m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00779)

Target Name	Serine/arginine-rich splicing factor 7 (SRSF7)
Synonyms	SFRS7; Serine/arginine-rich splicing factor 7 ; Splicing factor 9G8 ; Splicing factor; arginine/serine-rich 7 Click to Show/Hide
Gene Name	SRSF7
Chromosomal Location	2p22.1
Family	Splicing factor SR family
Function	Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. Click to Show/Hide
Gene ID	6432
Uniprot ID	SRSF7_HUMAN
HGNC ID	HGNC:10789
KEGG ID	hsa:6432

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

SRSF7 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]

Regulator Info

*Representative RIP-seq result supporting the interaction between SRSF7 and the regulator*
Cell Line	HEK293T	Homo sapiens
Regulation	logFC: 1.26E+00	GSE90639

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	The gene expression of Serine/arginine-rich splicing factor 7 (SRSF7) is positively correlated with glioblastoma (GBM) cell-specific m6A methylation. The two m6A sites on PDZ-binding kinase (PBK) are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by IGF2BP2.
Responsed Disease	Glioblastoma		ICD-11: 2A00.00	Disease Info
Pathway Response	Spliceosome			hsa03040
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
	U87MG (Astroblastoma cells from human brain)
	LN-229	Glioblastoma	Homo sapiens	CVCL_0393
	A-172	Glioblastoma	Homo sapiens	CVCL_0131
	LN-18	Glioblastoma	Homo sapiens	CVCL_0392
	LN-428	Glioblastoma	Homo sapiens	CVCL_3959
	LN-443	Glioblastoma	Homo sapiens	CVCL_3960
	SNB-19	Astrocytoma	Homo sapiens	CVCL_0535
	T98G	Glioblastoma	Homo sapiens	CVCL_0556
	U-118MG	Astrocytoma	Homo sapiens	CVCL_0633
	U251 (Fibroblasts or fibroblast like cells)
	U-138MG	Astrocytoma	Homo sapiens	CVCL_0020

Brain cancer [ICD-11: 2A00]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	The gene expression of Serine/arginine-rich splicing factor 7 (SRSF7) is positively correlated with glioblastoma (GBM) cell-specific m6A methylation. The two m6A sites on PDZ-binding kinase (PBK) are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by IGF2BP2.
Responsed Disease	Glioblastoma [ICD-11: 2A00.00]
Target Regulator	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)		READER	Regulator Info
Pathway Response	Spliceosome			hsa03040
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
	U87MG (Astroblastoma cells from human brain)
	LN-229	Glioblastoma	Homo sapiens	CVCL_0393
	A-172	Glioblastoma	Homo sapiens	CVCL_0131
	LN-18	Glioblastoma	Homo sapiens	CVCL_0392
	LN-428	Glioblastoma	Homo sapiens	CVCL_3959
	LN-443	Glioblastoma	Homo sapiens	CVCL_3960
	SNB-19	Astrocytoma	Homo sapiens	CVCL_0535
	T98G	Glioblastoma	Homo sapiens	CVCL_0556
	U-118MG	Astrocytoma	Homo sapiens	CVCL_0633
	U251 (Fibroblasts or fibroblast like cells)
	U-138MG	Astrocytoma	Homo sapiens	CVCL_0020

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00779)

Serine/arginine-rich splicing factor 7 (SRSF7)

N4-acetylcytidine (ac4C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000015		Click to Show/Hide the Full List
mod site	chr2:38748630-38748631:-		[3]
Sequence	CACGGTCTAGATCACATTCTCGATCCAGAGGAAGGCGATAC
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000425778.5; ENST00000446327.6; ENST00000487773.1; ENST00000425941.6; ENST00000313117.11; ENST00000409276.5; ENST00000452806.5; ENST00000415527.1; ENST00000443213.5; ENST00000431066.5
External Link	RMBase: ac4C_site_1082
mod ID: AC4SITE000016		Click to Show/Hide the Full List
mod site	chr2:38751244-38751245:-		[3]
Sequence	TCTGTCATCATGTCGCGTTACGGGCGGTACGGAGGAGGTAA
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000313117.11; ENST00000425941.6; ENST00000446327.6; ENST00000431066.5; ENST00000443213.5; ENST00000425778.5; ENST00000409276.5
External Link	RMBase: ac4C_site_1083

2'-O-Methylation (2'-O-Me)

In total 4 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000226		Click to Show/Hide the Full List
mod site	chr2:38750055-38750056:-		[4]
Sequence	TGCCTTTGTGGAATTCGAAGATCCTAGAGATGCAGAAGATG
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000446327.6; ENST00000409276.5; ENST00000415527.1; ENST00000425778.5; ENST00000443213.5; ENST00000425941.6; ENST00000313117.11; ENST00000431066.5
External Link	RMBase: Nm_site_3038
mod ID: 2OMSITE000223		Click to Show/Hide the Full List
mod site	chr2:38748071-38748072:-		[4]
Sequence	TCAGAAGATCTAGGTCTGGTTCTATAAAAGGATCGAGGTAT
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000415527.1; ENST00000452806.5; ENST00000425941.6; ENST00000487773.1; ENST00000431066.5; ENST00000313117.11; ENST00000446327.6; ENST00000425778.5; ENST00000409276.5; ENST00000443213.5; ENST00000432873.5
External Link	RMBase: Nm_site_3035
mod ID: 2OMSITE000224		Click to Show/Hide the Full List
mod site	chr2:38750051-38750052:-		[4]
Sequence	TTTGTGGAATTCGAAGATCCTAGAGATGCAGAAGATGCAGT
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000446327.6; ENST00000313117.11; ENST00000409276.5; ENST00000431066.5; ENST00000425778.5; ENST00000443213.5; ENST00000415527.1; ENST00000425941.6
External Link	RMBase: Nm_site_3036
mod ID: 2OMSITE000225		Click to Show/Hide the Full List
mod site	chr2:38750054-38750055:-		[4]
Sequence	GCCTTTGTGGAATTCGAAGATCCTAGAGATGCAGAAGATGC
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000425778.5; ENST00000313117.11; ENST00000415527.1; ENST00000409276.5; ENST00000431066.5; ENST00000446327.6; ENST00000425941.6; ENST00000443213.5
External Link	RMBase: Nm_site_3037

5-methylcytidine (m5C)

In total 14 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002293		Click to Show/Hide the Full List
mod site	chr2:38750468-38750469:-
Sequence	GGGTGGGGCCGGGCCAGGTTCCGCCCCACGCCTCGGTGTAT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000431066.5; ENST00000446327.6; ENST00000443213.5; ENST00000425778.5; ENST00000425941.6; ENST00000409276.5; ENST00000415527.1; ENST00000313117.11
External Link	RMBase: m5C_site_26357
mod ID: M5CSITE002294		Click to Show/Hide the Full List
mod site	chr2:38750474-38750475:-
Sequence	ACTCATGGGTGGGGCCGGGCCAGGTTCCGCCCCACGCCTCG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000415527.1; ENST00000431066.5; ENST00000313117.11; ENST00000425941.6; ENST00000409276.5; ENST00000443213.5; ENST00000446327.6; ENST00000425778.5
External Link	RMBase: m5C_site_26358
mod ID: M5CSITE002295		Click to Show/Hide the Full List
mod site	chr2:38750475-38750476:-
Sequence	GACTCATGGGTGGGGCCGGGCCAGGTTCCGCCCCACGCCTC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000409276.5; ENST00000431066.5; ENST00000425941.6; ENST00000425778.5; ENST00000443213.5; ENST00000446327.6; ENST00000313117.11; ENST00000415527.1
External Link	RMBase: m5C_site_26359
mod ID: M5CSITE002296		Click to Show/Hide the Full List
mod site	chr2:38750479-38750480:-
Sequence	CCGGGACTCATGGGTGGGGCCGGGCCAGGTTCCGCCCCACG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000443213.5; ENST00000415527.1; ENST00000431066.5; ENST00000425941.6; ENST00000425778.5; ENST00000313117.11; ENST00000409276.5; ENST00000446327.6
External Link	RMBase: m5C_site_26360
mod ID: M5CSITE002297		Click to Show/Hide the Full List
mod site	chr2:38750480-38750481:-
Sequence	GCCGGGACTCATGGGTGGGGCCGGGCCAGGTTCCGCCCCAC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000431066.5; ENST00000415527.1; ENST00000425778.5; ENST00000443213.5; ENST00000409276.5; ENST00000313117.11; ENST00000446327.6; ENST00000425941.6
External Link	RMBase: m5C_site_26361
mod ID: M5CSITE002298		Click to Show/Hide the Full List
mod site	chr2:38750570-38750571:-
Sequence	CTGCTCTCCTGGCCCGGCCCCTACCGAGGCCCTCCCGCCGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000409276.5; ENST00000443213.5; ENST00000425778.5; ENST00000313117.11; ENST00000425941.6; ENST00000415527.1; ENST00000446327.6; ENST00000431066.5
External Link	RMBase: m5C_site_26362
mod ID: M5CSITE002299		Click to Show/Hide the Full List
mod site	chr2:38750571-38750572:-
Sequence	CCTGCTCTCCTGGCCCGGCCCCTACCGAGGCCCTCCCGCCG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000446327.6; ENST00000425778.5; ENST00000431066.5; ENST00000313117.11; ENST00000415527.1; ENST00000425941.6; ENST00000409276.5; ENST00000443213.5
External Link	RMBase: m5C_site_26363
mod ID: M5CSITE002300		Click to Show/Hide the Full List
mod site	chr2:38750572-38750573:-
Sequence	CCCTGCTCTCCTGGCCCGGCCCCTACCGAGGCCCTCCCGCC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000443213.5; ENST00000415527.1; ENST00000431066.5; ENST00000313117.11; ENST00000446327.6; ENST00000425941.6; ENST00000425778.5; ENST00000409276.5
External Link	RMBase: m5C_site_26364
mod ID: M5CSITE002301		Click to Show/Hide the Full List
mod site	chr2:38750573-38750574:-
Sequence	GCCCTGCTCTCCTGGCCCGGCCCCTACCGAGGCCCTCCCGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000431066.5; ENST00000443213.5; ENST00000313117.11; ENST00000415527.1; ENST00000409276.5; ENST00000425941.6; ENST00000446327.6; ENST00000425778.5
External Link	RMBase: m5C_site_26365
mod ID: M5CSITE002302		Click to Show/Hide the Full List
mod site	chr2:38750576-38750577:-
Sequence	GCAGCCCTGCTCTCCTGGCCCGGCCCCTACCGAGGCCCTCC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000415527.1; ENST00000425941.6; ENST00000313117.11; ENST00000431066.5; ENST00000443213.5; ENST00000409276.5; ENST00000425778.5; ENST00000446327.6
External Link	RMBase: m5C_site_26366
mod ID: M5CSITE002303		Click to Show/Hide the Full List
mod site	chr2:38750577-38750578:-
Sequence	CGCAGCCCTGCTCTCCTGGCCCGGCCCCTACCGAGGCCCTC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000425941.6; ENST00000313117.11; ENST00000409276.5; ENST00000431066.5; ENST00000446327.6; ENST00000443213.5; ENST00000415527.1; ENST00000425778.5
External Link	RMBase: m5C_site_26367
mod ID: M5CSITE002304		Click to Show/Hide the Full List
mod site	chr2:38750578-38750579:-
Sequence	GCGCAGCCCTGCTCTCCTGGCCCGGCCCCTACCGAGGCCCT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000313117.11; ENST00000425778.5; ENST00000409276.5; ENST00000446327.6; ENST00000425941.6; ENST00000443213.5; ENST00000431066.5; ENST00000415527.1
External Link	RMBase: m5C_site_26368
mod ID: M5CSITE002305		Click to Show/Hide the Full List
mod site	chr2:38751350-38751351:-		[5]
Sequence	GCTCTTCCTCGTAGTGCCGCCGGGACTCTTGGCGGGTGAAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000409276.5; ENST00000425778.5; ENST00000425941.6; ENST00000313117.11; ENST00000443213.5; ENST00000446327.6
External Link	RMBase: m5C_site_26369
mod ID: M5CSITE002306		Click to Show/Hide the Full List
mod site	chr2:38751351-38751352:-		[5]
Sequence	GGCTCTTCCTCGTAGTGCCGCCGGGACTCTTGGCGGGTGAA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000409276.5; ENST00000446327.6; ENST00000425941.6; ENST00000443213.5; ENST00000313117.11; ENST00000425778.5
External Link	RMBase: m5C_site_26370

N6-methyladenosine (m6A)

In total 49 m6A sequence/site(s) in this target gene
mod ID: M6ASITE044151		Click to Show/Hide the Full List
mod site	chr2:38743627-38743628:-		[6]
Sequence	TTTAAAGATAAGTTTACTCAACAATAAATCTGCAGAGATTG
Motif Score	2.173910714
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000313117.11; ENST00000425778.5; ENST00000446327.6
External Link	RMBase: m6A_site_469154
mod ID: M6ASITE044152		Click to Show/Hide the Full List
mod site	chr2:38743632-38743633:-		[6]
Sequence	TATTATTTAAAGATAAGTTTACTCAACAATAAATCTGCAGA
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000313117.11; ENST00000425778.5; ENST00000446327.6
External Link	RMBase: m6A_site_469155
mod ID: M6ASITE044153		Click to Show/Hide the Full List
mod site	chr2:38743739-38743740:-		[6]
Sequence	GGATTGTTTTTGGAATTTTGACTGGCTGAATTATGGTTGGT
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000446327.6; ENST00000313117.11; ENST00000425778.5
External Link	RMBase: m6A_site_469156
mod ID: M6ASITE044154		Click to Show/Hide the Full List
mod site	chr2:38743784-38743785:-		[6]
Sequence	CAAGTTTATTCGGTAGTTTGACCGCTAGTATGTTGGAAGTT
Motif Score	2.839113095
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000446327.6; ENST00000313117.11; ENST00000425778.5
External Link	RMBase: m6A_site_469157
mod ID: M6ASITE044155		Click to Show/Hide the Full List
mod site	chr2:38743816-38743817:-		[6]
Sequence	TACTATTGCAACTTGGGAATACTGGTCTGCATCAAGTTTAT
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000446327.6; ENST00000425778.5; ENST00000313117.11
External Link	RMBase: m6A_site_469158
mod ID: M6ASITE044156		Click to Show/Hide the Full List
mod site	chr2:38743912-38743913:-		[7]
Sequence	AGGCATTCTCTAGCCTTGGTACAAAAAAAAAAAAACCTGCT
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000313117.11; ENST00000446327.6; ENST00000425778.5
External Link	RMBase: m6A_site_469159
mod ID: M6ASITE044157		Click to Show/Hide the Full List
mod site	chr2:38743964-38743965:-		[6]
Sequence	ATAGTAGGGCAGTAACAGTTACTTTTGAGAGTTTTCTGGTC
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000425778.5; ENST00000446327.6; ENST00000313117.11
External Link	RMBase: m6A_site_469160
mod ID: M6ASITE044158		Click to Show/Hide the Full List
mod site	chr2:38743970-38743971:-		[6]
Sequence	TTAAGAATAGTAGGGCAGTAACAGTTACTTTTGAGAGTTTT
Motif Score	2.168095238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000446327.6; ENST00000313117.11; ENST00000425778.5
External Link	RMBase: m6A_site_469161
mod ID: M6ASITE044159		Click to Show/Hide the Full List
mod site	chr2:38744028-38744029:-		[6]
Sequence	CTGGTAGACCTTAGAATGTTACATAGCCAGTAGGTTCTTTA
Motif Score	2.07285119
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000425778.5; ENST00000313117.11; ENST00000446327.6
External Link	RMBase: m6A_site_469162
mod ID: M6ASITE044160		Click to Show/Hide the Full List
mod site	chr2:38744041-38744042:-		[8]
Sequence	TTTTTGGTAGCATCTGGTAGACCTTAGAATGTTACATAGCC
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000313117.11; ENST00000446327.6; ENST00000425778.5
External Link	RMBase: m6A_site_469163
mod ID: M6ASITE044161		Click to Show/Hide the Full List
mod site	chr2:38744079-38744080:-		[6]
Sequence	TCTCAGCTATATTTAGCAACACTCCATGTAGCTAATATTTT
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000446327.6; ENST00000425778.5; ENST00000313117.11
External Link	RMBase: m6A_site_469164
mod ID: M6ASITE044162		Click to Show/Hide the Full List
mod site	chr2:38744081-38744082:-		[7]
Sequence	AATCTCAGCTATATTTAGCAACACTCCATGTAGCTAATATT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000313117.11; ENST00000446327.6; ENST00000425778.5
External Link	RMBase: m6A_site_469165
mod ID: M6ASITE044163		Click to Show/Hide the Full List
mod site	chr2:38744118-38744119:-		[8]
Sequence	CAATCAGAAATGTCAATGAGACTAAAGTGGTTTTGTAAATC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000446327.6; ENST00000313117.11; ENST00000425778.5
External Link	RMBase: m6A_site_469166
mod ID: M6ASITE044164		Click to Show/Hide the Full List
mod site	chr2:38744183-38744184:-		[7]
Sequence	TTTTGCAGTTCCCAACCACAACATTCTTCTATTTTGCCAGG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000313117.11; ENST00000425778.5; ENST00000446327.6
External Link	RMBase: m6A_site_469167
mod ID: M6ASITE044165		Click to Show/Hide the Full List
mod site	chr2:38744186-38744187:-		[7]
Sequence	AGGTTTTGCAGTTCCCAACCACAACATTCTTCTATTTTGCC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000446327.6; ENST00000425778.5; ENST00000313117.11
External Link	RMBase: m6A_site_469168
mod ID: M6ASITE044166		Click to Show/Hide the Full List
mod site	chr2:38744228-38744229:-		[8]
Sequence	TTGTCTTATTCTGAGCAAAGACCTGTTGTTAATCTTCAAGC
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000313117.11; ENST00000446327.6; ENST00000425778.5
External Link	RMBase: m6A_site_469169
mod ID: M6ASITE044167		Click to Show/Hide the Full List
mod site	chr2:38744300-38744301:-		[8]
Sequence	GACAAAACACCTTCATGTAAACCAGCTTTGCAAAATTTTCC
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000313117.11; ENST00000446327.6; ENST00000425778.5
External Link	RMBase: m6A_site_469170
mod ID: M6ASITE044168		Click to Show/Hide the Full List
mod site	chr2:38744314-38744315:-		[8]
Sequence	TTGTCTGAAATTGGGACAAAACACCTTCATGTAAACCAGCT
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000446327.6; ENST00000313117.11; ENST00000425778.5
External Link	RMBase: m6A_site_469171
mod ID: M6ASITE044169		Click to Show/Hide the Full List
mod site	chr2:38744319-38744320:-		[8]
Sequence	AGGAATTGTCTGAAATTGGGACAAAACACCTTCATGTAAAC
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000313117.11; ENST00000425778.5; ENST00000446327.6
External Link	RMBase: m6A_site_469172
mod ID: M6ASITE044170		Click to Show/Hide the Full List
mod site	chr2:38744379-38744380:-		[6]
Sequence	GTCTTGTTTCTTTGCTTTCTACATTAGTTAACCAGTTTTAT
Motif Score	2.078666667
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000446327.6; ENST00000425778.5; ENST00000313117.11
External Link	RMBase: m6A_site_469173
mod ID: M6ASITE044171		Click to Show/Hide the Full List
mod site	chr2:38744500-38744501:-		[7]
Sequence	TAAATGTATGAGAAATAGAAACATTTCTGGATGATCTTTAT
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000313117.11; ENST00000425778.5; ENST00000425941.6; ENST00000446327.6
External Link	RMBase: m6A_site_469174
mod ID: M6ASITE044172		Click to Show/Hide the Full List
mod site	chr2:38744663-38744664:-		[9]
Sequence	TGACCTGAGTCCCTTATGATACAGCCTGAATGCATCATGAC
Motif Score	2.110482143
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000313117.11; ENST00000425778.5; ENST00000446327.6; ENST00000425941.6
External Link	RMBase: m6A_site_469175
mod ID: M6ASITE044173		Click to Show/Hide the Full List
mod site	chr2:38744745-38744746:-		[6]
Sequence	ATCACTATTCTATGCATAAAACTTGGCCAGGATCTTAAGGG
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000452806.5; ENST00000425778.5; ENST00000313117.11; ENST00000425941.6; ENST00000446327.6
External Link	RMBase: m6A_site_469176
mod ID: M6ASITE044174		Click to Show/Hide the Full List
mod site	chr2:38744767-38744768:-		[6]
Sequence	AGGTGTTGGTTAAGTCTTGAACATCACTATTCTATGCATAA
Motif Score	2.951386905
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000452806.5; ENST00000313117.11; ENST00000425778.5; ENST00000425941.6; ENST00000446327.6
External Link	RMBase: m6A_site_469177
mod ID: M6ASITE044175		Click to Show/Hide the Full List
mod site	chr2:38744821-38744822:-		[6]
Sequence	GTCAGACATTATAATTGTTAACCTTATTCATACATACCTAC
Motif Score	2.147452381
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000313117.11; ENST00000425941.6; ENST00000425778.5; ENST00000452806.5; ENST00000446327.6
External Link	RMBase: m6A_site_469178
mod ID: M6ASITE044176		Click to Show/Hide the Full List
mod site	chr2:38744866-38744867:-		[6]
Sequence	GATTTGTGTTCAATATTAACACTTCTTAATTTGATATATTT
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000425941.6; ENST00000425778.5; ENST00000446327.6; ENST00000313117.11; ENST00000452806.5
External Link	RMBase: m6A_site_469179
mod ID: M6ASITE044177		Click to Show/Hide the Full List
mod site	chr2:38744956-38744957:-		[6]
Sequence	AAATTTTGTTGAATGTATTAACATCATATGGTCTGAAAATG
Motif Score	2.168095238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000409276.5; ENST00000431066.5; ENST00000446327.6; ENST00000443213.5; ENST00000432873.5; ENST00000313117.11; ENST00000452806.5; ENST00000477635.5; ENST00000425778.5; ENST00000425941.6
External Link	RMBase: m6A_site_469180
mod ID: M6ASITE044178		Click to Show/Hide the Full List
mod site	chr2:38744994-38744995:-		[9]
Sequence	CTGGATTACTATGTAAATTCACAGCAGTAAGATAATATAAA
Motif Score	2.047297619
Cell/Tissue List	brain; kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000432873.5; ENST00000431066.5; ENST00000443213.5; ENST00000409276.5; ENST00000313117.11; ENST00000477635.5; ENST00000425778.5; ENST00000446327.6; ENST00000425941.6; ENST00000452806.5
External Link	RMBase: m6A_site_469181
mod ID: M6ASITE044179		Click to Show/Hide the Full List
mod site	chr2:38745007-38745008:-		[6]
Sequence	AATCAAAATGGATCTGGATTACTATGTAAATTCACAGCAGT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000477635.5; ENST00000425941.6; ENST00000443213.5; ENST00000432873.5; ENST00000431066.5; ENST00000446327.6; ENST00000452806.5; ENST00000409276.5; ENST00000313117.11; ENST00000425778.5
External Link	RMBase: m6A_site_469182
mod ID: M6ASITE044180		Click to Show/Hide the Full List
mod site	chr2:38745053-38745054:-		[6]
Sequence	TGTGATGTCTGTAAAGTGTAACCTAGGAAAGATAATTCAAC
Motif Score	2.147452381
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000432873.5; ENST00000452806.5; ENST00000431066.5; ENST00000487773.1; ENST00000477635.5; ENST00000446327.6; ENST00000425778.5; ENST00000443213.5; ENST00000425941.6; ENST00000313117.11; ENST00000409276.5
External Link	RMBase: m6A_site_469183
mod ID: M6ASITE044181		Click to Show/Hide the Full List
mod site	chr2:38745091-38745092:-		[6]
Sequence	AGGGAAAAGTTATTTTGTTTACATTATTATAAGGGATTTGT
Motif Score	2.07285119
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000477635.5; ENST00000443213.5; ENST00000452806.5; ENST00000313117.11; ENST00000409276.5; ENST00000425778.5; ENST00000431066.5; ENST00000446327.6; ENST00000487773.1; ENST00000425941.6; ENST00000432873.5
External Link	RMBase: m6A_site_469184
mod ID: M6ASITE044182		Click to Show/Hide the Full List
mod site	chr2:38745136-38745137:-		[10]
Sequence	TGCAAGTCCTGAAAGAATGGACTGAAGCTCTCAAGTTCACC
Motif Score	4.065041667
Cell/Tissue List	HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000452806.5; ENST00000425778.5; ENST00000431066.5; ENST00000432873.5; ENST00000487773.1; ENST00000477635.5; ENST00000446327.6; ENST00000409276.5; ENST00000313117.11; ENST00000425941.6; ENST00000443213.5
External Link	RMBase: m6A_site_469185
mod ID: M6ASITE044183		Click to Show/Hide the Full List
mod site	chr2:38746786-38746787:-		[10]
Sequence	AGTTAAGGAAATTCCTTTGGACTGATTGATATAATTGTGTT
Motif Score	4.065041667
Cell/Tissue List	HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000446327.6; ENST00000432873.5; ENST00000425941.6; ENST00000452806.5; ENST00000409276.5; ENST00000425778.5; ENST00000313117.11; ENST00000431066.5; ENST00000477635.5; ENST00000443213.5; ENST00000487773.1
External Link	RMBase: m6A_site_469186
mod ID: M6ASITE044184		Click to Show/Hide the Full List
mod site	chr2:38748637-38748638:-		[7]
Sequence	AATAGGTCACGGTCTAGATCACATTCTCGATCCAGAGGAAG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000425778.5; ENST00000409276.5; ENST00000452806.5; ENST00000446327.6; ENST00000313117.11; ENST00000425941.6; ENST00000431066.5; ENST00000487773.1; ENST00000443213.5; ENST00000415527.1
External Link	RMBase: m6A_site_469187
mod ID: M6ASITE044185		Click to Show/Hide the Full List
mod site	chr2:38749092-38749093:-		[8]
Sequence	CCTCCGGTTTAGAAAGAGGAACACCAGATTGACCACATTCC
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000313117.11; ENST00000409276.5; ENST00000452806.5; ENST00000415527.1; ENST00000443213.5; ENST00000425941.6; ENST00000431066.5; ENST00000425778.5; ENST00000446327.6
External Link	RMBase: m6A_site_469188
mod ID: M6ASITE044186		Click to Show/Hide the Full List
mod site	chr2:38749246-38749247:-		[8]
Sequence	GACAATTAAGATCCTCCTAGACCTTGAGGTGATCAGCATAA
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000443213.5; ENST00000415527.1; ENST00000313117.11; ENST00000446327.6; ENST00000409276.5; ENST00000431066.5; ENST00000425778.5; ENST00000452806.5; ENST00000425941.6
External Link	RMBase: m6A_site_469189
mod ID: M6ASITE044187		Click to Show/Hide the Full List
mod site	chr2:38749549-38749550:-		[9]
Sequence	TGCTTATGATTGTCATCGTTACAGCCGGCGAAGAAGAAGCA
Motif Score	2.07285119
Cell/Tissue List	HEK293; liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000452806.5; ENST00000409276.5; ENST00000425778.5; ENST00000443213.5; ENST00000425941.6; ENST00000431066.5; ENST00000313117.11; ENST00000446327.6; ENST00000415527.1
External Link	RMBase: m6A_site_469190
mod ID: M6ASITE044188		Click to Show/Hide the Full List
mod site	chr2:38749575-38749576:-		[7]
Sequence	TATGAGTGTGGCGAAAAGGGACATTATGCTTATGATTGTCA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; HepG2; peripheral-blood; AML
Seq Type List	MAZTER-seq; m6A-seq; miCLIP
Transcript ID List	ENST00000431066.5; ENST00000425941.6; ENST00000409276.5; ENST00000425778.5; ENST00000443213.5; ENST00000313117.11; ENST00000446327.6; ENST00000415527.1
External Link	RMBase: m6A_site_469191
mod ID: M6ASITE044189		Click to Show/Hide the Full List
mod site	chr2:38749635-38749636:-		[11]
Sequence	CGGAGATCACGTTTTGATAGACCACCTGCCCGACGTCCCTT
Motif Score	2.876744048
Cell/Tissue List	HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000446327.6; ENST00000443213.5; ENST00000409276.5; ENST00000425778.5; ENST00000431066.5; ENST00000415527.1; ENST00000313117.11; ENST00000425941.6
External Link	RMBase: m6A_site_469192
mod ID: M6ASITE044190		Click to Show/Hide the Full List
mod site	chr2:38749674-38749675:-		[11]
Sequence	GGCTCCCGAGTGAGGGTTGAACTATCGACAGGCATGCCTCG
Motif Score	3.373380952
Cell/Tissue List	HepG2; peripheral-blood; endometrial; AML
Seq Type List	m6A-seq; miCLIP
Transcript ID List	ENST00000425778.5; ENST00000443213.5; ENST00000409276.5; ENST00000431066.5; ENST00000313117.11; ENST00000415527.1; ENST00000446327.6; ENST00000425941.6
External Link	RMBase: m6A_site_469193
mod ID: M6ASITE044191		Click to Show/Hide the Full List
mod site	chr2:38750024-38750025:-		[11]
Sequence	GCAGAAGATGCAGTACGAGGACTGGATGGAAAGTAAGTAAG
Motif Score	4.065041667
Cell/Tissue List	HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000431066.5; ENST00000425778.5; ENST00000446327.6; ENST00000409276.5; ENST00000415527.1; ENST00000313117.11; ENST00000425941.6; ENST00000443213.5
External Link	RMBase: m6A_site_469194
mod ID: M6ASITE044192		Click to Show/Hide the Full List
mod site	chr2:38750107-38750108:-		[12]
Sequence	GTTATTATGGTCCTTTAAGAACTGTATGGATTGCGAGAAAT
Motif Score	3.373380952
Cell/Tissue List	HepG2; A549; peripheral-blood; TIME; iSLK; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000313117.11; ENST00000443213.5; ENST00000425941.6; ENST00000409276.5; ENST00000425778.5; ENST00000415527.1; ENST00000431066.5; ENST00000446327.6
External Link	RMBase: m6A_site_469195
mod ID: M6ASITE044193		Click to Show/Hide the Full List
mod site	chr2:38750164-38750165:-		[8]
Sequence	TGTATGTTGGTAACCTGGGAACTGGCGCTGGCAAAGGAGAG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; DART-seq; MeRIP-seq
Transcript ID List	ENST00000425941.6; ENST00000446327.6; ENST00000443213.5; ENST00000409276.5; ENST00000431066.5; ENST00000313117.11; ENST00000425778.5; ENST00000415527.1
External Link	RMBase: m6A_site_469196
mod ID: M6ASITE044194		Click to Show/Hide the Full List
mod site	chr2:38750191-38750192:-		[8]
Sequence	ATTTGCGTTTTTAAACAGAAACCAAGGTGTATGTTGGTAAC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000443213.5; ENST00000431066.5; ENST00000415527.1; ENST00000409276.5; ENST00000425941.6; ENST00000313117.11; ENST00000425778.5; ENST00000446327.6
External Link	RMBase: m6A_site_469197
mod ID: M6ASITE044195		Click to Show/Hide the Full List
mod site	chr2:38750840-38750841:-		[8]
Sequence	CTTTCCCGCCACTTCAGCGGACAGATCTGGCCGCAGCTGTA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000313117.11; ENST00000443213.5; ENST00000431066.5; ENST00000446327.6; ENST00000425778.5; ENST00000415527.1; ENST00000409276.5; ENST00000425941.6
External Link	RMBase: m6A_site_469198
mod ID: M6ASITE044196		Click to Show/Hide the Full List
mod site	chr2:38750885-38750886:-		[8]
Sequence	CCATTTTGCGCACATTGAGGACCGTGGTGGCGCATTTCCTC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000446327.6; ENST00000313117.11; ENST00000409276.5; ENST00000443213.5; ENST00000431066.5; ENST00000425941.6; ENST00000415527.1; ENST00000425778.5
External Link	RMBase: m6A_site_469199
mod ID: M6ASITE044197		Click to Show/Hide the Full List
mod site	chr2:38751346-38751347:-		[8]
Sequence	TTCCTCGTAGTGCCGCCGGGACTCTTGGCGGGTGAAGGTGT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; H1B; H1A; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000425941.6; ENST00000409276.5; ENST00000446327.6; ENST00000313117.11; ENST00000425778.5; ENST00000443213.5
External Link	RMBase: m6A_site_469200
mod ID: M6ASITE044198		Click to Show/Hide the Full List
mod site	chr2:38751376-38751377:-		[8]
Sequence	GGCCGCATATATAAACGCGAACCCGGGCTCTTCCTCGTAGT
Motif Score	2.930744048
Cell/Tissue List	HeLa; H1B; A549; HEK293A-TOA; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000425778.5; ENST00000446327.6
External Link	RMBase: m6A_site_469201
mod ID: M6ASITE044199		Click to Show/Hide the Full List
mod site	chr2:38751427-38751428:-		[8]
Sequence	GCTCCTTTGTGCCGCGCAGAACAACGAGATGACGCATGCGC
Motif Score	2.951386905
Cell/Tissue List	HeLa; A549; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000446327.6
External Link	RMBase: m6A_site_469202

Ref 1	Specific Regulation of m(6)A by SRSF7 Promotes the Progression of Glioblastoma. Genomics Proteomics Bioinformatics. 2021 Dec 23:S1672-0229(21)00252-7. doi: 10.1016/j.gpb.2021.11.001. Online ahead of print.
Ref 2	Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67.
Ref 3	NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Res. 2023 Sep 8;51(16):8514-8531. doi: 10.1093/nar/gkad628.
Ref 4	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.
Ref 5	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 6	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 9	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 10	Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016 Nov 9;20(5):666-673. doi: 10.1016/j.chom.2016.10.002. Epub 2016 Oct 20.
Ref 11	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 12	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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