m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01456)

Target Name	Protein arginine N-methyltransferase 6 (PRMT6)
Synonyms	EC 2.1.1.319; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6 Click to Show/Hide
Gene Name	PRMT6
Chromosomal Location	1p13.3
Family	Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family, PRMT6 subfamily
Function	Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869). Methylates HMGA1 (PubMed:16157300, PubMed:16159886). Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity). May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505). Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity). Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (PubMed:30420520). Click to Show/Hide
Gene ID	55170
Uniprot ID	ANM6_HUMAN
HGNC ID	HGNC:18241
KEGG ID	hsa:55170

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05290		Crosstalk Info
Epigenetic Regulator	hsa-miR-34a-5p
Regulated Target	Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Crosstalk relationship	ncRNA → m6A
Disease	Acute myeloid leukaemia	Disease Info
Crosstalk ID: M6ACROT05292		Crosstalk Info
Epigenetic Regulator	GNAS antisense RNA 1 (GNAS-AS1)
Regulated Target	hsa-miR-34a-5p
Crosstalk relationship	ncRNA → m6A
Disease	Acute myeloid leukaemia	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01456)

Protein arginine N-methyltransferase 6 (PRMT6)

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002787		Click to Show/Hide the Full List
mod site	chr1:107056707-107056708:+		[4]
Sequence	CCGCCGGGAGCCGGGCAGAGCGGCCAAGATGTCGCAGCCCA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000370078.1
External Link	RMBase: m5C_site_2951
mod ID: M5CSITE002788		Click to Show/Hide the Full List
mod site	chr1:107058062-107058063:+		[4]
Sequence	ATCCCCCTCAACAACGGATACAGCGTGCTTATTATTGGGCA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000370078.1; ENST00000650338.1; ENST00000649727.1
External Link	RMBase: m5C_site_2952

N6-methyladenosine (m6A)

In total 50 m6A sequence/site(s) in this target gene
mod ID: M6ASITE040459		Click to Show/Hide the Full List
mod site	chr1:107056775-107056776:+		[5]
Sequence	GCGGCGAAGGAGGGGAGGGAACTGAAGAGGAAGATGGCGCG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MT4; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000370078.1
External Link	RMBase: m6A_site_42794
mod ID: M6ASITE040460		Click to Show/Hide the Full List
mod site	chr1:107056829-107056830:+		[5]
Sequence	CCCTGGAGCGACCCCGGAGGACTAAGCGGGAACGGGACCAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000370078.1
External Link	RMBase: m6A_site_42795
mod ID: M6ASITE040461		Click to Show/Hide the Full List
mod site	chr1:107056845-107056846:+		[5]
Sequence	GAGGACTAAGCGGGAACGGGACCAGCTGTACTACGAGTGCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000370078.1
External Link	RMBase: m6A_site_42796
mod ID: M6ASITE040462		Click to Show/Hide the Full List
mod site	chr1:107056902-107056903:+		[5]
Sequence	CCACGAGGAGATGATCGCGGACCGCGTCCGCACCGATGCCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m6A_site_42797
mod ID: M6ASITE040463		Click to Show/Hide the Full List
mod site	chr1:107056944-107056945:+		[5]
Sequence	CCGCCTGGGTATCCTTCGGAACTGGGCAGCACTGCGAGGCA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hESCs; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m6A_site_42798
mod ID: M6ASITE040464		Click to Show/Hide the Full List
mod site	chr1:107057106-107057107:+		[5]
Sequence	GCGGTTCAACGGGCTGGAGGACCGGGTGCACGTCCTGCCGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000370078.1; ENST00000650338.1
External Link	RMBase: m6A_site_42799
mod ID: M6ASITE040465		Click to Show/Hide the Full List
mod site	chr1:107057128-107057129:+		[5]
Sequence	CGGGTGCACGTCCTGCCGGGACCAGTGGAGACTGTAGAGTT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000370078.1; ENST00000650338.1
External Link	RMBase: m6A_site_42800
mod ID: M6ASITE040466		Click to Show/Hide the Full List
mod site	chr1:107057138-107057139:+		[5]
Sequence	TCCTGCCGGGACCAGTGGAGACTGTAGAGTTGCCGGAACAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m6A_site_42801
mod ID: M6ASITE040467		Click to Show/Hide the Full List
mod site	chr1:107057155-107057156:+		[5]
Sequence	GAGACTGTAGAGTTGCCGGAACAGGTGGATGCCATCGTGAG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; hESC-HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; DART-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m6A_site_42802
mod ID: M6ASITE040468		Click to Show/Hide the Full List
mod site	chr1:107057194-107057195:+		[5]
Sequence	AGCGAGTGGATGGGCTACGGACTCCTGCACGAGTCCATGCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hESCs; GM12878; LCLs; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000370078.1; ENST00000650338.1
External Link	RMBase: m6A_site_42803
mod ID: M6ASITE040469		Click to Show/Hide the Full List
mod site	chr1:107057202-107057203:+		[6]
Sequence	GATGGGCTACGGACTCCTGCACGAGTCCATGCTGAGCTCCG
Motif Score	2.80452381
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m6A_site_42804
mod ID: M6ASITE040470		Click to Show/Hide the Full List
mod site	chr1:107057237-107057238:+		[5]
Sequence	GCTCCGTCCTCCACGCGCGAACCAAGTGGCTGAAGGAGGGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000370078.1; ENST00000650338.1
External Link	RMBase: m6A_site_42805
mod ID: M6ASITE040471		Click to Show/Hide the Full List
mod site	chr1:107057367-107057368:+		[5]
Sequence	GAAGCAGCACTATGGTGTGGACATGAGCTGCCTGGAGGGCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m6A_site_42806
mod ID: M6ASITE040474		Click to Show/Hide the Full List
mod site	chr1:107057623-107057624:+		[5]
Sequence	CCTGGAGGGGAGTCGGAGAAACCCCTGGTGCTGTCCACCTC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; fibroblasts; GM12878; MM6; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000370078.1; ENST00000649727.1; ENST00000650338.1
External Link	RMBase: m6A_site_42807
mod ID: M6ASITE040485		Click to Show/Hide the Full List
mod site	chr1:107057671-107057672:+		[5]
Sequence	CACCCGGCCACTCACTGGAAACAGGCGCTCCTCTACCTGAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000650338.1; ENST00000370078.1; ENST00000649727.1
External Link	RMBase: m6A_site_42808
mod ID: M6ASITE040488		Click to Show/Hide the Full List
mod site	chr1:107057715-107057716:+		[5]
Sequence	GCCGGTGCAAGTGGAGCAAGACACGGACGTTTCAGGAGAGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000649727.1; ENST00000370078.1; ENST00000650338.1
External Link	RMBase: m6A_site_42809
mod ID: M6ASITE040489		Click to Show/Hide the Full List
mod site	chr1:107057757-107057758:+		[5]
Sequence	CACGCTGCTGCCCTCCCGGGACAACCCCCGTCGCCTGCGCG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; hESC-HEK293T; BGC823; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000650338.1; ENST00000649727.1; ENST00000370078.1
External Link	RMBase: m6A_site_42810
mod ID: M6ASITE040490		Click to Show/Hide the Full List
mod site	chr1:107057802-107057803:+		[5]
Sequence	GCTGCGCTACAAAGTGGGAGACCAGGAGGAGAAGACCAAAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; BGC823; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000370078.1; ENST00000650338.1; ENST00000649727.1
External Link	RMBase: m6A_site_42811
mod ID: M6ASITE040491		Click to Show/Hide the Full List
mod site	chr1:107057816-107057817:+		[5]
Sequence	TGGGAGACCAGGAGGAGAAGACCAAAGACTTTGCCATGGAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; BGC823; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000649727.1; ENST00000370078.1; ENST00000650338.1
External Link	RMBase: m6A_site_42812
mod ID: M6ASITE040492		Click to Show/Hide the Full List
mod site	chr1:107057823-107057824:+		[5]
Sequence	CCAGGAGGAGAAGACCAAAGACTTTGCCATGGAGGACTGAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; BGC823; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000370078.1; ENST00000650338.1; ENST00000649727.1
External Link	RMBase: m6A_site_42813
mod ID: M6ASITE040493		Click to Show/Hide the Full List
mod site	chr1:107057838-107057839:+		[5]
Sequence	CAAAGACTTTGCCATGGAGGACTGAGCGTTGCCTTTTCTCC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; BGC823; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000649727.1; ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m6A_site_42814
mod ID: M6ASITE040494		Click to Show/Hide the Full List
mod site	chr1:107057882-107057883:+		[6]
Sequence	CTACCTCCCAAAGCAGCCTGACCTGCGTGGGAGAGGCGTAG
Motif Score	2.839113095
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000650338.1; ENST00000370078.1; ENST00000649727.1
External Link	RMBase: m6A_site_42815
mod ID: M6ASITE040495		Click to Show/Hide the Full List
mod site	chr1:107058030-107058031:+		[6]
Sequence	AGATTCTTCTGGTGATGTTTACTTAAAAAGTGATCCCCCTC
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000370078.1; ENST00000650338.1; ENST00000649727.1
External Link	RMBase: m6A_site_42816
mod ID: M6ASITE040496		Click to Show/Hide the Full List
mod site	chr1:107058159-107058160:+		[7]
Sequence	CGGGGGAGTGAGGGGGAAGAACACGGATGAAAATGTCAGTT
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T; Huh7
Seq Type List	MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000649727.1; ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m6A_site_42817
mod ID: M6ASITE040497		Click to Show/Hide the Full List
mod site	chr1:107058196-107058197:+		[6]
Sequence	AGTTTTTGAAGGGTCCATGCACATCCCTGACACCTCACACC
Motif Score	2.830589286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000370078.1; ENST00000649727.1; ENST00000650338.1
External Link	RMBase: m6A_site_42818
mod ID: M6ASITE040498		Click to Show/Hide the Full List
mod site	chr1:107058205-107058206:+		[6]
Sequence	AGGGTCCATGCACATCCCTGACACCTCACACCTTATCTAAG
Motif Score	2.859755952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000649727.1; ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m6A_site_42819
mod ID: M6ASITE040499		Click to Show/Hide the Full List
mod site	chr1:107058212-107058213:+		[7]
Sequence	ATGCACATCCCTGACACCTCACACCTTATCTAAGTCTGAAG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000650338.1; ENST00000649727.1; ENST00000370078.1
External Link	RMBase: m6A_site_42820
mod ID: M6ASITE040500		Click to Show/Hide the Full List
mod site	chr1:107058257-107058258:+		[8]
Sequence	GGAGAAAGGGGTTCATTTAGACTTCATACATTTCCAGTACG
Motif Score	3.319380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000650338.1; ENST00000649727.1; ENST00000370078.1
External Link	RMBase: m6A_site_42821
mod ID: M6ASITE040501		Click to Show/Hide the Full List
mod site	chr1:107058264-107058265:+		[7]
Sequence	GGGGTTCATTTAGACTTCATACATTTCCAGTACGACTTTAG
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000649727.1; ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m6A_site_42822
mod ID: M6ASITE040502		Click to Show/Hide the Full List
mod site	chr1:107058381-107058382:+		[6]
Sequence	CCTCATTGTTTTCTAGGTAAACTTCACTACTGGTAATTAAG
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000649727.1; ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m6A_site_42823
mod ID: M6ASITE040503		Click to Show/Hide the Full List
mod site	chr1:107058445-107058446:+		[6]
Sequence	TAAATAGCCCTGTTCTCATTACTCTGACCACATACATCATA
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000370078.1; ENST00000649727.1; ENST00000650338.1
External Link	RMBase: m6A_site_42824
mod ID: M6ASITE040504		Click to Show/Hide the Full List
mod site	chr1:107058454-107058455:+		[7]
Sequence	CTGTTCTCATTACTCTGACCACATACATCATAGGGTGCTAA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000370078.1; ENST00000649727.1; ENST00000650338.1
External Link	RMBase: m6A_site_42825
mod ID: M6ASITE040505		Click to Show/Hide the Full List
mod site	chr1:107058523-107058524:+		[6]
Sequence	AAAATGGACTTTGTAATTGTACAGCATACCTAAGAAACTCA
Motif Score	2.856142857
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000370078.1; ENST00000649727.1; ENST00000650338.1
External Link	RMBase: m6A_site_42826
mod ID: M6ASITE040506		Click to Show/Hide the Full List
mod site	chr1:107058539-107058540:+		[6]
Sequence	TTGTACAGCATACCTAAGAAACTCAGAAGGTGCATTTAAGA
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000650338.1; ENST00000649727.1; ENST00000370078.1
External Link	RMBase: m6A_site_42827
mod ID: M6ASITE040507		Click to Show/Hide the Full List
mod site	chr1:107058607-107058608:+		[6]
Sequence	TTTTAAAAATTCTTGTCTCTACTATTATAACCAAAAAATAT
Motif Score	2.500660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000370078.1; ENST00000650338.1; ENST00000649727.1
External Link	RMBase: m6A_site_42828
mod ID: M6ASITE040508		Click to Show/Hide the Full List
mod site	chr1:107058739-107058740:+		[6]
Sequence	ACCATGGGTAAATTATTTAAACTCACTTAATTAAGGAAAAT
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000370078.1; ENST00000650338.1; ENST00000649727.1
External Link	RMBase: m6A_site_42829
mod ID: M6ASITE040509		Click to Show/Hide the Full List
mod site	chr1:107058743-107058744:+		[6]
Sequence	TGGGTAAATTATTTAAACTCACTTAATTAAGGAAAATATTT
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000650338.1; ENST00000649727.1; ENST00000370078.1
External Link	RMBase: m6A_site_42830
mod ID: M6ASITE040510		Click to Show/Hide the Full List
mod site	chr1:107058837-107058838:+		[7]
Sequence	TCATGTGAGTTGGCCTACTTACAAGTAGTGAAAGTTCCCTT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000650338.1; ENST00000649727.1; ENST00000370078.1
External Link	RMBase: m6A_site_42831
mod ID: M6ASITE040511		Click to Show/Hide the Full List
mod site	chr1:107059009-107059010:+		[6]
Sequence	TTATCCTTGTAGCCAATAAAACATTGACATTCTCACGTTTT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000650338.1; ENST00000649727.1; ENST00000370078.1
External Link	RMBase: m6A_site_42832
mod ID: M6ASITE040512		Click to Show/Hide the Full List
mod site	chr1:107059015-107059016:+		[6]
Sequence	TTGTAGCCAATAAAACATTGACATTCTCACGTTTTATAGAT
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000650338.1; ENST00000370078.1; ENST00000649727.1
External Link	RMBase: m6A_site_42833
mod ID: M6ASITE040513		Click to Show/Hide the Full List
mod site	chr1:107059023-107059024:+		[6]
Sequence	AATAAAACATTGACATTCTCACGTTTTATAGATGAGGTAAA
Motif Score	2.021232143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000649727.1; ENST00000370078.1; ENST00000650338.1
External Link	RMBase: m6A_site_42834
mod ID: M6ASITE040518		Click to Show/Hide the Full List
mod site	chr1:107059107-107059108:+		[6]
Sequence	ATTATTAGTTCTTAAGTGTTACAGCCCCTTCAGAATATAAC
Motif Score	2.07285119
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000370078.1; ENST00000650338.1; ENST00000649727.1
External Link	RMBase: m6A_site_42835
mod ID: M6ASITE040529		Click to Show/Hide the Full List
mod site	chr1:107059134-107059135:+		[6]
Sequence	CTTCAGAATATAACTTCAGGACAATTCAAACTATGCTTAAT
Motif Score	3.643047619
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000649727.1; ENST00000370078.1; ENST00000650338.1
External Link	RMBase: m6A_site_42836
mod ID: M6ASITE040540		Click to Show/Hide the Full List
mod site	chr1:107059143-107059144:+		[6]
Sequence	ATAACTTCAGGACAATTCAAACTATGCTTAATGTATGATTT
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000649727.1; ENST00000370078.1; ENST00000650338.1
External Link	RMBase: m6A_site_42837
mod ID: M6ASITE040551		Click to Show/Hide the Full List
mod site	chr1:107059200-107059201:+		[6]
Sequence	TAAGAAAATAGGTGTGAAAAACTGGTGTTCTGAAATAGCCT
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000649727.1; ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m6A_site_42838
mod ID: M6ASITE040562		Click to Show/Hide the Full List
mod site	chr1:107059222-107059223:+		[7]
Sequence	TGGTGTTCTGAAATAGCCTAACATTTATTGTAATTCTGAAT
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000650338.1; ENST00000370078.1; ENST00000649727.1
External Link	RMBase: m6A_site_42839
mod ID: M6ASITE040570		Click to Show/Hide the Full List
mod site	chr1:107060355-107060356:+		[9]
Sequence	TGTCCAATCTGTCTGTATGGACTGGTACTGACTGCTTGGTG
Motif Score	4.065041667
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000649727.1; ENST00000650338.1
External Link	RMBase: m6A_site_42840
mod ID: M6ASITE040571		Click to Show/Hide the Full List
mod site	chr1:107060383-107060384:+		[9]
Sequence	TGACTGCTTGGTGCCATTGGACCACAGGCAGGAACTACCAG
Motif Score	3.622404762
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000650338.1; ENST00000649727.1
External Link	RMBase: m6A_site_42841
mod ID: M6ASITE040572		Click to Show/Hide the Full List
mod site	chr1:107060396-107060397:+		[9]
Sequence	CCATTGGACCACAGGCAGGAACTACCAGGCCCAAAGGAGAG
Motif Score	3.373380952
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000650338.1; ENST00000649727.1
External Link	RMBase: m6A_site_42842
mod ID: M6ASITE040573		Click to Show/Hide the Full List
mod site	chr1:107060421-107060422:+		[9]
Sequence	CAGGCCCAAAGGAGAGGAAAACATGGTAAAGTTCAACCTGC
Motif Score	2.20572619
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000650338.1; ENST00000649727.1
External Link	RMBase: m6A_site_42843

N7-methylguanosine (m7G)

In total 1 m6A sequence/site(s) in this target gene
mod ID: m7GSITE000060		Click to Show/Hide the Full List
mod site	chr1:107057911-107057912:+		[10]
Sequence	GGAGAGGCGTAGCGAGGTCGGAGGGGAAAGGGAGATCCCAC
Cell/Tissue List	A549; HeLa; HepG2
Seq Type List	BoRed-seq&m7G-RIP-seq; m7G-seq
Transcript ID List	ENST00000649727.1; ENST00000650338.1; ENST00000370078.1
External Link	RMBase: m7G_site_48

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000137		Click to Show/Hide the Full List
mod site	chr1:107057133-107057134:+		[11]
Sequence	GCACGTCCTGCCGGGACCAGTGGAGACTGTAGAGTTGCCGG
Transcript ID List	ENST00000370078.1; ENST00000650338.1
External Link	RMBase: Pseudo_site_258

Ref 1	Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1401-5. doi: 10.1016/s0960-894x(01)00219-0.
Ref 2	Potential for pharmacokinetic interactions between ambrisentan and cyclosporine. Clin Pharmacol Ther. 2010 Oct;88(4):513-20. doi: 10.1038/clpt.2010.120. Epub 2010 Sep 1.
Ref 3	Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population. Drug Metab Dispos. 2005 May;33(5):630-6. doi: 10.1124/dmd.105.003830. Epub 2005 Feb 16.
Ref 4	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 9	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 10	METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25.
Ref 11	Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat Chem Biol. 2015 Aug;11(8):592-7. doi: 10.1038/nchembio.1836. Epub 2015 Jun 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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