m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00724)
Target Name Wee1-like protein kinase (WEE1)
Synonyms
WEE1hu; Wee1A kinase
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Gene Name WEE1
Chromosomal Location 11p15.4
Family Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
Function
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
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Gene ID 7465
Uniprot ID
WEE1_HUMAN
HGNC ID
HGNC:12761
Ensembl Gene ID
ENSG00000166483
KEGG ID
hsa:7465
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
WEE1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Disease
Colorectal cancer [ICD-11: 2B91]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary KIAA1429 plays an oncogenic role in CRC cells by inhibiting the expression of Wee1-like protein kinase (WEE1) in an m6A-independent manner and is associated with poor survival in CRC patients.
Responsed Disease Colorectal cancer [ICD-11: 2B91]
Target Regulation Down regulation