m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00860)

Target Name	ATP8B1 antisense RNA 1 (ATP8B1-AS1)
Synonyms	RP11-35G9.3 Click to Show/Hide
Gene Name	ATP8B1-AS1
Chromosomal Location	18q21.31
Gene ID	100505549
HGNC ID	HGNC:56042

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Histone modification

m6A Regulator: YTH domain-containing protein 1 (YTHDC1)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03192		Crosstalk Info
Epigenetic Regulator	Lysine-specific demethylase 3B (KDM3B)
Regulated Target	Histone H3 lysine 9 dimethylation (H3K9me2)
Crosstalk relationship	m6A → Histone modification
Disease	Liver cancer	Disease Info
Crosstalk ID: M6ACROT03488		Crosstalk Info
Epigenetic Regulator	Histone acetyltransferase p300 (P300)
Regulated Target	Histone H3 lysine 18 lactylation (H3K18la)
Crosstalk relationship	Histone modification → m6A
Disease	Liver cancer	Disease Info

Non-coding RNA

m6A Regulator: YTH domain-containing protein 1 (YTHDC1)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05663		Crosstalk Info
Epigenetic Regulator	ATP8B1 antisense RNA 1 (ATP8B1-AS1)
Regulated Target	Myc proto-oncogene protein (MYC)
Crosstalk relationship	m6A → ncRNA
Disease	Liver cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00860)

ATP8B1 antisense RNA 1 (ATP8B1-AS1)

Adenosine-to-Inosine editing (A-to-I)

In total 17 m6A sequence/site(s) in this target gene
mod ID: A2ISITE008649		Click to Show/Hide the Full List
mod site	chr18:57637806-57637807:+		[2]
Sequence	CCTCAGCCTCCCGATTAGCTAGGACTACAGGCACCCACCAC
Transcript ID List	ENST00000592201.1; ENST00000591854.5
External Link	RMBase: RNA-editing_site_63613
mod ID: A2ISITE008650		Click to Show/Hide the Full List
mod site	chr18:57658258-57658259:+		[3]
Sequence	GGGGTTTCATCATGTTGGCCAGGCTGGTCTCGAACTCCCAA
Transcript ID List	ENST00000592201.1; ENST00000588925.5; ENST00000619899.1; ENST00000591854.5
External Link	RMBase: RNA-editing_site_63628
mod ID: A2ISITE008651		Click to Show/Hide the Full List
mod site	chr18:57658277-57658278:+		[3]
Sequence	CAGGCTGGTCTCGAACTCCCAACCTCAGGTGATCTGCCTGC
Transcript ID List	ENST00000588925.5; ENST00000592201.1; ENST00000591854.5; ENST00000619899.1
External Link	RMBase: RNA-editing_site_63629
mod ID: A2ISITE008652		Click to Show/Hide the Full List
mod site	chr18:57658278-57658279:+		[3]
Sequence	AGGCTGGTCTCGAACTCCCAACCTCAGGTGATCTGCCTGCC
Transcript ID List	ENST00000591854.5; ENST00000592201.1; ENST00000619899.1; ENST00000588925.5
External Link	RMBase: RNA-editing_site_63630
mod ID: A2ISITE008653		Click to Show/Hide the Full List
mod site	chr18:57658323-57658324:+		[3]
Sequence	CCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGCC
Transcript ID List	ENST00000588925.5; ENST00000591854.5; ENST00000592201.1; ENST00000619899.1
External Link	RMBase: RNA-editing_site_63631
mod ID: A2ISITE008654		Click to Show/Hide the Full List
mod site	chr18:57658329-57658330:+		[3]
Sequence	AAAGTGCTGGGATTACAGGCATGAGCCACCATGCCCCACCT
Transcript ID List	ENST00000588925.5; ENST00000619899.1; ENST00000591854.5; ENST00000592201.1
External Link	RMBase: RNA-editing_site_63632
mod ID: A2ISITE008655		Click to Show/Hide the Full List
mod site	chr18:57658751-57658752:+		[3]
Sequence	CATGGCTCACTGTAGTCTCAACTTCTCAGGCTCAAGTAATC
Transcript ID List	ENST00000591854.5; ENST00000592201.1; ENST00000619899.1; ENST00000588925.5
External Link	RMBase: RNA-editing_site_63633
mod ID: A2ISITE008656		Click to Show/Hide the Full List
mod site	chr18:57659020-57659021:+		[3]
Sequence	TGAGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGACT
Transcript ID List	ENST00000588925.5; ENST00000619899.1; ENST00000591854.5; ENST00000592201.1; rmsk_4872749
External Link	RMBase: RNA-editing_site_63634
mod ID: A2ISITE008657		Click to Show/Hide the Full List
mod site	chr18:57659065-57659066:+		[3]
Sequence	CAGGCAGACTGATTGAGCCCAGGAGTTCAAGACCAGCCTGA
Transcript ID List	ENST00000591854.5; rmsk_4872749; ENST00000619899.1; ENST00000588925.5; ENST00000592201.1
External Link	RMBase: RNA-editing_site_63635
mod ID: A2ISITE008658		Click to Show/Hide the Full List
mod site	chr18:57659110-57659111:+		[3]
Sequence	CATGGCAAATTCCCAACTCTACAAAAAATACAAAAATTAGC
Transcript ID List	ENST00000591854.5; ENST00000588925.5; ENST00000592201.1; ENST00000619899.1; rmsk_4872749
External Link	RMBase: RNA-editing_site_63636
mod ID: A2ISITE008659		Click to Show/Hide the Full List
mod site	chr18:57659113-57659114:+		[3]
Sequence	GGCAAATTCCCAACTCTACAAAAAATACAAAAATTAGCTGG
Transcript ID List	ENST00000592201.1; rmsk_4872749; ENST00000588925.5; ENST00000619899.1; ENST00000591854.5
External Link	RMBase: RNA-editing_site_63637
mod ID: A2ISITE008660		Click to Show/Hide the Full List
mod site	chr18:57659119-57659120:+		[3]
Sequence	TTCCCAACTCTACAAAAAATACAAAAATTAGCTGGGCATGG
Transcript ID List	ENST00000592201.1; ENST00000619899.1; ENST00000591854.5; rmsk_4872749; ENST00000588925.5
External Link	RMBase: RNA-editing_site_63638
mod ID: A2ISITE008661		Click to Show/Hide the Full List
mod site	chr18:57659136-57659137:+		[3]
Sequence	AATACAAAAATTAGCTGGGCATGGTGGCTCATGCCTGTAGT
Transcript ID List	rmsk_4872749; ENST00000588925.5; ENST00000619899.1; ENST00000591854.5; ENST00000592201.1
External Link	RMBase: RNA-editing_site_63639
mod ID: A2ISITE008662		Click to Show/Hide the Full List
mod site	chr18:57659200-57659201:+		[3]
Sequence	TGGGAGGATTGTTTGAGGCCAGGAGGTGGAGGTTGCAGTAA
Transcript ID List	rmsk_4872749; ENST00000619899.1; ENST00000588925.5; ENST00000592201.1; ENST00000591854.5
External Link	RMBase: RNA-editing_site_63640
mod ID: A2ISITE008663		Click to Show/Hide the Full List
mod site	chr18:57659219-57659220:+		[3]
Sequence	CAGGAGGTGGAGGTTGCAGTAAGCCAAGGTCATGCCACTGC
Transcript ID List	ENST00000592201.1; ENST00000591854.5; ENST00000588925.5; ENST00000619899.1; rmsk_4872749
External Link	RMBase: RNA-editing_site_63641
mod ID: A2ISITE008664		Click to Show/Hide the Full List
mod site	chr18:57659225-57659226:+		[3]
Sequence	GTGGAGGTTGCAGTAAGCCAAGGTCATGCCACTGCACCCCA
Transcript ID List	rmsk_4872749; ENST00000592201.1; ENST00000619899.1; ENST00000591854.5; ENST00000588925.5
External Link	RMBase: RNA-editing_site_63642
mod ID: A2ISITE008665		Click to Show/Hide the Full List
mod site	chr18:57663748-57663749:+		[4]
Sequence	TTGGAAAAATGTCTACTCAAAGTGCTTTGCCCATTTTTTTT
Transcript ID List	ENST00000592201.1; ENST00000591854.5; ENST00000619899.1; ENST00000588925.5
External Link	RMBase: RNA-editing_site_63643

N6-methyladenosine (m6A)

In total 26 m6A sequence/site(s) in this target gene
mod ID: M6ASITE037442		Click to Show/Hide the Full List
mod site	chr18:57630422-57630423:+		[5]
Sequence	GGCTCGCCCTAGTCGCGGGGACACCGCCTTCCAGGAGCTGT
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000592201.1; ENST00000591854.5
External Link	RMBase: m6A_site_402376
mod ID: M6ASITE037443		Click to Show/Hide the Full List
mod site	chr18:57630453-57630454:+		[5]
Sequence	CAGGAGCTGTCCCCAGGCAAACTCACAGACATCTTCAAAGA
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000592201.1; ENST00000591854.5
External Link	RMBase: m6A_site_402377
mod ID: M6ASITE037444		Click to Show/Hide the Full List
mod site	chr18:57630461-57630462:+		[5]
Sequence	GTCCCCAGGCAAACTCACAGACATCTTCAAAGAGCCTTCTT
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000592201.1; ENST00000591854.5
External Link	RMBase: m6A_site_402378
mod ID: M6ASITE037445		Click to Show/Hide the Full List
mod site	chr18:57630484-57630485:+		[5]
Sequence	TCTTCAAAGAGCCTTCTTGGACATTCTGCTTTTTGCTCCTC
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000591854.5; ENST00000592201.1
External Link	RMBase: m6A_site_402379
mod ID: M6ASITE037446		Click to Show/Hide the Full List
mod site	chr18:57668045-57668046:+		[5]
Sequence	GCAATAAAATTGGCAAGAAAACCAAAGTTATTGTTCAGTAC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000619899.1; ENST00000588925.5; ENST00000592201.1
External Link	RMBase: m6A_site_402401
mod ID: M6ASITE037447		Click to Show/Hide the Full List
mod site	chr18:57668114-57668115:+		[5]
Sequence	AATGTCAAAGCACTGGAAGGACAGAGGGACAAGAGGGATGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; H1B; H1A; hESCs; A549; GM12878; Huh7; HEK293A-TOA; iSLK; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000588925.5; ENST00000619899.1; ENST00000592201.1
External Link	RMBase: m6A_site_402402
mod ID: M6ASITE037448		Click to Show/Hide the Full List
mod site	chr18:57668122-57668123:+		[5]
Sequence	AGCACTGGAAGGACAGAGGGACAAGAGGGATGGCCCTTTCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; H1B; H1A; hESCs; A549; GM12878; Huh7; HEK293A-TOA; iSLK; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000588925.5; ENST00000592201.1; ENST00000619899.1
External Link	RMBase: m6A_site_402403
mod ID: M6ASITE037449		Click to Show/Hide the Full List
mod site	chr18:57668151-57668152:+		[5]
Sequence	ATGGCCCTTTCAGGACGGGAACCCACGTCTGGCTGGAGAGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; A549; U2OS; H1B; H1A; hESCs; GM12878; LCLs; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592201.1; ENST00000588925.5; ENST00000619899.1
External Link	RMBase: m6A_site_402404
mod ID: M6ASITE037450		Click to Show/Hide the Full List
mod site	chr18:57668176-57668177:+		[5]
Sequence	CGTCTGGCTGGAGAGATAAGACCAATTATAATCAGCAAGAC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; A549; U2OS; H1B; H1A; hESCs; GM12878; LCLs; CD8T; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000592201.1; ENST00000588925.5
External Link	RMBase: m6A_site_402405
mod ID: M6ASITE037451		Click to Show/Hide the Full List
mod site	chr18:57668195-57668196:+		[5]
Sequence	GACCAATTATAATCAGCAAGACATGGCCAGGAGCTAAATTA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; GM12878; LCLs; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592201.1; ENST00000588925.5
External Link	RMBase: m6A_site_402406
mod ID: M6ASITE037452		Click to Show/Hide the Full List
mod site	chr18:57668226-57668227:+		[5]
Sequence	AGCTAAATTATAAGGAAGAAACTGCTACTGAGGGGGATCAG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; GM12878; LCLs; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592201.1; ENST00000588925.5
External Link	RMBase: m6A_site_402407
mod ID: M6ASITE037453		Click to Show/Hide the Full List
mod site	chr18:57668276-57668277:+		[5]
Sequence	CAGAAGAATGTGCTGGAAAAACAGAGGAGGGTTTCTCAGAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000588925.5; ENST00000592201.1
External Link	RMBase: m6A_site_402408
mod ID: M6ASITE037454		Click to Show/Hide the Full List
mod site	chr18:57668319-57668320:+		[5]
Sequence	AGCATCTTCCGTCCAAAGAAACAGTGTTTGTACAGGATGAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000588925.5; ENST00000592201.1
External Link	RMBase: m6A_site_402409
mod ID: M6ASITE037455		Click to Show/Hide the Full List
mod site	chr18:57668496-57668497:+		[5]
Sequence	GTTTTGAAATGGTTTCTGGAACTCCATCCTGTAGCTTGTCT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592201.1; ENST00000588925.5
External Link	RMBase: m6A_site_402413
mod ID: M6ASITE037456		Click to Show/Hide the Full List
mod site	chr18:57668581-57668582:+		[5]
Sequence	AAAAAAAAAGGAATTAGCAAACAAACCAAAAGTTTTCTGTA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592201.1; ENST00000588925.5
External Link	RMBase: m6A_site_402415
mod ID: M6ASITE037457		Click to Show/Hide the Full List
mod site	chr18:57668718-57668719:+		[6]
Sequence	ATGTTTCACAATTACTGCAAACCAACACACCTAAAAACTTT
Motif Score	2.185083333
Cell/Tissue List	HEK293T; GM12878; Huh7; HEK293A-TOA; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000592201.1; ENST00000588925.5
External Link	RMBase: m6A_site_402416
mod ID: M6ASITE037458		Click to Show/Hide the Full List
mod site	chr18:57668734-57668735:+		[7]
Sequence	GCAAACCAACACACCTAAAAACTTTTTCCCTAAAGGATGAA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; HeLa; fibroblasts; GM12878; Huh7; HEK293A-TOA; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000588925.5; ENST00000592201.1
External Link	RMBase: m6A_site_402417
mod ID: M6ASITE037459		Click to Show/Hide the Full List
mod site	chr18:57668754-57668755:+		[7]
Sequence	ACTTTTTCCCTAAAGGATGAACTATTTAATTTACCAAGACA
Motif Score	3.373380952
Cell/Tissue List	HEK293T; HeLa; fibroblasts; GM12878; A549; Huh7; HEK293A-TOA; TIME
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000588925.5; ENST00000592201.1
External Link	RMBase: m6A_site_402418
mod ID: M6ASITE037460		Click to Show/Hide the Full List
mod site	chr18:57668772-57668773:+		[7]
Sequence	GAACTATTTAATTTACCAAGACAAAAATGCAAGTACAAAAT
Motif Score	2.897386905
Cell/Tissue List	HEK293T; HeLa; fibroblasts; GM12878; Huh7; HEK293A-TOA; iSLK; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000588925.5; ENST00000592201.1
External Link	RMBase: m6A_site_402419
mod ID: M6ASITE037461		Click to Show/Hide the Full List
mod site	chr18:57668848-57668849:+		[8]
Sequence	GTGGCTTTATACTGACATAAACCGTAAACCAGTTGCAATAC
Motif Score	2.185083333
Cell/Tissue List	HEK293T; GM12878; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000592201.1; ENST00000588925.5
External Link	RMBase: m6A_site_402420
mod ID: M6ASITE037462		Click to Show/Hide the Full List
mod site	chr18:57668855-57668856:+		[8]
Sequence	TATACTGACATAAACCGTAAACCAGTTGCAATACTAGCTAT
Motif Score	2.185083333
Cell/Tissue List	HEK293T; GM12878; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000588925.5; ENST00000592201.1
External Link	RMBase: m6A_site_402421
mod ID: M6ASITE037463		Click to Show/Hide the Full List
mod site	chr18:57668902-57668903:+		[9]
Sequence	AATATTTTCCACTTATCTAAACCCTACAAAAACTATGTATT
Motif Score	2.185083333
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000588925.5; ENST00000592201.1
External Link	RMBase: m6A_site_402422
mod ID: M6ASITE037464		Click to Show/Hide the Full List
mod site	chr18:57668913-57668914:+		[9]
Sequence	CTTATCTAAACCCTACAAAAACTATGTATTAAATTTGGAAA
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000592201.1; ENST00000588925.5
External Link	RMBase: m6A_site_402423
mod ID: M6ASITE037465		Click to Show/Hide the Full List
mod site	chr18:57668934-57668935:+		[9]
Sequence	CTATGTATTAAATTTGGAAAACTTTTAGAAACAATATATTT
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000592201.1; ENST00000588925.5
External Link	RMBase: m6A_site_402424
mod ID: M6ASITE037466		Click to Show/Hide the Full List
mod site	chr18:57668944-57668945:+		[9]
Sequence	AATTTGGAAAACTTTTAGAAACAATATATTTTTCTTATTTC
Motif Score	2.20572619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000592201.1; ENST00000588925.5
External Link	RMBase: m6A_site_402425
mod ID: M6ASITE037467		Click to Show/Hide the Full List
mod site	chr18:57669095-57669096:+		[9]
Sequence	AATTATGGAATTAAATTAGAACTTCTCCTAATGTATTTTGT
Motif Score	3.373380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000592201.1; ENST00000588925.5
External Link	RMBase: m6A_site_402426

Ref 1	ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors
Ref 2	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 3	Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res. 2004 Sep;14(9):1719-25. doi: 10.1101/gr.2855504.
Ref 4	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 7	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 8	Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. J Am Chem Soc. 2015 Feb 11;137(5):2107-15. doi: 10.1021/ja513080v. Epub 2015 Feb 2.
Ref 9	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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