m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00769)

Target Name	Keratin, type II cytoskeletal 7 (KRT7)
Synonyms	SCL; Keratin; type II cytoskeletal 7 ; Cytokeratin-7; CK-7 ; Keratin-7; K7 ; Sarcolectin ; Type-II keratin Kb7 Click to Show/Hide
Gene Name	KRT7
Chromosomal Location	12q13.13
Family	Intermediate filament family
Function	Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Click to Show/Hide
Gene ID	3855
Uniprot ID	K2C7_HUMAN
HGNC ID	HGNC:6445
KEGG ID	hsa:3855

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

KRT7 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RIP-seq result supporting the interaction between KRT7 and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 1.21E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	Specifically, increased METTL3 methylated KRT7-AS at A877 to increase the stability of a KRT7-AS/Keratin, type II cytoskeletal 7 (KRT7) mRNA duplex via IGF2BP1/HuR complexes. m6A promotes breast cancer lung metastasis by increasing the stability of a KRT7-AS/KRT7 mRNA duplex and translation of KRT7.
Target Regulation	Up regulation
Responsed Disease	Breast cancer		ICD-11: 2C60	Disease Info
Cell Process	Lung Metastasis
In-vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens	CVCL_0062
In-vitro Model	BT-549	Invasive breast carcinoma	Homo sapiens	CVCL_1092
In-vivo Model	First, subcutaneous transplanted model was used to evaluate the growth of BT-549LMF3 and BT-549 cells. Cells (5 × 10⁶ per mouse, n = 5 for each group) were diluted in 200 ul PBS + 200 ul Matrigel (BD Biosciences) and subcutaneously injected into immunodeficient female mice. Second, subcutaneous transplanted model was used to evaluate the metastasis potential of BT-549LMF3 and BT-549 cells. Cells (5 × 10⁶ per mouse, n = 5 for each group) were diluted in 200 ul PBS + 200 ul Matrigel (BD Biosciences) and subcutaneously injected into immunodeficient female mice. Third, the in vivo lung metastasis model was established by injecting with BT-549, BT-549LMF3, FTO stable BT-549LMF3, sh-METTL3 BT-549LMF3, and sh-KRT7 BT-549LMF3 stable cells (1 × 10⁶ per mouse, n = 5 for each group).

Breast cancer [ICD-11: 2C60]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	Specifically, increased METTL3 methylated KRT7-AS at A877 to increase the stability of a KRT7-AS/Keratin, type II cytoskeletal 7 (KRT7) mRNA duplex via IGF2BP1/HuR complexes. m6A promotes breast cancer lung metastasis by increasing the stability of a KRT7-AS/KRT7 mRNA duplex and translation of KRT7.
Responsed Disease	Breast cancer [ICD-11: 2C60]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Cell Process	Lung Metastasis
In-vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens	CVCL_0062
In-vitro Model	BT-549	Invasive breast carcinoma	Homo sapiens	CVCL_1092
In-vivo Model	First, subcutaneous transplanted model was used to evaluate the growth of BT-549LMF3 and BT-549 cells. Cells (5 × 10⁶ per mouse, n = 5 for each group) were diluted in 200 ul PBS + 200 ul Matrigel (BD Biosciences) and subcutaneously injected into immunodeficient female mice. Second, subcutaneous transplanted model was used to evaluate the metastasis potential of BT-549LMF3 and BT-549 cells. Cells (5 × 10⁶ per mouse, n = 5 for each group) were diluted in 200 ul PBS + 200 ul Matrigel (BD Biosciences) and subcutaneously injected into immunodeficient female mice. Third, the in vivo lung metastasis model was established by injecting with BT-549, BT-549LMF3, FTO stable BT-549LMF3, sh-METTL3 BT-549LMF3, and sh-KRT7 BT-549LMF3 stable cells (1 × 10⁶ per mouse, n = 5 for each group).

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00769)

Keratin, type II cytoskeletal 7 (KRT7)

2'-O-Methylation (2'-O-Me)

In total 2 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000051		Click to Show/Hide the Full List
mod site	chr12:52241616-52241617:+		[2]
Sequence	ATGCAGCCGGGCTGAGGCTGAAGCCTGGTACCAGACCAAGG
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000548088.1; ENST00000638501.1; ENST00000331817.6; ENST00000552183.1; ENST00000551130.1; ENST00000546856.5
External Link	RMBase: Nm_site_1337
mod ID: 2OMSITE000050		Click to Show/Hide the Full List
mod site	chr12:52235326-52235327:+		[2]
Sequence	GGGCCGCCTGGAGGCGGAGCTGCGGAGCATGCAGGATGTGG
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000547613.1; ENST00000331817.6
External Link	RMBase: Nm_site_1336

5-methylcytidine (m5C)

In total 19 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000003		Click to Show/Hide the Full List
mod site	chr12:52233235-52233236:+		[3]
Sequence	TAAAAGGCGCGGAGTGTCCCCGAGGTCAGCGAGTGCGCGCT
Cell/Tissue List	HeLa
Seq Type List	m5C-RIP-seq; Bisulfite-seq
Transcript ID List	ENST00000546666.1
External Link	RMBase: m5C_site_10079
mod ID: M5CSITE000004		Click to Show/Hide the Full List
mod site	chr12:52241464-52241465:+		[3]
Sequence	TCCTGATGTCCCGTCTGGTCCCTACAGGAGTTGACAGAGCT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000331817.6; ENST00000548088.1; ENST00000546856.5; ENST00000547613.1; ENST00000638501.1
External Link	RMBase: m5C_site_10080
mod ID: M5CSITE000005		Click to Show/Hide the Full List
mod site	chr12:52241465-52241466:+		[3]
Sequence	CCTGATGTCCCGTCTGGTCCCTACAGGAGTTGACAGAGCTG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000547613.1; ENST00000548088.1; ENST00000546856.5; ENST00000331817.6; ENST00000638501.1
External Link	RMBase: m5C_site_10081
mod ID: M5CSITE000006		Click to Show/Hide the Full List
mod site	chr12:52241468-52241469:+		[3]
Sequence	GATGTCCCGTCTGGTCCCTACAGGAGTTGACAGAGCTGCAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000546856.5; ENST00000547613.1; ENST00000331817.6; ENST00000548088.1; ENST00000638501.1
External Link	RMBase: m5C_site_10082
mod ID: M5CSITE000007		Click to Show/Hide the Full List
mod site	chr12:52241593-52241594:+
Sequence	GCGCAGTATGAGGAGATGGCCAAATGCAGCCGGGCTGAGGC
Cell/Tissue List	testis; HeLa
Seq Type List	Bisulfite-seq; m5C-RIP-seq
Transcript ID List	ENST00000638501.1; ENST00000552183.1; ENST00000546856.5; ENST00000331817.6; ENST00000548088.1; ENST00000551130.1
External Link	RMBase: m5C_site_10084
mod ID: M5CSITE000008		Click to Show/Hide the Full List
mod site	chr12:52243055-52243056:+
Sequence	GGGAAGCATGGGGACGACCTCCGGAATACCCGGAATGAGAT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000331817.6; ENST00000638501.1; ENST00000551130.1; ENST00000552183.1; ENST00000546856.5
External Link	RMBase: m5C_site_10085
mod ID: M5CSITE000009		Click to Show/Hide the Full List
mod site	chr12:52243056-52243057:+
Sequence	GGAAGCATGGGGACGACCTCCGGAATACCCGGAATGAGATT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000551130.1; ENST00000546856.5; ENST00000638501.1; ENST00000331817.6; ENST00000552183.1
External Link	RMBase: m5C_site_10086
mod ID: M5CSITE000010		Click to Show/Hide the Full List
mod site	chr12:52243088-52243089:+
Sequence	AATGAGATTTCAGAGATGAACCGGGCCATCCAGAGGCTGCA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000552183.1; ENST00000551130.1; ENST00000546856.5; ENST00000638501.1; ENST00000549127.5; ENST00000331817.6
External Link	RMBase: m5C_site_10087
mod ID: M5CSITE000011		Click to Show/Hide the Full List
mod site	chr12:52243124-52243125:+
Sequence	CTGCAGGCTGAGATCGACAACATCAAGAACCAGGTGGGACA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000546856.5; ENST00000552183.1; ENST00000551130.1; ENST00000638501.1; ENST00000331817.6; ENST00000549127.5
External Link	RMBase: m5C_site_10088
mod ID: M5CSITE000012		Click to Show/Hide the Full List
mod site	chr12:52243127-52243128:+
Sequence	CAGGCTGAGATCGACAACATCAAGAACCAGGTGGGACAAGT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000551130.1; ENST00000552183.1; ENST00000331817.6; ENST00000549127.5; ENST00000546856.5; ENST00000638501.1
External Link	RMBase: m5C_site_10089
mod ID: M5CSITE000013		Click to Show/Hide the Full List
mod site	chr12:52243133-52243134:+
Sequence	GAGATCGACAACATCAAGAACCAGGTGGGACAAGTCCTCCT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000331817.6; ENST00000638501.1; ENST00000549127.5; ENST00000552183.1; ENST00000546856.5; ENST00000551130.1
External Link	RMBase: m5C_site_10090
mod ID: M5CSITE000014		Click to Show/Hide the Full List
mod site	chr12:52243134-52243135:+
Sequence	AGATCGACAACATCAAGAACCAGGTGGGACAAGTCCTCCTG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000551130.1; ENST00000638501.1; ENST00000331817.6; ENST00000552183.1; ENST00000549127.5; ENST00000546856.5
External Link	RMBase: m5C_site_10091
mod ID: M5CSITE000015		Click to Show/Hide the Full List
mod site	chr12:52246395-52246396:+		[3]
Sequence	AAACATCCACAGAGGAAACCCCCAGAGACCAGTAACTTACA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000331817.6; ENST00000548657.5; ENST00000549127.5; ENST00000552322.5
External Link	RMBase: m5C_site_10092
mod ID: M5CSITE000016		Click to Show/Hide the Full List
mod site	chr12:52247042-52247043:+		[4]
Sequence	ACTCTGAGAGGATATGGTTCCCCCAACCCTGGGGGGATATG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000552322.5; ENST00000549127.5; ENST00000331817.6; ENST00000548657.5
External Link	RMBase: m5C_site_10093
mod ID: M5CSITE000017		Click to Show/Hide the Full List
mod site	chr12:52247043-52247044:+		[4]
Sequence	CTCTGAGAGGATATGGTTCCCCCAACCCTGGGGGGATATGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000331817.6; ENST00000548657.5; ENST00000552322.5; ENST00000549127.5
External Link	RMBase: m5C_site_10094
mod ID: M5CSITE000018		Click to Show/Hide the Full List
mod site	chr12:52247044-52247045:+		[4]
Sequence	TCTGAGAGGATATGGTTCCCCCAACCCTGGGGGGATATGGA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000331817.6; ENST00000549127.5; ENST00000548657.5; ENST00000552322.5
External Link	RMBase: m5C_site_10095
mod ID: M5CSITE000019		Click to Show/Hide the Full List
mod site	chr12:52247045-52247046:+		[4]
Sequence	CTGAGAGGATATGGTTCCCCCAACCCTGGGGGGATATGGAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000331817.6; ENST00000552322.5; ENST00000548657.5; ENST00000549127.5
External Link	RMBase: m5C_site_10096
mod ID: M5CSITE000020		Click to Show/Hide the Full List
mod site	chr12:52247230-52247231:+		[3]
Sequence	CTTGGACATTCAGGCCTCTTCCGTCTGAGTTCCTTAGGCAT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000331817.6; ENST00000548657.5; ENST00000552322.5; ENST00000549127.5
External Link	RMBase: m5C_site_10097
mod ID: M5CSITE000021		Click to Show/Hide the Full List
mod site	chr12:52250547-52250548:+		[3]
Sequence	TGCTCACCGCCACGTTCCCGCTGCAGGGGGCACTGCAGACG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000548657.5; ENST00000553310.6
External Link	RMBase: m5C_site_10100

N6-methyladenosine (m6A)

In total 47 m6A sequence/site(s) in this target gene
mod ID: M6ASITE012476		Click to Show/Hide the Full List
mod site	chr12:52232708-52232709:+		[5]
Sequence	GAAGGAACGCAGCCAGGGAAACTAGCTGGGCCAGGAGGGGT
Motif Score	2.627720238
Cell/Tissue List	HeLa; A549; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000552400.1; ENST00000546666.1
External Link	RMBase: m6A_site_189080
mod ID: M6ASITE012477		Click to Show/Hide the Full List
mod site	chr12:52232732-52232733:+		[5]
Sequence	GCTGGGCCAGGAGGGGTCAGACCCCTGAACAAGTGAGCTGA
Motif Score	2.876744048
Cell/Tissue List	HeLa; A549; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000552400.1; ENST00000546666.1
External Link	RMBase: m6A_site_189081
mod ID: M6ASITE012478		Click to Show/Hide the Full List
mod site	chr12:52232740-52232741:+		[5]
Sequence	AGGAGGGGTCAGACCCCTGAACAAGTGAGCTGATCTCTCAA
Motif Score	2.951386905
Cell/Tissue List	HeLa; A549; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000546666.1; ENST00000552400.1
External Link	RMBase: m6A_site_189082
mod ID: M6ASITE012479		Click to Show/Hide the Full List
mod site	chr12:52233064-52233065:+		[5]
Sequence	GGCGCTCCTGCCTACTCCGGACCATCCCTGCTTGGACTGAA
Motif Score	3.622404762
Cell/Tissue List	HeLa; A549; HepG2; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000546666.1; ENST00000552400.1
External Link	RMBase: m6A_site_189083
mod ID: M6ASITE012480		Click to Show/Hide the Full List
mod site	chr12:52233079-52233080:+		[5]
Sequence	TCCGGACCATCCCTGCTTGGACTGAAAGCCTGGGCTTCGGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; A549; HepG2; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000546666.1; ENST00000552400.1
External Link	RMBase: m6A_site_189084
mod ID: M6ASITE012481		Click to Show/Hide the Full List
mod site	chr12:52233584-52233585:+		[5]
Sequence	AGGAGAGCGAGCAGATCAAGACCCTCAACAACAAGTTTGCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000331817.6
External Link	RMBase: m6A_site_189085
mod ID: M6ASITE012482		Click to Show/Hide the Full List
mod site	chr12:52235176-52235177:+		[5]
Sequence	GCGGTTTCTGGAGCAGCAGAACAAGCTGCTGGAGACCAAGT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000331817.6; ENST00000547613.1
External Link	RMBase: m6A_site_189086
mod ID: M6ASITE012483		Click to Show/Hide the Full List
mod site	chr12:52235190-52235191:+		[5]
Sequence	AGCAGAACAAGCTGCTGGAGACCAAGTGGACGCTGCTGCAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000331817.6; ENST00000547613.1
External Link	RMBase: m6A_site_189087
mod ID: M6ASITE012484		Click to Show/Hide the Full List
mod site	chr12:52235245-52235246:+		[5]
Sequence	CAAGAGCAGCCGCCTCCCAGACATCTTTGAGGCCCAGATTG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000547613.1; ENST00000331817.6
External Link	RMBase: m6A_site_189088
mod ID: M6ASITE012485		Click to Show/Hide the Full List
mod site	chr12:52235353-52235354:+		[5]
Sequence	CATGCAGGATGTGGTGGAGGACTTCAAGAATAAGTAATGCC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000547613.1; ENST00000331817.6
External Link	RMBase: m6A_site_189089
mod ID: M6ASITE012487		Click to Show/Hide the Full List
mod site	chr12:52237582-52237583:+		[5]
Sequence	GAAGAAGGTGAGTGGGAAAGACAGGCTCGAGGAGGGTTGTC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; A549; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000331817.6; ENST00000547613.1
External Link	RMBase: m6A_site_189090
mod ID: M6ASITE012488		Click to Show/Hide the Full List
mod site	chr12:52237608-52237609:+		[5]
Sequence	TCGAGGAGGGTTGTCTGAAAACATGGGACAAAGGACCACAG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; A549; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000331817.6; ENST00000547613.1
External Link	RMBase: m6A_site_189091
mod ID: M6ASITE012489		Click to Show/Hide the Full List
mod site	chr12:52237615-52237616:+		[5]
Sequence	GGGTTGTCTGAAAACATGGGACAAAGGACCACAGGATCCTC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000331817.6; ENST00000547613.1
External Link	RMBase: m6A_site_189092
mod ID: M6ASITE012490		Click to Show/Hide the Full List
mod site	chr12:52237622-52237623:+		[5]
Sequence	CTGAAAACATGGGACAAAGGACCACAGGATCCTCTCACCTG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000331817.6; ENST00000547613.1
External Link	RMBase: m6A_site_189093
mod ID: M6ASITE012491		Click to Show/Hide the Full List
mod site	chr12:52237657-52237658:+		[5]
Sequence	CACCTGAGCAGCCCATGGGGACCTCTGGCCAAGGCCTGCCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000547613.1; ENST00000331817.6
External Link	RMBase: m6A_site_189094
mod ID: M6ASITE012492		Click to Show/Hide the Full List
mod site	chr12:52238760-52238761:+		[6]
Sequence	ATGAGATCAACTTCCTCAGGACCCTCAATGAGACGGTGAGG
Motif Score	3.622404762
Cell/Tissue List	HepG2; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000548088.1; ENST00000638501.1; ENST00000331817.6; ENST00000546856.5; ENST00000547613.1
External Link	RMBase: m6A_site_189095
mod ID: M6ASITE012493		Click to Show/Hide the Full List
mod site	chr12:52241526-52241527:+		[6]
Sequence	ATCTGTGGTGCTGTCCATGGACAACAGTCGCTCCCTGGACC
Motif Score	3.643047619
Cell/Tissue List	HepG2; A549; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000331817.6; ENST00000638501.1; ENST00000548088.1; ENST00000546856.5
External Link	RMBase: m6A_site_189096
mod ID: M6ASITE012494		Click to Show/Hide the Full List
mod site	chr12:52241544-52241545:+		[7]
Sequence	GGACAACAGTCGCTCCCTGGACCTGGACGGCATCATCGCTG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000638501.1; ENST00000546856.5; ENST00000548088.1; ENST00000552183.1; ENST00000331817.6; ENST00000551130.1
External Link	RMBase: m6A_site_189097
mod ID: M6ASITE012495		Click to Show/Hide the Full List
mod site	chr12:52241630-52241631:+		[7]
Sequence	AGGCTGAAGCCTGGTACCAGACCAAGGTGTGAGGCCACCAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000548088.1; ENST00000546856.5; ENST00000552183.1; ENST00000331817.6; ENST00000551130.1; ENST00000638501.1
External Link	RMBase: m6A_site_189098
mod ID: M6ASITE012496		Click to Show/Hide the Full List
mod site	chr12:52243017-52243018:+		[5]
Sequence	TATGGCCCCTCCAGTTTGAGACCCTCCAGGCCCAGGCTGGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000551130.1; ENST00000638501.1; ENST00000552183.1; ENST00000331817.6; ENST00000546856.5
External Link	RMBase: m6A_site_189099
mod ID: M6ASITE012498		Click to Show/Hide the Full List
mod site	chr12:52243087-52243088:+		[5]
Sequence	GAATGAGATTTCAGAGATGAACCGGGCCATCCAGAGGCTGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; A549; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000638501.1; ENST00000551130.1; ENST00000552183.1; ENST00000549127.5; ENST00000331817.6; ENST00000546856.5
External Link	RMBase: m6A_site_189100
mod ID: M6ASITE012499		Click to Show/Hide the Full List
mod site	chr12:52243132-52243133:+		[5]
Sequence	TGAGATCGACAACATCAAGAACCAGGTGGGACAAGTCCTCC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; A549; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000638501.1; ENST00000552183.1; ENST00000331817.6; ENST00000546856.5; ENST00000549127.5; ENST00000551130.1
External Link	RMBase: m6A_site_189101
mod ID: M6ASITE012500		Click to Show/Hide the Full List
mod site	chr12:52243142-52243143:+		[5]
Sequence	AACATCAAGAACCAGGTGGGACAAGTCCTCCTGGCTTCCCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000552183.1; ENST00000638501.1; ENST00000331817.6; ENST00000546856.5; ENST00000551130.1; ENST00000549127.5
External Link	RMBase: m6A_site_189102
mod ID: M6ASITE012501		Click to Show/Hide the Full List
mod site	chr12:52243202-52243203:+		[5]
Sequence	GGGTGGCCAGCTGAGGCCAAACTCAGGATGTGGAGCAGGAG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; A549; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000638501.1; ENST00000551130.1; ENST00000552183.1; ENST00000331817.6; ENST00000546856.5; ENST00000549127.5
External Link	RMBase: m6A_site_189103
mod ID: M6ASITE012502		Click to Show/Hide the Full List
mod site	chr12:52243262-52243263:+		[5]
Sequence	AGCTGGTGCCACTGTCTCAGACCCCCTTGTGAGATCTCCAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000638501.1; ENST00000551130.1; ENST00000331817.6; ENST00000552183.1; ENST00000549127.5; ENST00000546856.5
External Link	RMBase: m6A_site_189104
mod ID: M6ASITE012503		Click to Show/Hide the Full List
mod site	chr12:52243362-52243363:+		[5]
Sequence	CACAGAGCCTGTGGAGGGAGACTCAGGCTGGCTGGCCAGAA
Motif Score	3.319380952
Cell/Tissue List	HeLa; A549; HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000551130.1; ENST00000546856.5; ENST00000549127.5; ENST00000638501.1; ENST00000331817.6; ENST00000552183.1
External Link	RMBase: m6A_site_189105
mod ID: M6ASITE012504		Click to Show/Hide the Full List
mod site	chr12:52243482-52243483:+		[5]
Sequence	GCTCATCATTCATTGCAGGGACAGAGGACAGCAGAAGACCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; A549; HepG2; hESCs; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000638501.1; ENST00000331817.6; ENST00000552183.1; ENST00000549127.5; ENST00000546856.5
External Link	RMBase: m6A_site_189106
mod ID: M6ASITE012505		Click to Show/Hide the Full List
mod site	chr12:52243489-52243490:+		[5]
Sequence	ATTCATTGCAGGGACAGAGGACAGCAGAAGACCTTATAATG
Motif Score	3.643047619
Cell/Tissue List	HeLa; A549; HepG2; hESCs; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	rmsk_3791109; ENST00000546856.5; ENST00000331817.6; ENST00000638501.1; ENST00000552183.1; ENST00000549127.5
External Link	RMBase: m6A_site_189107
mod ID: M6ASITE012506		Click to Show/Hide the Full List
mod site	chr12:52243499-52243500:+		[5]
Sequence	GGGACAGAGGACAGCAGAAGACCTTATAATGACTCACATGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; A549; HepG2; hESCs; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000549127.5; ENST00000546856.5; ENST00000552183.1; ENST00000331817.6; ENST00000638501.1; rmsk_3791109
External Link	RMBase: m6A_site_189108
mod ID: M6ASITE012507		Click to Show/Hide the Full List
mod site	chr12:52244566-52244567:+		[5]
Sequence	TGTCTCTGGCAGAGAGGCAGACTGCCTCCACTGAGGGAAGA
Motif Score	3.319380952
Cell/Tissue List	HeLa; A549; HepG2; U2OS; GM12878; MT4; CD4T; GSC-11; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000331817.6; ENST00000549127.5; ENST00000552183.1; ENST00000552322.5; ENST00000638501.1
External Link	RMBase: m6A_site_189109
mod ID: M6ASITE012510		Click to Show/Hide the Full List
mod site	chr12:52245371-52245372:+		[5]
Sequence	ATGGGCAGGCAGGAAGGCAGACTGGTGAGCCCCAGCTTACA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; U2OS; MT4; A549; CD4T; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000552322.5; ENST00000638501.1; ENST00000331817.6; ENST00000549127.5
External Link	RMBase: m6A_site_189111
mod ID: M6ASITE012511		Click to Show/Hide the Full List
mod site	chr12:52245557-52245558:+		[5]
Sequence	CAGCTGCGTGAGTACCAGGAACTCATGAGCGTGAAGCTGGC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; U2OS; MT4; A549; CD4T; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548657.5; ENST00000549127.5; ENST00000552322.5; ENST00000331817.6
External Link	RMBase: m6A_site_189112
mod ID: M6ASITE012512		Click to Show/Hide the Full List
mod site	chr12:52245583-52245584:+		[5]
Sequence	GAGCGTGAAGCTGGCCCTGGACATCGAGATCGCCACCTACC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; U2OS; MT4; A549; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000552322.5; ENST00000549127.5; ENST00000548657.5; ENST00000331817.6
External Link	RMBase: m6A_site_189113
mod ID: M6ASITE012518		Click to Show/Hide the Full List
mod site	chr12:52247766-52247767:+		[5]
Sequence	AAAGTATCAATAGGCCACAGACACCTTTAGGATTTTATGAT
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000331817.6; ENST00000548657.5; ENST00000552322.5; ENST00000550153.1; ENST00000549127.5
External Link	RMBase: m6A_site_189119
mod ID: M6ASITE012520		Click to Show/Hide the Full List
mod site	chr12:52248652-52248653:+		[6]
Sequence	TTGGGCTGACCCTCGGGGGAACCATGGGCAGCAATGCCCTG
Motif Score	2.930744048
Cell/Tissue List	HepG2; HeLa; MT4; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000549127.5; ENST00000549638.1; ENST00000548657.5; ENST00000552322.5; ENST00000331817.6; ENST00000550153.1
External Link	RMBase: m6A_site_189120
mod ID: M6ASITE012521		Click to Show/Hide the Full List
mod site	chr12:52248724-52248725:+		[6]
Sequence	TGAAGGCTTATTCCATCCGGACCGCATCCGCCAGTCGCAGG
Motif Score	3.622404762
Cell/Tissue List	HepG2; HeLa; MT4; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000550153.1; ENST00000548657.5; ENST00000331817.6; ENST00000552322.5; ENST00000549638.1
External Link	RMBase: m6A_site_189121
mod ID: M6ASITE012522		Click to Show/Hide the Full List
mod site	chr12:52248845-52248846:+		[5]
Sequence	CTCCCATGCCTGGTCCCAAGACAGTGAGACAGTCTGGAAAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; MT4; A549; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000550153.1; ENST00000548657.5; ENST00000331817.6; ENST00000549638.1; ENST00000552322.5
External Link	RMBase: m6A_site_189122
mod ID: M6ASITE012523		Click to Show/Hide the Full List
mod site	chr12:52248853-52248854:+		[5]
Sequence	CCTGGTCCCAAGACAGTGAGACAGTCTGGAAAGTGATGTCA
Motif Score	2.897386905
Cell/Tissue List	HeLa; MT4; A549; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000331817.6; ENST00000548657.5; ENST00000552322.5; ENST00000550153.1; ENST00000549638.1
External Link	RMBase: m6A_site_189123
mod ID: M6ASITE012524		Click to Show/Hide the Full List
mod site	chr12:52251785-52251786:+		[5]
Sequence	TTTCCTTTTAGAGTCTGCAAACTACGGCCACATGCAGGCTT
Motif Score	2.627720238
Cell/Tissue List	HeLa; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000548657.5; rmsk_3791123; ENST00000553310.6
External Link	RMBase: m6A_site_189125
mod ID: M6ASITE012525		Click to Show/Hide the Full List
mod site	chr12:52251833-52251834:+		[8]
Sequence	GTCAATCAAGTTTTCTTGGAACCCAGTCATACCGCTTCCTT
Motif Score	2.930744048
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	rmsk_3791123; ENST00000548657.5; ENST00000553310.6
External Link	RMBase: m6A_site_189126
mod ID: M6ASITE012526		Click to Show/Hide the Full List
mod site	chr12:52251891-52251892:+		[9]
Sequence	TGTGGCTGCTTTACATGACAACGGAGTGGAGCAGTTGAGGC
Motif Score	2.147845238
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000553310.6; ENST00000548657.5; rmsk_3791123
External Link	RMBase: m6A_site_189127
mod ID: M6ASITE012527		Click to Show/Hide the Full List
mod site	chr12:52251916-52251917:+		[5]
Sequence	GTGGAGCAGTTGAGGCAGAGACTACATGGCCCACGAGCCTA
Motif Score	3.319380952
Cell/Tissue List	HeLa; A549; MT4; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548657.5; ENST00000553310.6; rmsk_3791123
External Link	RMBase: m6A_site_189128
mod ID: M6ASITE012528		Click to Show/Hide the Full List
mod site	chr12:52251983-52251984:+		[5]
Sequence	AAAAAGTTTGCCTGCCCAGAACCCCAAGCTGTTATTTCAGG
Motif Score	2.930744048
Cell/Tissue List	HeLa; A549; HepG2; GM12878; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548657.5; ENST00000553310.6
External Link	RMBase: m6A_site_189129
mod ID: M6ASITE012530		Click to Show/Hide the Full List
mod site	chr12:52252004-52252005:+		[5]
Sequence	CCCCAAGCTGTTATTTCAGGACCCACAAAATGGATTACTTA
Motif Score	3.622404762
Cell/Tissue List	HeLa; A549; HepG2; GM12878; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548657.5; ENST00000553310.6
External Link	RMBase: m6A_site_189130
mod ID: M6ASITE012531		Click to Show/Hide the Full List
mod site	chr12:52252028-52252029:+		[5]
Sequence	ACAAAATGGATTACTTACAGACATTTACAGCACCAACGCCC
Motif Score	2.897386905
Cell/Tissue List	HeLa; A549; HepG2; GM12878; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000548657.5; ENST00000553310.6
External Link	RMBase: m6A_site_189131
mod ID: M6ASITE012532		Click to Show/Hide the Full List
mod site	chr12:52252078-52252079:+		[5]
Sequence	CTTATAGGGAAAGCAAAGAGACAGAAATTAGTTGTGGGGAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; A549; HepG2; GM12878; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548657.5; ENST00000553310.6
External Link	RMBase: m6A_site_189132
mod ID: M6ASITE012533		Click to Show/Hide the Full List
mod site	chr12:52252180-52252181:+		[10]
Sequence	TCCAAGTAAATAATATGCAGACATGCTCCTGGGTGTTGAAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; A549; GM12878; MSC; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000548657.5; ENST00000553310.6
External Link	RMBase: m6A_site_189133

Ref 1	N(6) -Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis. Cancer Res. 2021 Jun 1;81(11):2847-2860. doi: 10.1158/0008-5472.CAN-20-3779. Epub 2021 Apr 1.
Ref 2	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.
Ref 3	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 4	Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6784-6789. doi: 10.1073/pnas.1817334116. Epub 2019 Mar 14.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 7	RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nat Commun. 2019 May 6;10(1):2065. doi: 10.1038/s41467-019-09865-9.
Ref 8	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 9	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 10	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

Visitor Map