m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00766)

Target Name	L-glutamine amidohydrolase (GLS2)
Synonyms	GA; Glutaminase liver isoform; mitochondrial; GLS; EC 3.5.1.2 ; L-glutaminase ; L-glutamine amidohydrolase Click to Show/Hide
Gene Name	GLS2
Chromosomal Location	12q13.3
Family	Glutaminase family
Function	Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. Click to Show/Hide
Gene ID	27165
Uniprot ID	GLSL_HUMAN
HGNC ID	HGNC:29570
KEGG ID	hsa:27165

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

GLS2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RIP-seq result supporting the interaction between GLS2 and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 5.89E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	L-glutamine amidohydrolase (GLS2) as a downstream target of METTL3. These findings uncover METTL3/GLS2 signaling as a potential therapeutic target in antimetastatic strategies against esophageal Squamous Cell Carcinoma(ESCC).
Target Regulation	Up regulation
Responsed Disease	Esophageal squamous cell carcinoma		ICD-11: 2B70.1	Disease Info
Cell Process	Cell migration
Cell Process	Cell invasion
In-vitro Model	HEEC cell line (Normal esophageal epithelial cell line)
	TE-1	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_1759
	TE-13	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_4463
	Eca-109	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_6898
	EC/CUHK1	Esophageal carcinoma	Homo sapiens	CVCL_RY08

Esophageal cancer [ICD-11: 2B70]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	L-glutamine amidohydrolase (GLS2) as a downstream target of METTL3. These findings uncover METTL3/GLS2 signaling as a potential therapeutic target in antimetastatic strategies against esophageal Squamous Cell Carcinoma(ESCC).
Responsed Disease	Esophageal squamous cell carcinoma [ICD-11: 2B70.1]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Cell Process	Cell migration
Cell Process	Cell invasion
In-vitro Model	HEEC cell line (Normal esophageal epithelial cell line)
	TE-1	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_1759
	TE-13	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_4463
	Eca-109	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_6898
	EC/CUHK1	Esophageal carcinoma	Homo sapiens	CVCL_RY08

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Histone modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03371		Crosstalk Info
Regulated Target	Histone H3 lysine 18 lactylation (H3K18la)
Crosstalk relationship	Histone modification → m6A
Disease	Esophageal Squamous Cell Carcinoma	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00766)

L-glutamine amidohydrolase (GLS2)

Adenosine-to-Inosine editing (A-to-I)

In total 21 m6A sequence/site(s) in this target gene
mod ID: A2ISITE005608		Click to Show/Hide the Full List
mod site	chr12:56476316-56476317:-		[3]
Sequence	GGAAGTGGGATGGCCCAGCAAGCTGGCTCATGCCTGTAATC
Transcript ID List	ENST00000486433.5; ENST00000610413.4; ENST00000461077.1; ENST00000494474.5; ENST00000623608.3; ENST00000539272.5; ENST00000424141.6; ENST00000476991.5; ENST00000496006.5; ENST00000494345.5; ENST00000479952.5; ENST00000311966.9; ENST00000486896.5; ENST00000648304.1
External Link	RMBase: RNA-editing_site_29137
mod ID: A2ISITE005609		Click to Show/Hide the Full List
mod site	chr12:56477395-56477396:-		[3]
Sequence	CCTAGAGCTTTCTGACCCTTAGAGAAGTGAGCAGGTCCTGA
Transcript ID List	ENST00000494474.5; ENST00000494345.5; ENST00000311966.9; ENST00000623608.3; ENST00000424141.6; ENST00000648304.1; ENST00000486896.5; ENST00000479952.5; ENST00000461077.1; ENST00000610413.4; ENST00000539272.5; ENST00000496006.5; ENST00000486433.5
External Link	RMBase: RNA-editing_site_29138
mod ID: A2ISITE005610		Click to Show/Hide the Full List
mod site	chr12:56478742-56478743:-		[4]
Sequence	ACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCA
Transcript ID List	ENST00000494345.5; ENST00000311966.9; ENST00000539272.5; ENST00000424141.6; ENST00000483347.1; ENST00000494474.5; ENST00000461077.1; ENST00000623608.3; ENST00000479952.5; ENST00000648304.1; ENST00000486896.5; ENST00000610413.4; ENST00000486433.5
External Link	RMBase: RNA-editing_site_29139
mod ID: A2ISITE005611		Click to Show/Hide the Full List
mod site	chr12:56481434-56481435:-		[3]
Sequence	GGCAGGCGGATCACGAGGTAAGGCGTTCGAGACCAGCCTGA
Transcript ID List	ENST00000424141.6; rmsk_3799273; ENST00000483347.1; ENST00000479952.5; ENST00000471282.5; ENST00000311966.9; ENST00000494474.5; ENST00000494345.5; ENST00000486896.5; ENST00000610413.4; ENST00000491880.1; ENST00000648304.1; ENST00000623608.3; ENST00000486433.5; ENST00000461077.1
External Link	RMBase: RNA-editing_site_29140
mod ID: A2ISITE005612		Click to Show/Hide the Full List
mod site	chr12:56485480-56485481:-		[5]
Sequence	CTTGAGCTCAGGAGTTCGAAACCAGCTTGGGCAGCATGGCA
Transcript ID List	ENST00000494474.5; ENST00000483347.1; ENST00000486896.5; ENST00000491880.1; ENST00000623608.3; ENST00000648304.1; ENST00000479952.5; ENST00000494345.5; ENST00000311966.9; ENST00000486433.5; ENST00000461077.1; rmsk_3799293; ENST00000610413.4; ENST00000471282.5; ENST00000424141.6
External Link	RMBase: RNA-editing_site_29141
mod ID: A2ISITE005613		Click to Show/Hide the Full List
mod site	chr12:56485482-56485483:-		[5]
Sequence	CACTTGAGCTCAGGAGTTCGAAACCAGCTTGGGCAGCATGG
Transcript ID List	ENST00000648304.1; ENST00000623608.3; ENST00000424141.6; rmsk_3799293; ENST00000491880.1; ENST00000486433.5; ENST00000494345.5; ENST00000461077.1; ENST00000471282.5; ENST00000486896.5; ENST00000479952.5; ENST00000494474.5; ENST00000610413.4; ENST00000311966.9; ENST00000483347.1
External Link	RMBase: RNA-editing_site_29142
mod ID: A2ISITE005614		Click to Show/Hide the Full List
mod site	chr12:56485515-56485516:-		[5]
Sequence	TCCCAGCACTGTGGGTGGCCAAGGCAGGGGGATCACTTGAG
Transcript ID List	ENST00000610413.4; ENST00000483347.1; ENST00000623608.3; ENST00000479952.5; ENST00000486433.5; ENST00000486896.5; ENST00000494474.5; ENST00000491880.1; ENST00000648304.1; rmsk_3799293; ENST00000461077.1; ENST00000424141.6; ENST00000471282.5; ENST00000494345.5; ENST00000311966.9
External Link	RMBase: RNA-editing_site_29143
mod ID: A2ISITE005615		Click to Show/Hide the Full List
mod site	chr12:56485531-56485532:-		[5]
Sequence	TGGCTCACACCTGTAATCCCAGCACTGTGGGTGGCCAAGGC
Transcript ID List	ENST00000610413.4; ENST00000424141.6; ENST00000648304.1; ENST00000494345.5; rmsk_3799293; ENST00000479952.5; ENST00000471282.5; ENST00000461077.1; ENST00000486433.5; ENST00000483347.1; ENST00000491880.1; ENST00000311966.9; ENST00000486896.5; ENST00000623608.3; ENST00000494474.5
External Link	RMBase: RNA-editing_site_29144
mod ID: A2ISITE005616		Click to Show/Hide the Full List
mod site	chr12:56485820-56485821:-		[5]
Sequence	TCAAACTCATGACCTCAGATAATCCACCTGCCTCGGCCTCC
Transcript ID List	ENST00000311966.9; ENST00000483347.1; ENST00000479952.5; ENST00000424141.6; ENST00000494345.5; ENST00000648304.1; ENST00000491880.1; ENST00000623608.3; ENST00000461077.1; ENST00000486433.5; ENST00000610413.4; ENST00000486896.5; ENST00000494474.5; ENST00000471282.5
External Link	RMBase: RNA-editing_site_29145
mod ID: A2ISITE005617		Click to Show/Hide the Full List
mod site	chr12:56485824-56485825:-		[5]
Sequence	GGTCTCAAACTCATGACCTCAGATAATCCACCTGCCTCGGC
Transcript ID List	ENST00000461077.1; ENST00000610413.4; ENST00000483347.1; ENST00000494345.5; ENST00000486433.5; ENST00000491880.1; ENST00000486896.5; ENST00000471282.5; ENST00000479952.5; ENST00000648304.1; ENST00000311966.9; ENST00000424141.6; ENST00000494474.5; ENST00000623608.3
External Link	RMBase: RNA-editing_site_29146
mod ID: A2ISITE005618		Click to Show/Hide the Full List
mod site	chr12:56485832-56485833:-		[5]
Sequence	GCCAGGCTGGTCTCAAACTCATGACCTCAGATAATCCACCT
Transcript ID List	ENST00000610413.4; ENST00000483347.1; ENST00000311966.9; ENST00000486433.5; ENST00000491880.1; ENST00000486896.5; ENST00000623608.3; ENST00000479952.5; ENST00000648304.1; ENST00000494345.5; ENST00000424141.6; ENST00000494474.5; ENST00000461077.1; ENST00000471282.5
External Link	RMBase: RNA-editing_site_29147
mod ID: A2ISITE005619		Click to Show/Hide the Full List
mod site	chr12:56485849-56485850:-		[5]
Sequence	GGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCATGA
Transcript ID List	ENST00000494474.5; ENST00000479952.5; ENST00000494345.5; ENST00000483347.1; ENST00000648304.1; ENST00000461077.1; ENST00000623608.3; ENST00000491880.1; ENST00000486896.5; ENST00000471282.5; ENST00000486433.5; ENST00000424141.6; ENST00000610413.4; ENST00000311966.9
External Link	RMBase: RNA-editing_site_29148
mod ID: A2ISITE005620		Click to Show/Hide the Full List
mod site	chr12:56485909-56485910:-		[5]
Sequence	AGCTGGGATTACAGGCACCCACCACTACGACTGGCTAATTT
Transcript ID List	ENST00000483347.1; ENST00000623608.3; ENST00000424141.6; ENST00000471282.5; ENST00000491880.1; ENST00000486896.5; ENST00000479952.5; ENST00000494345.5; ENST00000610413.4; ENST00000648304.1; ENST00000494474.5; ENST00000311966.9; ENST00000486433.5; ENST00000461077.1
External Link	RMBase: RNA-editing_site_29149
mod ID: A2ISITE005621		Click to Show/Hide the Full List
mod site	chr12:56485952-56485953:-		[5]
Sequence	CGCAATCTCGGCTCACTGCAACCTCTGCCTCAGCTTCCTGA
Transcript ID List	ENST00000486896.5; ENST00000311966.9; ENST00000483347.1; ENST00000610413.4; ENST00000424141.6; ENST00000494474.5; ENST00000461077.1; ENST00000486433.5; ENST00000494345.5; ENST00000491880.1; ENST00000479952.5; ENST00000623608.3; ENST00000648304.1; ENST00000471282.5
External Link	RMBase: RNA-editing_site_29150
mod ID: A2ISITE005622		Click to Show/Hide the Full List
mod site	chr12:56485968-56485969:-		[5]
Sequence	GGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTC
Transcript ID List	ENST00000648304.1; ENST00000424141.6; ENST00000311966.9; ENST00000471282.5; ENST00000486433.5; ENST00000483347.1; ENST00000461077.1; ENST00000486896.5; ENST00000491880.1; ENST00000479952.5; ENST00000623608.3; ENST00000494474.5; ENST00000494345.5; ENST00000610413.4
External Link	RMBase: RNA-editing_site_29151
mod ID: A2ISITE005623		Click to Show/Hide the Full List
mod site	chr12:56485977-56485978:-		[5]
Sequence	TGCCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCAC
Transcript ID List	ENST00000494345.5; ENST00000424141.6; ENST00000648304.1; ENST00000479952.5; ENST00000483347.1; ENST00000494474.5; ENST00000491880.1; ENST00000623608.3; ENST00000486433.5; ENST00000486896.5; ENST00000461077.1; ENST00000471282.5; ENST00000311966.9; ENST00000610413.4
External Link	RMBase: RNA-editing_site_29152
mod ID: A2ISITE005624		Click to Show/Hide the Full List
mod site	chr12:56485989-56485990:-		[5]
Sequence	ACAGAGTCTCTTTGCCGCCCAGGCTGGAGTGCAGTGGCGCA
Transcript ID List	ENST00000610413.4; ENST00000623608.3; ENST00000483347.1; ENST00000424141.6; ENST00000494474.5; ENST00000461077.1; ENST00000491880.1; ENST00000648304.1; ENST00000494345.5; ENST00000479952.5; ENST00000471282.5; ENST00000486896.5; ENST00000311966.9; ENST00000486433.5
External Link	RMBase: RNA-editing_site_29153
mod ID: A2ISITE005625		Click to Show/Hide the Full List
mod site	chr12:56486668-56486669:-		[5]
Sequence	TTTGTAGTTTTAGTAGAGACAGGGTTTCACCGTGTTGGCCC
Transcript ID List	ENST00000486896.5; ENST00000623608.3; ENST00000494345.5; ENST00000491880.1; ENST00000424141.6; ENST00000471282.5; ENST00000479952.5; ENST00000486433.5; ENST00000461077.1; ENST00000648304.1; ENST00000494474.5; ENST00000610413.4; ENST00000483347.1; ENST00000311966.9
External Link	RMBase: RNA-editing_site_29154
mod ID: A2ISITE005626		Click to Show/Hide the Full List
mod site	chr12:56486772-56486773:-		[5]
Sequence	CCACCTCCTGGGTTCAAGTAATTCTCCTGCCTCAGCCTCTC
Transcript ID List	ENST00000623608.3; ENST00000483347.1; ENST00000461077.1; ENST00000491880.1; ENST00000486433.5; ENST00000648304.1; ENST00000471282.5; ENST00000494345.5; ENST00000424141.6; ENST00000494474.5; ENST00000486896.5; ENST00000311966.9; ENST00000479952.5; ENST00000610413.4
External Link	RMBase: RNA-editing_site_29155
mod ID: A2ISITE005627		Click to Show/Hide the Full List
mod site	chr12:56486773-56486774:-		[5]
Sequence	TCCACCTCCTGGGTTCAAGTAATTCTCCTGCCTCAGCCTCT
Transcript ID List	ENST00000491880.1; ENST00000483347.1; ENST00000494345.5; ENST00000479952.5; ENST00000471282.5; ENST00000494474.5; ENST00000610413.4; ENST00000461077.1; ENST00000623608.3; ENST00000311966.9; ENST00000486433.5; ENST00000424141.6; ENST00000486896.5; ENST00000648304.1
External Link	RMBase: RNA-editing_site_29156
mod ID: A2ISITE005628		Click to Show/Hide the Full List
mod site	chr12:56487567-56487568:-		[5]
Sequence	GTATTTTAGGAGATGCGTGGATGTGGAACAGCCTCCTGCCT
Transcript ID List	ENST00000471282.5; ENST00000623608.3; ENST00000486896.5; ENST00000610413.4; ENST00000483347.1; ENST00000486433.5; ENST00000648304.1; ENST00000311966.9; ENST00000494474.5; ENST00000479952.5; ENST00000494345.5; ENST00000461077.1; ENST00000424141.6; ENST00000491880.1
External Link	RMBase: RNA-editing_site_29157

N6-methyladenosine (m6A)

In total 15 m6A sequence/site(s) in this target gene
mod ID: M6ASITE013477		Click to Show/Hide the Full List
mod site	chr12:56471032-56471033:-		[6]
Sequence	ATCTACTCCCCTTGGCCAGGACATGCTGCTGCTACTGCTAA
Motif Score	3.643047619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000311966.9; ENST00000424141.6; ENST00000610413.4; ENST00000648304.1; ENST00000539272.5; ENST00000390288.6; ENST00000486433.5; ENST00000479952.5; ENST00000623608.3
External Link	RMBase: m6A_site_193627
mod ID: M6ASITE013478		Click to Show/Hide the Full List
mod site	chr12:56471136-56471137:-		[7]
Sequence	AGAGATACTCTGGTGGAGGGACTCTAGCTACCATGCACATG
Motif Score	4.065041667
Cell/Tissue List	HEK293T; H1A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000610413.4; ENST00000390288.6; ENST00000311966.9; ENST00000648304.1; ENST00000486433.5; ENST00000424141.6; ENST00000479952.5; ENST00000623608.3; ENST00000539272.5
External Link	RMBase: m6A_site_193629
mod ID: M6ASITE013479		Click to Show/Hide the Full List
mod site	chr12:56471167-56471168:-		[7]
Sequence	CTCTTCCTCTCCCTGAAGAAACCATCATGAGAGAGATACTC
Motif Score	2.185083333
Cell/Tissue List	HEK293T; H1A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000610413.4; ENST00000311966.9; ENST00000623608.3; ENST00000424141.6; ENST00000390288.6; ENST00000539272.5; ENST00000648304.1; ENST00000479952.5; ENST00000486433.5
External Link	RMBase: m6A_site_193630
mod ID: M6ASITE013480		Click to Show/Hide the Full List
mod site	chr12:56471214-56471215:-		[8]
Sequence	AATGGCTTGCCCCACTCAAAACCATCCCAGCTCTTCACCCA
Motif Score	2.185083333
Cell/Tissue List	hESCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000648304.1; ENST00000311966.9; ENST00000486433.5; ENST00000424141.6; ENST00000623608.3; ENST00000390288.6; ENST00000479952.5; ENST00000610413.4; ENST00000539272.5
External Link	RMBase: m6A_site_193632
mod ID: M6ASITE013481		Click to Show/Hide the Full List
mod site	chr12:56471256-56471257:-		[8]
Sequence	CAGTACAGCTATCCAGAGAGACTGGGCTTCAAGGTACAGCC
Motif Score	3.319380952
Cell/Tissue List	hESCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000648304.1; ENST00000539272.5; ENST00000311966.9; ENST00000479952.5; ENST00000424141.6; ENST00000390288.6; ENST00000610413.4; ENST00000486433.5; ENST00000623608.3
External Link	RMBase: m6A_site_193633
mod ID: M6ASITE013482		Click to Show/Hide the Full List
mod site	chr12:56471272-56471273:-		[9]
Sequence	CCTCAGAGGACACCTGCAGTACAGCTATCCAGAGAGACTGG
Motif Score	2.856142857
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000623608.3; ENST00000610413.4; ENST00000539272.5; ENST00000648304.1; ENST00000390288.6; ENST00000486433.5; ENST00000479952.5; ENST00000424141.6; ENST00000311966.9
External Link	RMBase: m6A_site_193634
mod ID: M6ASITE013483		Click to Show/Hide the Full List
mod site	chr12:56471283-56471284:-		[8]
Sequence	ACAGAGAAGGGCCTCAGAGGACACCTGCAGTACAGCTATCC
Motif Score	3.643047619
Cell/Tissue List	hESCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000610413.4; ENST00000424141.6; ENST00000623608.3; ENST00000486433.5; ENST00000311966.9; ENST00000479952.5; ENST00000539272.5; ENST00000648304.1; ENST00000390288.6
External Link	RMBase: m6A_site_193635
mod ID: M6ASITE013484		Click to Show/Hide the Full List
mod site	chr12:56471472-56471473:-		[9]
Sequence	GGTATGAGCACAGGTCATGGACAGCCCCTGCTCAAGAAAAA
Motif Score	3.643047619
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000648304.1; ENST00000623608.3; ENST00000424141.6; ENST00000610413.4; ENST00000479952.5; ENST00000311966.9; ENST00000486433.5; ENST00000390288.6; ENST00000539272.5
External Link	RMBase: m6A_site_193636
mod ID: M6ASITE013485		Click to Show/Hide the Full List
mod site	chr12:56472251-56472252:-		[10]
Sequence	CTGACACCAGTTCACAAAGAACACCTGTGATTCCAGTCTGA
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000610413.4; ENST00000539272.5; ENST00000486433.5; ENST00000311966.9; ENST00000648304.1; ENST00000390288.6; ENST00000424141.6; ENST00000479952.5; ENST00000623608.3
External Link	RMBase: m6A_site_193639
mod ID: M6ASITE013486		Click to Show/Hide the Full List
mod site	chr12:56474641-56474642:-		[9]
Sequence	ACGGTGGGATCTGCCCCATCACAGGCGAGAGTGTGCTGAGT
Motif Score	2.047297619
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000610413.4; ENST00000486433.5; ENST00000648304.1; ENST00000311966.9; ENST00000539272.5; ENST00000496006.5; ENST00000476991.5; ENST00000623608.3; ENST00000479952.5; ENST00000424141.6
External Link	RMBase: m6A_site_193641
mod ID: M6ASITE013487		Click to Show/Hide the Full List
mod site	chr12:56474876-56474877:-		[11]
Sequence	GTGCTTTCCTAAGGGGGTGGACATGATGGCTGCCCTTGATC
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000648304.1; ENST00000424141.6; ENST00000494474.5; ENST00000476991.5; ENST00000623608.3; ENST00000610413.4; ENST00000479952.5; ENST00000486433.5; ENST00000311966.9; ENST00000496006.5; ENST00000539272.5; ENST00000486896.5
External Link	RMBase: m6A_site_193642
mod ID: M6ASITE013488		Click to Show/Hide the Full List
mod site	chr12:56477994-56477995:-		[9]
Sequence	CCTAGGCACTGACTACGTGCACAAGTTTGTGGGCAAAGAGC
Motif Score	2.830589286
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000494474.5; ENST00000494345.5; ENST00000424141.6; ENST00000539272.5; ENST00000623608.3; ENST00000311966.9; ENST00000648304.1; ENST00000461077.1; ENST00000486433.5; ENST00000486896.5; ENST00000610413.4; ENST00000479952.5
External Link	RMBase: m6A_site_193646
mod ID: M6ASITE013489		Click to Show/Hide the Full List
mod site	chr12:56479166-56479167:-		[11]
Sequence	ATCCAGGTGTGTGAGCAGCAACATTGTGCTCCTGACCCAGG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000483347.1; ENST00000311966.9; ENST00000486896.5; ENST00000539272.5; ENST00000623608.3; ENST00000494474.5; ENST00000648304.1; ENST00000461077.1; ENST00000424141.6; ENST00000479952.5; ENST00000494345.5; ENST00000610413.4; ENST00000486433.5
External Link	RMBase: m6A_site_193650
mod ID: M6ASITE013490		Click to Show/Hide the Full List
mod site	chr12:56479876-56479877:-		[11]
Sequence	TAAAGGCCACTGGACTGCAGACATCAGATCCTCGGCTCCGA
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000494474.5; ENST00000648304.1; ENST00000311966.9; ENST00000486896.5; ENST00000494345.5; ENST00000424141.6; ENST00000461077.1; ENST00000483347.1; ENST00000491880.1; ENST00000610413.4; ENST00000623608.3; ENST00000479952.5; ENST00000471282.5; ENST00000486433.5; ENST00000539272.5
External Link	RMBase: m6A_site_193651
mod ID: M6ASITE013491		Click to Show/Hide the Full List
mod site	chr12:56487560-56487561:-		[12]
Sequence	AGGAGATGCGTGGATGTGGAACAGCCTCCTGCCTCCGGTCC
Motif Score	2.951386905
Cell/Tissue List	HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000483347.1; ENST00000479952.5; ENST00000610413.4; ENST00000648304.1; ENST00000311966.9; ENST00000471282.5; ENST00000623608.3; ENST00000491880.1; ENST00000486433.5; ENST00000486896.5; ENST00000424141.6; ENST00000461077.1; ENST00000494474.5; ENST00000494345.5
External Link	RMBase: m6A_site_193652

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Ref 7	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 8	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 9	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 10	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 11	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 12	Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016 Nov 9;20(5):666-673. doi: 10.1016/j.chom.2016.10.002. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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