCGCTGGTTTATTTAACTCGAAAATTTATGGATCTT
Motif Score 2.590089286
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000542100.5; ENST00000444832.5; ENST00000307236.8; ENST00000381525.8; ENST00000455198.5; ENST00000421117.1; ENST00000546212.2; ENST00000437573.5; ENST00000428221.5; ENST00000468775.1
External Link RMBase: m6A_site_461260
mod ID: M6ASITE043112 Click to Show/Hide the Full List
mod site chr2:11465796-11465797:- [5]
Sequence GGTTCGCCGTCGGTGCCGAGACCCCATCAACGTGGAGGGCC
Motif Score 2.876744048
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000444832.5; ENST00000455198.5; ENST00000542100.5; ENST00000421117.1; ENST00000307236.8; ENST00000468775.1; ENST00000546212.2; ENST00000437573.5; ENST00000498701.1; ENST00000428221.5; ENST00000381525.8
External Link RMBase: m6A_site_461261
mod ID: M6ASITE043113 Click to Show/Hide the Full List
mod site chr2:11465832-11465833:- [5]
Sequence GTTACCCAGTCTCCTCCTGGACCCGACGGAGGAGACGGTTC
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000498701.1; ENST00000444832.5; ENST00000437573.5; ENST00000468775.1; ENST00000307236.8; ENST00000381525.8; ENST00000546212.2; ENST00000428221.5; ENST00000542100.5; ENST00000455198.5; ENST00000421117.1
External Link RMBase: m6A_site_461262
mod ID: M6ASITE043114 Click to Show/Hide the Full List
mod site chr2:11465995-11465996:- [5]
Sequence CGCCTCGGAGGAAGCCGCGGACCCCTTAGGTGCTGGGCCCT
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; GSC-11
Seq Type List m6A-seq
Transcript ID List ENST00000428221.5; ENST00000437573.5; ENST00000546212.2; ENST00000307236.8; ENST00000421117.1; ENST00000381525.8; ENST00000542100.5; ENST00000444832.5; ENST00000468775.1; ENST00000498701.1
External Link RMBase: m6A_site_461263
mod ID: M6ASITE043115 Click to Show/Hide the Full List
mod site chr2:11466032-11466033:- [4]
Sequence CGCGTTTACTGGCGGGCGGGACGGCCTAGCCGGGCGGCGCC
Motif Score 3.616982143
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000444832.5; ENST00000381525.8; ENST00000428221.5; ENST00000437573.5; ENST00000421117.1; ENST00000542100.5; ENST00000498701.1; ENST00000307236.8; ENST00000546212.2; ENST00000468775.1
External Link RMBase: m6A_site_461264