m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00720)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
NELL2
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Fat mass and obesity-associated protein (FTO) [ERASER]
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | FTO upregulated the expression of E2F1 by inhibiting the m6A modification of E2F1. The FTO/E2F1/Protein kinase C-binding protein NELL2 (NELL2) axis modulated NSCLC cell viability, migration, and invasion in vitro as well as affected NSCLC tumor growth and metastasis in vivo. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Non-small-cell lung carcinoma | ICD-11: 2C25.Y | ||
Cell Process | Cell viability | |||
Cell migration | ||||
Cell invasion | ||||
In-vitro Model | NCI-H460 | Lung large cell carcinoma | Homo sapiens | CVCL_0459 |
NCI-H23 | Lung adenocarcinoma | Homo sapiens | CVCL_1547 | |
NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | |
A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 | |
16HBE14o- | Normal | Homo sapiens | CVCL_0112 | |
In-vivo Model | The nude mice were maintained under pathogen-free conditions and kept under timed lighting conditions mandated by the committee with food and water provided ad libitum. For xenograft experiments, nude mice were injected subcutaneously with 5 × 106 cells resuspended in 0.1 mL PBS. When a tumor was palpable, it was measured every 3 days. | |||
Lung cancer [ICD-11: 2C25]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | FTO upregulated the expression of E2F1 by inhibiting the m6A modification of E2F1. The FTO/E2F1/Protein kinase C-binding protein NELL2 (NELL2) axis modulated NSCLC cell viability, migration, and invasion in vitro as well as affected NSCLC tumor growth and metastasis in vivo. | |||
Responsed Disease | Non-small-cell lung carcinoma [ICD-11: 2C25.Y] | |||
Target Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | ||
Target Regulation | Up regulation | |||
Cell Process | Cell viability | |||
Cell migration | ||||
Cell invasion | ||||
In-vitro Model | NCI-H460 | Lung large cell carcinoma | Homo sapiens | CVCL_0459 |
NCI-H23 | Lung adenocarcinoma | Homo sapiens | CVCL_1547 | |
NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | |
A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 | |
16HBE14o- | Normal | Homo sapiens | CVCL_0112 | |
In-vivo Model | The nude mice were maintained under pathogen-free conditions and kept under timed lighting conditions mandated by the committee with food and water provided ad libitum. For xenograft experiments, nude mice were injected subcutaneously with 5 × 106 cells resuspended in 0.1 mL PBS. When a tumor was palpable, it was measured every 3 days. | |||