m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01407)

Target Name	ribonuclease P RNA component H1 (RPPH1)
Synonyms	H1RNA; RPPH1-1 Click to Show/Hide
Gene Name	RPPH1
Chromosomal Location	14q11.2
Gene ID	85495
HGNC ID	HGNC:19273

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05877		Crosstalk Info
Epigenetic Regulator	Ribonuclease P RNA component H1 (RPPH1)
Regulated Target	Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Crosstalk relationship	m6A → ncRNA
Disease	Breast cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01407)

ribonuclease P RNA component H1 (RPPH1)

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000185		Click to Show/Hide the Full List
mod site	chr14:20343233-20343234:-		[2]
Sequence	CCGCGCGAGGTCAGACTGGGCAGGAGATGCCGTGGACCCCG
Cell/Tissue List	frontalcortex; heart; HEK293T; liver; lung; muscle; spleen; testis; HeLa
Seq Type List	Bisulfite-seq; m5C-RIP-seq
Transcript ID List	ENST00000516869.1; ENST00000554988.1
External Link	RMBase: m5C_site_12314

N6-methyladenosine (m6A)

In total 8 m6A sequence/site(s) in this target gene
mod ID: M6ASITE018552		Click to Show/Hide the Full List
mod site	chr14:20343089-20343090:-		[3]
Sequence	GACCTCATAACCCAATTCAGACTACTCTCCTCCGCCCATTT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000554988.1; ENST00000516869.1
External Link	RMBase: m6A_site_238281
mod ID: M6ASITE018553		Click to Show/Hide the Full List
mod site	chr14:20343108-20343109:-		[3]
Sequence	GGTGAGGTACCCCGCAGGGGACCTCATAACCCAATTCAGAC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; H1A; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000516869.1; ENST00000554988.1
External Link	RMBase: m6A_site_238282
mod ID: M6ASITE018554		Click to Show/Hide the Full List
mod site	chr14:20343161-20343162:-		[4]
Sequence	TTTGCCGGAGCTTGGAACAGACTCACGGCCAGCGAAGTGAG
Motif Score	3.319380952
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000516869.1; ENST00000554988.1
External Link	RMBase: m6A_site_238283
mod ID: M6ASITE018555		Click to Show/Hide the Full List
mod site	chr14:20343165-20343166:-		[3]
Sequence	CTCCTTTGCCGGAGCTTGGAACAGACTCACGGCCAGCGAAG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; H1A; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000554988.1; ENST00000516869.1
External Link	RMBase: m6A_site_238284
mod ID: M6ASITE018556		Click to Show/Hide the Full List
mod site	chr14:20343218-20343219:-		[3]
Sequence	CTGGGCAGGAGATGCCGTGGACCCCGCCCTTCGGGGAGGGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; H1A; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000516869.1; ENST00000554988.1
External Link	RMBase: m6A_site_238285
mod ID: M6ASITE018557		Click to Show/Hide the Full List
mod site	chr14:20343239-20343240:-		[3]
Sequence	GGGGCTCCGCGCGAGGTCAGACTGGGCAGGAGATGCCGTGG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; H1A; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000516869.1; ENST00000554988.1
External Link	RMBase: m6A_site_238286
mod ID: M6ASITE018558		Click to Show/Hide the Full List
mod site	chr14:20343303-20343304:-		[5]
Sequence	TAGGGCCAGAGGCGGCCCTAACAGGGCTCTCCCTGAGCTTC
Motif Score	2.168095238
Cell/Tissue List	HEK293
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000554988.1; ENST00000516869.1
External Link	RMBase: m6A_site_238287
mod ID: M6ASITE018559		Click to Show/Hide the Full List
mod site	chr14:20343325-20343326:-		[3]
Sequence	GTCCCTTGGGAAGGTCTGAGACTAGGGCCAGAGGCGGCCCT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; H1A; MT4; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000516869.1; ENST00000554988.1
External Link	RMBase: m6A_site_238288

Ref 1	MMAE Delivery Using the Bicycle Toxin Conjugate BT5528. Mol Cancer Ther. 2020 Jul;19(7):1385-1394. doi: 10.1158/1535-7163.MCT-19-1092. Epub 2020 May 12.
Ref 2	Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6784-6789. doi: 10.1073/pnas.1817334116. Epub 2019 Mar 14.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 5	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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