m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01636)

Target Name	Chromobox protein homolog 1 (CBX1)
Synonyms	HP1Hsbeta; Heterochromatin protein 1 homolog beta; HP1 beta; Heterochromatin protein p25; M31; Modifier 1 protein; p25beta Click to Show/Hide
Gene Name	CBX1
Chromosomal Location	17q21.32
Function	Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Click to Show/Hide
Gene ID	10951
Uniprot ID	CBX1_HUMAN
HGNC ID	HGNC:1551
KEGG ID	hsa:10951

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Histone modification

m6A Regulator: YTH domain-containing family protein 3 (YTHDF3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03186		Crosstalk Info
Epigenetic Regulator	Chromobox protein homolog 1 (CBX1)
Regulated Target	Histone H3 lysine 9 trimethylation (H3K9me3)
Crosstalk relationship	m6A → Histone modification
Disease	Nasopharyngeal carcinoma	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01636)

Chromobox protein homolog 1 (CBX1)

N4-acetylcytidine (ac4C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000227		Click to Show/Hide the Full List
mod site	chr17:48100788-48100789:-		[2]
Sequence	GGACTACGGAGGAGTAACGTCGAGTGAATTGGAAGAGGGCC
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000393408.7; ENST00000495350.5; ENST00000581003.5; ENST00000402583.5; ENST00000225603.9
External Link	RMBase: ac4C_site_815

Adenosine-to-Inosine editing (A-to-I)

In total 3 m6A sequence/site(s) in this target gene
mod ID: A2ISITE008223		Click to Show/Hide the Full List
mod site	chr17:48073249-48073250:-		[3]
Sequence	GCTCTGATTTCCTGTTATTAAGGTTCTAGAGATTTGGGGTG
Transcript ID List	ENST00000393408.7; ENST00000581003.5; ENST00000225603.9; ENST00000402583.5
External Link	RMBase: RNA-editing_site_58778
mod ID: A2ISITE008224		Click to Show/Hide the Full List
mod site	chr17:48093143-48093144:-		[3]
Sequence	GTAGTTGGGTAGCTGGGATTACAGGCGCCTGCCATCATGCC
Transcript ID List	ENST00000581003.5; ENST00000225603.9; ENST00000495350.5; ENST00000444685.1; ENST00000393408.7; ENST00000402583.5
External Link	RMBase: RNA-editing_site_58779
mod ID: A2ISITE008225		Click to Show/Hide the Full List
mod site	chr17:48099003-48099004:-		[3]
Sequence	GGTCTTCTGCATTTCTGAATACAGGATACCTATAACTTACA
Transcript ID List	ENST00000393408.7; ENST00000402583.5; ENST00000225603.9; ENST00000444685.1; ENST00000581003.5; ENST00000495350.5
External Link	RMBase: RNA-editing_site_58780

2'-O-Methylation (2'-O-Me)

In total 3 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000162		Click to Show/Hide the Full List
mod site	chr17:48088731-48088732:-		[4]
Sequence	GGAACGATACAGAGAAGATTAGCATGGCCCCTATGCAAAGA
Cell/Tissue List	N.A.; HEK293
Seq Type List	RiboMeth-seq
Transcript ID List	ENST00000581003.5; ENST00000384227.1; ENST00000225603.9; ENST00000393408.7; rmsk_4708515; ENST00000495350.5; ENST00000444685.1; ENST00000402583.5
External Link	RMBase: Nm_site_2502
mod ID: 2OMSITE000163		Click to Show/Hide the Full List
mod site	chr17:48088737-48088738:-		[4]
Sequence	AAAATTGGAACGATACAGAGAAGATTAGCATGGCCCCTATG
Cell/Tissue List	N.A.; HEK293
Seq Type List	RiboMeth-seq
Transcript ID List	ENST00000495350.5; ENST00000402583.5; ENST00000384227.1; ENST00000225603.9; rmsk_4708515; ENST00000444685.1; ENST00000393408.7; ENST00000581003.5
External Link	RMBase: Nm_site_2503
mod ID: 2OMSITE000161		Click to Show/Hide the Full List
mod site	chr17:48088730-48088731:-		[4]
Sequence	GAACGATACAGAGAAGATTAGCATGGCCCCTATGCAAAGAC
Seq Type List	RiboMeth-seq
Transcript ID List	ENST00000225603.9; rmsk_4708515; ENST00000384227.1; ENST00000581003.5; ENST00000393408.7; ENST00000444685.1; ENST00000495350.5; ENST00000402583.5
External Link	RMBase: Nm_site_2501

N1-methyladenosine (m1A)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M1ASITE000058		Click to Show/Hide the Full List
mod site	chr17:48071185-48071186:-		[5]
Sequence	CTTTTCTGCACTTTGCTGCGAAAAGCAAAGGGCCTTCTATG
Cell/Tissue List	HEK293T
Seq Type List	m1A-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m1A_site_462

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001205		Click to Show/Hide the Full List
mod site	chr17:48101472-48101473:-		[6]
Sequence	TTGCGCCTGCGCGGTGCGAGCGGCGGGCAGCGCAGACTGCG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000225603.9
External Link	RMBase: m5C_site_19398

N6-methyladenosine (m6A)

In total 54 m6A sequence/site(s) in this target gene
mod ID: M6ASITE033537		Click to Show/Hide the Full List
mod site	chr17:48070098-48070099:-		[7]
Sequence	TTAAATGTAAACTTCATACTACATTGTCAGTTTTTGTCTTA
Motif Score	2.078666667
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369183
mod ID: M6ASITE033538		Click to Show/Hide the Full List
mod site	chr17:48070101-48070102:-		[7]
Sequence	TGTTTAAATGTAAACTTCATACTACATTGTCAGTTTTTGTC
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369184
mod ID: M6ASITE033539		Click to Show/Hide the Full List
mod site	chr17:48070125-48070126:-		[8]
Sequence	TGTGTTAGATTTCTGTGTAAACTTTGTTTAAATGTAAACTT
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369185
mod ID: M6ASITE033540		Click to Show/Hide the Full List
mod site	chr17:48070168-48070169:-		[7]
Sequence	CTAGACTTGCATCTAGAGCTACGTTGTAAAATTCTTTTAGG
Motif Score	2.05260119
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369186
mod ID: M6ASITE033541		Click to Show/Hide the Full List
mod site	chr17:48070184-48070185:-		[8]
Sequence	CAGTTCTTGATATTGTCTAGACTTGCATCTAGAGCTACGTT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369187
mod ID: M6ASITE033542		Click to Show/Hide the Full List
mod site	chr17:48070209-48070210:-		[8]
Sequence	CTCTGTCTTGAGTCATGAGAACCATCAGTTCTTGATATTGT
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369188
mod ID: M6ASITE033543		Click to Show/Hide the Full List
mod site	chr17:48070239-48070240:-		[7]
Sequence	GAAATCCTAATAAGTAACATACCCAAAATGCTCTGTCTTGA
Motif Score	2.089839286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369189
mod ID: M6ASITE033544		Click to Show/Hide the Full List
mod site	chr17:48070243-48070244:-		[7]
Sequence	TTAAGAAATCCTAATAAGTAACATACCCAAAATGCTCTGTC
Motif Score	2.168095238
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369190
mod ID: M6ASITE033545		Click to Show/Hide the Full List
mod site	chr17:48070271-48070272:-		[8]
Sequence	CACACACATACACACACAAAACAATTTTTTAAGAAATCCTA
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369191
mod ID: M6ASITE033546		Click to Show/Hide the Full List
mod site	chr17:48070292-48070293:-		[8]
Sequence	GGGCAGTGGTTCACTTTAAAACACACACATACACACACAAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369192
mod ID: M6ASITE033547		Click to Show/Hide the Full List
mod site	chr17:48070323-48070324:-		[8]
Sequence	TGGTCTCAGGAGAAGATTAAACTTTCATATTGGGCAGTGGT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369193
mod ID: M6ASITE033548		Click to Show/Hide the Full List
mod site	chr17:48070381-48070382:-		[7]
Sequence	TCACTGACAGCACAAGTTTCACTGAATTGATCCAAGAGTTT
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369194
mod ID: M6ASITE033549		Click to Show/Hide the Full List
mod site	chr17:48070390-48070391:-		[9]
Sequence	AGGGTTCAGTCACTGACAGCACAAGTTTCACTGAATTGATC
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369195
mod ID: M6ASITE033550		Click to Show/Hide the Full List
mod site	chr17:48070430-48070431:-		[9]
Sequence	CCGTTTACTTTGAGCTTTGAACACTGAAACCATTGTTGGCA
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369196
mod ID: M6ASITE033551		Click to Show/Hide the Full List
mod site	chr17:48070488-48070489:-		[9]
Sequence	AGGTAAGACAGTAGGGAAAGACAAGGGCCCATGCTCTTAGT
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369197
mod ID: M6ASITE033552		Click to Show/Hide the Full List
mod site	chr17:48070501-48070502:-		[7]
Sequence	AGGGTGGTAGAGGAGGTAAGACAGTAGGGAAAGACAAGGGC
Motif Score	2.897386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369198
mod ID: M6ASITE033553		Click to Show/Hide the Full List
mod site	chr17:48070601-48070602:-		[8]
Sequence	CTAATTCCCGAAATTAGAAGACCCTTTCTTTTCCAGTAACG
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369199
mod ID: M6ASITE033554		Click to Show/Hide the Full List
mod site	chr17:48070649-48070650:-		[9]
Sequence	TTTATTGGAGAGTATACAGTACAAGCAGATCATTCTGCCTT
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369200
mod ID: M6ASITE033555		Click to Show/Hide the Full List
mod site	chr17:48070686-48070687:-		[7]
Sequence	CATTTTGGAGATGGAAATTGACGAGGAGGGAAGGTCTTTTA
Motif Score	2.833690476
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369201
mod ID: M6ASITE033556		Click to Show/Hide the Full List
mod site	chr17:48070737-48070738:-		[8]
Sequence	TATTGCTGTTCCCACAAAGGACTAAGCCTGTTCATAAGTTA
Motif Score	4.065041667
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369202
mod ID: M6ASITE033557		Click to Show/Hide the Full List
mod site	chr17:48070744-48070745:-		[9]
Sequence	CTAAACTTATTGCTGTTCCCACAAAGGACTAAGCCTGTTCA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369203
mod ID: M6ASITE033558		Click to Show/Hide the Full List
mod site	chr17:48070760-48070761:-		[8]
Sequence	CCAAGGTGTTCCCTGCCTAAACTTATTGCTGTTCCCACAAA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369204
mod ID: M6ASITE033559		Click to Show/Hide the Full List
mod site	chr17:48070789-48070790:-		[8]
Sequence	AAAAGCTGTGAAAGTCTGAAACCTATAAGCCAAGGTGTTCC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; hNPCs; hESCs; fibroblasts; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369205
mod ID: M6ASITE033560		Click to Show/Hide the Full List
mod site	chr17:48070816-48070817:-		[8]
Sequence	ATAAATAAGGACTGTGAGAGACTGTTTAAAAGCTGTGAAAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; hNPCs; hESCs; fibroblasts; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369206
mod ID: M6ASITE033561		Click to Show/Hide the Full List
mod site	chr17:48070826-48070827:-		[8]
Sequence	CATTGGCACCATAAATAAGGACTGTGAGAGACTGTTTAAAA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; hNPCs; hESCs; fibroblasts; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369207
mod ID: M6ASITE033562		Click to Show/Hide the Full List
mod site	chr17:48070898-48070899:-		[9]
Sequence	GAAGCAATGGAAAAGAACAGACAACTAATGATTTGCTTCTA
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369208
mod ID: M6ASITE033563		Click to Show/Hide the Full List
mod site	chr17:48070902-48070903:-		[8]
Sequence	TGGTGAAGCAATGGAAAAGAACAGACAACTAATGATTTGCT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; hNPCs; hESCs; fibroblasts; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369209
mod ID: M6ASITE033564		Click to Show/Hide the Full List
mod site	chr17:48070946-48070947:-		[7]
Sequence	GGGTAGCATCATTTTGATTAACATTTGGGGCCTGATAGGGG
Motif Score	2.168095238
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369210
mod ID: M6ASITE033565		Click to Show/Hide the Full List
mod site	chr17:48071017-48071018:-		[7]
Sequence	GTGTGTAGTTTTTGGCTATTACTGGTGTATTATTTGGGGGA
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369211
mod ID: M6ASITE033566		Click to Show/Hide the Full List
mod site	chr17:48071049-48071050:-		[7]
Sequence	AGTGTTAACTCTGCATTTTTACAGCGTAGCATGTGTGTAGT
Motif Score	2.07285119
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369212
mod ID: M6ASITE033567		Click to Show/Hide the Full List
mod site	chr17:48071062-48071063:-		[7]
Sequence	CCTTCTTCCCAATAGTGTTAACTCTGCATTTTTACAGCGTA
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369213
mod ID: M6ASITE033568		Click to Show/Hide the Full List
mod site	chr17:48071093-48071094:-		[9]
Sequence	GATCTTCAAAGAGCATCTCCACAACCCACAGCCTTCTTCCC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369214
mod ID: M6ASITE033569		Click to Show/Hide the Full List
mod site	chr17:48071119-48071120:-		[7]
Sequence	GTGTGGGAGAGCAAAAAAATACTGTAGATCTTCAAAGAGCA
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369215
mod ID: M6ASITE033570		Click to Show/Hide the Full List
mod site	chr17:48071160-48071161:-		[9]
Sequence	CAAAGGGCCTTCTATGAAGGACAAAACTTGCAGAATTGGGT
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369216
mod ID: M6ASITE033571		Click to Show/Hide the Full List
mod site	chr17:48071252-48071253:-		[9]
Sequence	TTTCAAGCTGTATAGTTTGCACACCCATCCCAGTGGAGGGG
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369217
mod ID: M6ASITE033572		Click to Show/Hide the Full List
mod site	chr17:48071358-48071359:-		[9]
Sequence	AAGGAGTTCTACTTGTCTTGACACCATAGAGGTGGCTTGAG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369219
mod ID: M6ASITE033573		Click to Show/Hide the Full List
mod site	chr17:48071409-48071410:-		[9]
Sequence	CCTGAGTACCAGCCCCTGTCACATCTGACTGTGGGTTTCAA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m6A_site_369220
mod ID: M6ASITE033574		Click to Show/Hide the Full List
mod site	chr17:48071438-48071439:-		[10]
Sequence	TGACAAAAAAGATGACAAGAACTAACGCTCCTGAGTACCAG
Motif Score	3.373380952
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369221
mod ID: M6ASITE033575		Click to Show/Hide the Full List
mod site	chr17:48071456-48071457:-		[9]
Sequence	CTACCCCTCGGAGGATGATGACAAAAAAGATGACAAGAACT
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369222
mod ID: M6ASITE033576		Click to Show/Hide the Full List
mod site	chr17:48071487-48071488:-		[7]
Sequence	CCTTCTATGAGGAAAGGCTGACGTGGCATTCCTACCCCTCG
Motif Score	2.833690476
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000393408.7; ENST00000581003.5; ENST00000225603.9
External Link	RMBase: m6A_site_369223
mod ID: M6ASITE033577		Click to Show/Hide the Full List
mod site	chr17:48075038-48075039:-		[11]
Sequence	GCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGT
Motif Score	3.319380952
Cell/Tissue List	hNPCs; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000402583.5; ENST00000581003.5; ENST00000495350.5; ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m6A_site_369224
mod ID: M6ASITE033578		Click to Show/Hide the Full List
mod site	chr17:48076021-48076022:-		[11]
Sequence	GATAAGGGAGAGGAGAGCAAACCAAAGAAGAAGAAAGAAGA
Motif Score	2.185083333
Cell/Tissue List	hNPCs; fibroblasts; LCLs; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000581003.5; ENST00000402583.5; ENST00000225603.9; ENST00000444685.1; ENST00000393408.7; ENST00000495350.5
External Link	RMBase: m6A_site_369225
mod ID: M6ASITE033579		Click to Show/Hide the Full List
mod site	chr17:48076089-48076090:-		[12]
Sequence	CACAGAAAACAGCACATGAGACAGATAAATCAGAGGGAGGC
Motif Score	2.897386905
Cell/Tissue List	CD34; HepG2; hNPCs; fibroblasts; LCLs; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000581003.5; ENST00000402583.5; ENST00000393408.7; ENST00000495350.5; ENST00000225603.9; ENST00000444685.1
External Link	RMBase: m6A_site_369226
mod ID: M6ASITE033580		Click to Show/Hide the Full List
mod site	chr17:48076101-48076102:-		[12]
Sequence	AGTTTCTGCAGTCACAGAAAACAGCACATGAGACAGATAAA
Motif Score	2.20572619
Cell/Tissue List	CD34; HepG2; hNPCs; fibroblasts; LCLs; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000393408.7; ENST00000495350.5; ENST00000402583.5; ENST00000225603.9; ENST00000581003.5; ENST00000444685.1
External Link	RMBase: m6A_site_369227
mod ID: M6ASITE033581		Click to Show/Hide the Full List
mod site	chr17:48076148-48076149:-		[12]
Sequence	CACATGGGAGCCAGAAGAGAACCTGGATTGCCCCGACCTCA
Motif Score	2.930744048
Cell/Tissue List	CD34; HepG2; hNPCs; fibroblasts; LCLs; MM6; Huh7; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000393408.7; ENST00000444685.1; ENST00000495350.5; ENST00000581003.5; ENST00000225603.9; ENST00000402583.5
External Link	RMBase: m6A_site_369228
mod ID: M6ASITE033582		Click to Show/Hide the Full List
mod site	chr17:48076172-48076173:-		[12]
Sequence	GCCCTCTGGTTTCAGTGAGGACAACACATGGGAGCCAGAAG
Motif Score	3.643047619
Cell/Tissue List	CD34; HepG2; hESC-HEK293T; hNPCs; fibroblasts; LCLs; MM6; Huh7; NB4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000581003.5; ENST00000444685.1; ENST00000225603.9; ENST00000402583.5; ENST00000495350.5; ENST00000393408.7
External Link	RMBase: m6A_site_369229
mod ID: M6ASITE033583		Click to Show/Hide the Full List
mod site	chr17:48076987-48076988:-		[12]
Sequence	CACTATGGGGAAAAAACAAAACAAGAAGAAAGTGGAGGAGG
Motif Score	2.20572619
Cell/Tissue List	CD34; HepG2; hESC-HEK293T; hNPCs; fibroblasts; MM6; Huh7; NB4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000444685.1; ENST00000225603.9; ENST00000402583.5; ENST00000581003.5; ENST00000495350.5; ENST00000393408.7
External Link	RMBase: m6A_site_369230
mod ID: M6ASITE033584		Click to Show/Hide the Full List
mod site	chr17:48076992-48076993:-		[12]
Sequence	GCGGGCACTATGGGGAAAAAACAAAACAAGAAGAAAGTGGA
Motif Score	2.20572619
Cell/Tissue List	CD34; HepG2; hNPCs; HEK293T; fibroblasts; MM6; Huh7; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000444685.1; ENST00000402583.5; ENST00000225603.9; ENST00000581003.5; ENST00000495350.5; ENST00000393408.7
External Link	RMBase: m6A_site_369231
mod ID: M6ASITE033585		Click to Show/Hide the Full List
mod site	chr17:48100821-48100822:-		[8]
Sequence	CGGCTGGGACTGCCAGAGGAACCTGGCTTTGCAGGACTACG
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9; ENST00000402583.5; ENST00000495350.5; ENST00000581003.5
External Link	RMBase: m6A_site_369232
mod ID: M6ASITE033586		Click to Show/Hide the Full List
mod site	chr17:48100833-48100834:-		[8]
Sequence	AGACGCCGGGTCCGGCTGGGACTGCCAGAGGAACCTGGCTT
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000402583.5; ENST00000495350.5; ENST00000225603.9; ENST00000581003.5; ENST00000393408.7
External Link	RMBase: m6A_site_369233
mod ID: M6ASITE033587		Click to Show/Hide the Full List
mod site	chr17:48100927-48100928:-		[8]
Sequence	GCGGGATAGGGCGGAAGGGGACAGGCTTGAGGCTTGGATAG
Motif Score	3.643047619
Cell/Tissue List	HeLa; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9; ENST00000495350.5; ENST00000581003.5; ENST00000402583.5
External Link	RMBase: m6A_site_369234
mod ID: M6ASITE033588		Click to Show/Hide the Full List
mod site	chr17:48100971-48100972:-		[8]
Sequence	CGGGGCCCGGGTGGTCTGGAACAATGTTGCTTGGCTGGGCG
Motif Score	2.951386905
Cell/Tissue List	HeLa; H1B; GSC-11; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7; ENST00000581003.5; ENST00000495350.5; ENST00000402583.5
External Link	RMBase: m6A_site_369235
mod ID: M6ASITE033589		Click to Show/Hide the Full List
mod site	chr17:48101034-48101035:-		[8]
Sequence	GCGCGAATCCTGAGCCAGAGACTGAGTGCTTGGGGGTGGGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; H1B; GSC-11
Seq Type List	m6A-seq
Transcript ID List	ENST00000581003.5; ENST00000495350.5; ENST00000225603.9; ENST00000402583.5; ENST00000393408.7
External Link	RMBase: m6A_site_369236
mod ID: M6ASITE033590		Click to Show/Hide the Full List
mod site	chr17:48101457-48101458:-		[8]
Sequence	GCGAGCGGCGGGCAGCGCAGACTGCGAGGCTCTTTTGTTCG
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000225603.9
External Link	RMBase: m6A_site_369237

N7-methylguanosine (m7G)

In total 2 m6A sequence/site(s) in this target gene
mod ID: m7GSITE000044		Click to Show/Hide the Full List
mod site	chr17:48070991-48070992:-		[13]
Sequence	GTATTATTTGGGGGAGGGAGGGATGGGGAGGGGAGAAAGGG
Cell/Tissue List	A549; HeLa; HepG2
Seq Type List	BoRed-seq&m7G-RIP-seq; m7G-seq
Transcript ID List	ENST00000225603.9; ENST00000393408.7
External Link	RMBase: m7G_site_379
mod ID: m7GSITE000046		Click to Show/Hide the Full List
mod site	chr17:48071113-48071114:-		[13]
Sequence	GAGAGCAAAAAAATACTGTAGATCTTCAAAGAGCATCTCCA
Cell/Tissue List	A549; HeLa; HepG2
Seq Type List	BoRed-seq&m7G-RIP-seq; m7G-seq
Transcript ID List	ENST00000393408.7; ENST00000225603.9
External Link	RMBase: m7G_site_380

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000098		Click to Show/Hide the Full List
mod site	chr17:48088744-48088745:-		[14]
Sequence	ATGTACTAAAATTGGAACGATACAGAGAAGATTAGCATGGC
Transcript ID List	ENST00000581003.5; ENST00000225603.9; ENST00000402583.5; ENST00000384227.1; ENST00000444685.1; ENST00000393408.7; ENST00000495350.5; rmsk_4708515
External Link	RMBase: Pseudo_site_2210

Ref 1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 2	NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Res. 2023 Sep 8;51(16):8514-8531. doi: 10.1093/nar/gkad628.
Ref 3	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 4	Substoichiometric ribose methylations in spliceosomal snRNAs. Org Biomol Chem. 2017 Oct 31;15(42):8872-8876. doi: 10.1039/c7ob02317k.
Ref 5	The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Nature. 2017 Nov 9;551(7679):251-255. doi: 10.1038/nature24456. Epub 2017 Oct 25.
Ref 6	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 7	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 8	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 9	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 10	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 11	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 12	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 13	METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25.
Ref 14	snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D158-62. doi: 10.1093/nar/gkj002.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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