m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01425)
Target Name Lithostathine-1-alpha (REG1A)
Synonyms
Islet cells regeneration factor; Islet of Langerhans regenerating protein; Pancreatic stone protein; Pancreatic thread protein; Regenerating islet-derived protein 1-alpha; Regenerating protein I alpha; ICRF; REG; PSP; PTP; REG-1-alpha
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Gene Name REG1A
Chromosomal Location 2p12
Function
Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
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Gene ID 5967
Uniprot ID
REG1A_HUMAN
HGNC ID
HGNC:9951
KEGG ID
hsa:5967
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03580
 Crosstalk Info 
Epigenetic Regulator Histone acetyltransferase p300 (P300)
Regulated Target Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship Histone modification → m6A
Disease Colorectal cancer
 Disease Info 
Crosstalk ID: M6ACROT03625
 Crosstalk Info 
Epigenetic Regulator N-lysine methyltransferase SMYD2 (SMYD2)
Regulated Target Histone H3 lysine 4 trimethylation (H3K4me3)
Crosstalk relationship Histone modification → m6A
Disease Colorectal cancer
 Disease Info 
References
Ref 1 Antitumor Activity of Amivantamab (JNJ-61186372), an EGFR-MET Bispecific Antibody, in Diverse Models of EGFR Exon 20 Insertion-Driven NSCLC. Cancer Discov. 2020 Aug;10(8):1194-1209. doi: 10.1158/2159-8290.CD-20-0116. Epub 2020 May 15.