m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01002)

Target Name	Prostacyclin synthase (PTGIS)
Synonyms	EC 5.3.99.4; Hydroperoxy icosatetraenoate dehydratase; EC 4.2.1.152; Prostaglandin I2 synthase Click to Show/Hide
Gene Name	PTGIS
Chromosomal Location	20q13.13
Family	Cytochrome P450 family
Function	Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:18032380, PubMed:25623425, PubMed:12372404, PubMed:15115769). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323). Click to Show/Hide
Gene ID	5740
Uniprot ID	PTGIS_HUMAN
HGNC ID	HGNC:9603
KEGG ID	hsa:5740

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: Fat mass and obesity-associated protein (FTO)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05247		Crosstalk Info
Epigenetic Regulator	hsa-miR-607
Regulated Target	FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship	ncRNA → m6A
Disease	Non-small cell lung cancer	Disease Info
Drug	Gefitinib	Drug Info
Crosstalk ID: M6ACROT05261		Crosstalk Info
Epigenetic Regulator	hsa_circ_0072309 (Circ_LIFR)
Regulated Target	hsa-miR-607
Crosstalk relationship	ncRNA → m6A
Disease	Non-small cell lung cancer	Disease Info
Drug	Gefitinib	Drug Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01002)

Prostacyclin synthase (PTGIS)

Adenosine-to-Inosine editing (A-to-I)

In total 16 m6A sequence/site(s) in this target gene
mod ID: A2ISITE010700		Click to Show/Hide the Full List
mod site	chr20:49504530-49504531:-		[2]
Sequence	CAACTGATTTTTGTATTTTTAGTAGAGACGGGGTTTCCCCA
Transcript ID List	ENST00000244043.5
External Link	RMBase: RNA-editing_site_88062
mod ID: A2ISITE010701		Click to Show/Hide the Full List
mod site	chr20:49504934-49504935:-		[2]
Sequence	AGATGGGATTTCACCGTATTAGCCAGGATGGTCTTGATCTC
Transcript ID List	ENST00000244043.5
External Link	RMBase: RNA-editing_site_88063
mod ID: A2ISITE010702		Click to Show/Hide the Full List
mod site	chr20:49504937-49504938:-		[2]
Sequence	TAGAGATGGGATTTCACCGTATTAGCCAGGATGGTCTTGAT
Transcript ID List	ENST00000244043.5
External Link	RMBase: RNA-editing_site_88064
mod ID: A2ISITE010703		Click to Show/Hide the Full List
mod site	chr20:49504974-49504975:-		[3]
Sequence	ACCCGCCACCACACCCGGCTAATTTTTGGATTTTTAGTAGA
Transcript ID List	ENST00000244043.5
External Link	RMBase: RNA-editing_site_88065
mod ID: A2ISITE010704		Click to Show/Hide the Full List
mod site	chr20:49505000-49505001:-		[2]
Sequence	CCTCCTGAGTAGCTGGGACTACAGGCACCCGCCACCACACC
Transcript ID List	ENST00000244043.5
External Link	RMBase: RNA-editing_site_88066
mod ID: A2ISITE010705		Click to Show/Hide the Full List
mod site	chr20:49506469-49506470:-		[3]
Sequence	CACCAGAATTGCTTGAACCCAGGAGGTGGAGGTTGCAGTGA
Transcript ID List	ENST00000244043.5; rmsk_5142614
External Link	RMBase: RNA-editing_site_88067
mod ID: A2ISITE010706		Click to Show/Hide the Full List
mod site	chr20:49526046-49526047:-		[4]
Sequence	GTATTTCAGTTGAACACTTAAGCTTATTGCTTTACATTGAA
Transcript ID List	ENST00000478971.1; ENST00000244043.5
External Link	RMBase: RNA-editing_site_88068
mod ID: A2ISITE010707		Click to Show/Hide the Full List
mod site	chr20:49526047-49526048:-		[4]
Sequence	TGTATTTCAGTTGAACACTTAAGCTTATTGCTTTACATTGA
Transcript ID List	ENST00000478971.1; ENST00000244043.5
External Link	RMBase: RNA-editing_site_88069
mod ID: A2ISITE010708		Click to Show/Hide the Full List
mod site	chr20:49546720-49546721:-		[4]
Sequence	GGCATTTTTATCCTTATTTTACAGATGAGGACACTGAGGCT
Transcript ID List	ENST00000244043.5; ENST00000478971.1
External Link	RMBase: RNA-editing_site_88070
mod ID: A2ISITE010709		Click to Show/Hide the Full List
mod site	chr20:49547550-49547551:-		[4]
Sequence	GTTTGGGTCAGCCACACCTAAATTCAAATCCCAGCCCCATC
Transcript ID List	rmsk_5142746; ENST00000244043.5; ENST00000478971.1
External Link	RMBase: RNA-editing_site_88071
mod ID: A2ISITE010710		Click to Show/Hide the Full List
mod site	chr20:49547551-49547552:-		[4]
Sequence	GGTTTGGGTCAGCCACACCTAAATTCAAATCCCAGCCCCAT
Transcript ID List	ENST00000478971.1; rmsk_5142746; ENST00000244043.5
External Link	RMBase: RNA-editing_site_88072
mod ID: A2ISITE010711		Click to Show/Hide the Full List
mod site	chr20:49552709-49552710:-		[4]
Sequence	TTTTAAGTCCTGGTGCTGTTAAGTTATAGTGTTTGACTCCT
Transcript ID List	ENST00000478971.1; ENST00000244043.5
External Link	RMBase: RNA-editing_site_88073
mod ID: A2ISITE010712		Click to Show/Hide the Full List
mod site	chr20:49552725-49552726:-		[4]
Sequence	TGACTTTCTGTATCGTTTTTAAGTCCTGGTGCTGTTAAGTT
Transcript ID List	ENST00000244043.5; ENST00000478971.1
External Link	RMBase: RNA-editing_site_88074
mod ID: A2ISITE010713		Click to Show/Hide the Full List
mod site	chr20:49552734-49552735:-		[4]
Sequence	ACATCCATGTGACTTTCTGTATCGTTTTTAAGTCCTGGTGC
Transcript ID List	ENST00000244043.5; ENST00000478971.1
External Link	RMBase: RNA-editing_site_88075
mod ID: A2ISITE010714		Click to Show/Hide the Full List
mod site	chr20:49552809-49552810:-		[4]
Sequence	TAATATGTCTAAGTTGTTTTATGTTTTTATTTGCCTAGGAA
Transcript ID List	ENST00000244043.5; ENST00000478971.1
External Link	RMBase: RNA-editing_site_88076
mod ID: A2ISITE010715		Click to Show/Hide the Full List
mod site	chr20:49558907-49558908:-		[4]
Sequence	CCAGCCTGACCAACATGATGAAATCCTGTCTCTACTAAAAA
Transcript ID List	rmsk_5142771; ENST00000244043.5; ENST00000478971.1
External Link	RMBase: RNA-editing_site_88077

N6-methyladenosine (m6A)

In total 29 m6A sequence/site(s) in this target gene
mod ID: M6ASITE053482		Click to Show/Hide the Full List
mod site	chr20:49505793-49505794:-		[5]
Sequence	GGCAGGATATCCCCAGGGAAACCCATCTTCACGCCTGGGTG
Motif Score	2.185083333
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5
External Link	RMBase: m6A_site_535810
mod ID: M6ASITE053483		Click to Show/Hide the Full List
mod site	chr20:49506697-49506698:-		[6]
Sequence	CTGAGTGCACCACCCTTTGAACAAATGTATCAGTGATGAAA
Motif Score	2.951386905
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	rmsk_5142615; ENST00000244043.5
External Link	RMBase: m6A_site_535811
mod ID: M6ASITE053484		Click to Show/Hide the Full List
mod site	chr20:49506741-49506742:-		[6]
Sequence	CATTGTAAGAGGTGGTGGGGACCAGCTAATTGGTCCAACCC
Motif Score	3.622404762
Cell/Tissue List	H1A; H1B; endometrial
Seq Type List	m6A-seq
Transcript ID List	rmsk_5142615; ENST00000244043.5
External Link	RMBase: m6A_site_535812
mod ID: M6ASITE053485		Click to Show/Hide the Full List
mod site	chr20:49506762-49506763:-		[7]
Sequence	TGTTCTAACTCTTAGAAGTGACATTGTAAGAGGTGGTGGGG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	rmsk_5142615; ENST00000244043.5
External Link	RMBase: m6A_site_535813
mod ID: M6ASITE053486		Click to Show/Hide the Full List
mod site	chr20:49506786-49506787:-		[6]
Sequence	TGAAGGCATCTGAGTGTGAGACCCTGTTCTAACTCTTAGAA
Motif Score	2.876744048
Cell/Tissue List	H1A; H1B; hESCs; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5; rmsk_5142616
External Link	RMBase: m6A_site_535814
mod ID: M6ASITE053487		Click to Show/Hide the Full List
mod site	chr20:49506809-49506810:-		[6]
Sequence	GCATTCACAGCGCCTCCTGGACCTGAAGGCATCTGAGTGTG
Motif Score	3.622404762
Cell/Tissue List	H1A; H1B; hESCs; endometrial
Seq Type List	m6A-seq
Transcript ID List	rmsk_5142616; ENST00000244043.5
External Link	RMBase: m6A_site_535815
mod ID: M6ASITE053488		Click to Show/Hide the Full List
mod site	chr20:49506874-49506875:-		[7]
Sequence	AGCCGCCTCCCTTATGCAGGACATGTGCTCTCGGCTTCACC
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; H1A; H1B
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000244043.5; rmsk_5142616
External Link	RMBase: m6A_site_535816
mod ID: M6ASITE053489		Click to Show/Hide the Full List
mod site	chr20:49506960-49506961:-		[6]
Sequence	ATGTCCAGCTTCTCTTGAAAACTTGGTATATCTGGCCACAC
Motif Score	2.627720238
Cell/Tissue List	H1B; H1A; fibroblasts
Seq Type List	m6A-seq
Transcript ID List	rmsk_5142616; ENST00000244043.5
External Link	RMBase: m6A_site_535817
mod ID: M6ASITE053490		Click to Show/Hide the Full List
mod site	chr20:49507035-49507036:-		[6]
Sequence	TGCAGACGTGTTTTGTTTGGACTTCACTTAAAAAAATGCCT
Motif Score	4.065041667
Cell/Tissue List	H1A; H1B; fibroblasts; MM6; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000244043.5; rmsk_5142616
External Link	RMBase: m6A_site_535818
mod ID: M6ASITE053491		Click to Show/Hide the Full List
mod site	chr20:49507132-49507133:-		[6]
Sequence	AGCCAGCCAGGACTCCTTAGACTGATCAAGCCAAAAAAGAA
Motif Score	3.319380952
Cell/Tissue List	H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; Huh7; GSC-11; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000244043.5
External Link	RMBase: m6A_site_535819
mod ID: M6ASITE053492		Click to Show/Hide the Full List
mod site	chr20:49507141-49507142:-		[6]
Sequence	GCTGGAAGGAGCCAGCCAGGACTCCTTAGACTGATCAAGCC
Motif Score	4.065041667
Cell/Tissue List	H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; Huh7; GSC-11; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000244043.5
External Link	RMBase: m6A_site_535820
mod ID: M6ASITE053493		Click to Show/Hide the Full List
mod site	chr20:49507169-49507170:-		[6]
Sequence	CTAAGGAAGACACAGCCCAGACAAGATGGCTGGAAGGAGCC
Motif Score	2.897386905
Cell/Tissue List	H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; GSC-11; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000244043.5
External Link	RMBase: m6A_site_535821
mod ID: M6ASITE053494		Click to Show/Hide the Full List
mod site	chr20:49507180-49507181:-		[6]
Sequence	CAGGTAGGGAGCTAAGGAAGACACAGCCCAGACAAGATGGC
Motif Score	2.897386905
Cell/Tissue List	H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; GSC-11; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000244043.5
External Link	RMBase: m6A_site_535822
mod ID: M6ASITE053495		Click to Show/Hide the Full List
mod site	chr20:49507280-49507281:-		[6]
Sequence	AGAACAGGGGCACCCTCCAAACACTGGGCTCTGAGGAGTGG
Motif Score	2.20572619
Cell/Tissue List	H1B; endometrial; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5
External Link	RMBase: m6A_site_535823
mod ID: M6ASITE053496		Click to Show/Hide the Full List
mod site	chr20:49507297-49507298:-		[5]
Sequence	TGATGCATTCCCGGTGCAGAACAGGGGCACCCTCCAAACAC
Motif Score	2.951386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5
External Link	RMBase: m6A_site_535824
mod ID: M6ASITE053497		Click to Show/Hide the Full List
mod site	chr20:49507735-49507736:-		[6]
Sequence	AGAGGGTGAACAAAGAAAAGACATTGAAAGCTCTATGGATT
Motif Score	2.897386905
Cell/Tissue List	H1A; H1B; hNPCs; hESCs; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5
External Link	RMBase: m6A_site_535825
mod ID: M6ASITE053498		Click to Show/Hide the Full List
mod site	chr20:49507746-49507747:-		[6]
Sequence	GGGAAAAGCTAAGAGGGTGAACAAAGAAAAGACATTGAAAG
Motif Score	2.951386905
Cell/Tissue List	H1A; H1B; hNPCs; hESCs; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5
External Link	RMBase: m6A_site_535826
mod ID: M6ASITE053499		Click to Show/Hide the Full List
mod site	chr20:49507955-49507956:-		[5]
Sequence	TTCGGTCTGATGCAGCCGGAACACGACGTGCCCGTCCGCTA
Motif Score	2.951386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5; ENST00000478971.1
External Link	RMBase: m6A_site_535827
mod ID: M6ASITE053500		Click to Show/Hide the Full List
mod site	chr20:49511129-49511130:-		[5]
Sequence	TGACGGATCAGAGAAGAAAGACTTTTACAAGGATGGGAAAC
Motif Score	3.319380952
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000478971.1; ENST00000244043.5
External Link	RMBase: m6A_site_535828
mod ID: M6ASITE053501		Click to Show/Hide the Full List
mod site	chr20:49511153-49511154:-		[5]
Sequence	TAAATACAACCGATTCCTGAACCCTGACGGATCAGAGAAGA
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5; ENST00000478971.1
External Link	RMBase: m6A_site_535829
mod ID: M6ASITE053502		Click to Show/Hide the Full List
mod site	chr20:49513086-49513087:-		[5]
Sequence	AGACCCAGAAATCTACACAGACCCAGAGGTAAATGGCAGGG
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000478971.1; ENST00000244043.5
External Link	RMBase: m6A_site_535830
mod ID: M6ASITE053503		Click to Show/Hide the Full List
mod site	chr20:49513104-49513105:-		[5]
Sequence	CTTCCTGAGCCCCCAGAGAGACCCAGAAATCTACACAGACC
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5; ENST00000478971.1
External Link	RMBase: m6A_site_535831
mod ID: M6ASITE053504		Click to Show/Hide the Full List
mod site	chr20:49513194-49513195:-		[5]
Sequence	CACCCGCGAGGTTGTGGTGGACCTGGCCATGCCCATGGCAG
Motif Score	3.622404762
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5; ENST00000478971.1
External Link	RMBase: m6A_site_535832
mod ID: M6ASITE053505		Click to Show/Hide the Full List
mod site	chr20:49514243-49514244:-		[5]
Sequence	TCTCCCACAGAAGGTTCTAGACAGCACACCTGTGCTTGGTG
Motif Score	2.897386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000478971.1; ENST00000244043.5
External Link	RMBase: m6A_site_535833
mod ID: M6ASITE053506		Click to Show/Hide the Full List
mod site	chr20:49524229-49524230:-		[5]
Sequence	TGTCCCTGCAGGGGACAAGGACCACATGTGCAGTGTCAAAA
Motif Score	3.622404762
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5; ENST00000478971.1
External Link	RMBase: m6A_site_535834
mod ID: M6ASITE053507		Click to Show/Hide the Full List
mod site	chr20:49524235-49524236:-		[5]
Sequence	GTGCTCTGTCCCTGCAGGGGACAAGGACCACATGTGCAGTG
Motif Score	3.643047619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5; ENST00000478971.1
External Link	RMBase: m6A_site_535835
mod ID: M6ASITE053508		Click to Show/Hide the Full List
mod site	chr20:49539594-49539595:-		[5]
Sequence	CTCGACCGGCTGCTCCCCAAACTGGCCCGTGGCTCCCTGTC
Motif Score	2.627720238
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000478971.1; ENST00000244043.5
External Link	RMBase: m6A_site_535836
mod ID: M6ASITE053509		Click to Show/Hide the Full List
mod site	chr20:49539655-49539656:-		[5]
Sequence	CCATGAAAGCCAGGCCCAGGACCGCGTCCACTCAGCTGATG
Motif Score	3.622404762
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244043.5; ENST00000478971.1
External Link	RMBase: m6A_site_535837
mod ID: M6ASITE053510		Click to Show/Hide the Full List
mod site	chr20:49550165-49550166:-		[5]
Sequence	ACCTGGTGAGCCTCCCCTGGACCTGGGCAGCATCCCCTGGT
Motif Score	3.622404762
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000478971.1; ENST00000244043.5
External Link	RMBase: m6A_site_535838

Ref 1	Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106. doi: 10.2147/PGPM.S86013. eCollection 2016.
Ref 2	Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol. 2004 Aug;22(8):1001-5. doi: 10.1038/nbt996. Epub 2004 Jul 18.
Ref 3	Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res. 2012 Jan;22(1):142-50. doi: 10.1101/gr.124107.111. Epub 2011 Sep 29.
Ref 4	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 5	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 6	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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