m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00710)

Target Name	M-phase inducer phosphatase 2 (CDC25B)
Synonyms	Dual specificity phosphatase Cdc25B Click to Show/Hide
Gene Name	CDC25B
Chromosomal Location	20p13
Family	MPI phosphatase family
Function	Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. Click to Show/Hide
Gene ID	994
Uniprot ID	MPIP2_HUMAN
HGNC ID	HGNC:1726
KEGG ID	hsa:994

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

CDC25B can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	HeLa cell line	Homo sapiens
Treatment: METTL3 knockdown HeLa cells Control: HeLa cells		GSE70061
Regulation		logFC: 2.72E+00 p-value: 5.89E-03
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL3 enhanced the m6A modification of M-phase inducer phosphatase 2 (CDC25B) mRNA, which maintained its stability and upregulated its expression, thereby activating G2/M phase of cell cycle and leading to HNSCC malignant progression.
Target Regulation	Up regulation
Responsed Disease	Head and neck squamous carcinoma		ICD-11: 2B6E	Disease Info
Cell Process	Cell proliferation
	Cell migration
	Cell invasion
In-vitro Model	Tu 686	Laryngeal squamous cell carcinoma	Homo sapiens	CVCL_4916
	Tu 212	Head and neck squamous cell carcinoma	Homo sapiens	CVCL_4915
	SAS	Tongue squamous cell carcinoma	Homo sapiens	CVCL_1675
	HUVEC-C	Normal	Homo sapiens	CVCL_2959
	HEp-2	Endocervical adenocarcinoma	Homo sapiens	CVCL_1906
	FaDu	Hypopharyngeal squamous cell carcinoma	Homo sapiens	CVCL_1218
In-vivo Model	Tumour xenograft models were established in nude mice bearing: SAS cells cells stably transfected with METTL3-shRNA and the corresponding control vector. The different HNSCC cells (5 × 10⁶) were subcutaneously injected into the right axilla of nude mice (n = 6 per group).

Head and neck squamous carcinoma [ICD-11: 2B6E]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3 enhanced the m6A modification of M-phase inducer phosphatase 2 (CDC25B) mRNA, which maintained its stability and upregulated its expression, thereby activating G2/M phase of cell cycle and leading to HNSCC malignant progression.
Responsed Disease	Head and neck squamous carcinoma [ICD-11: 2B6E]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Cell Process	Cell proliferation
	Cell migration
	Cell invasion
In-vitro Model	Tu 686	Laryngeal squamous cell carcinoma	Homo sapiens	CVCL_4916
	Tu 212	Head and neck squamous cell carcinoma	Homo sapiens	CVCL_4915
	SAS	Tongue squamous cell carcinoma	Homo sapiens	CVCL_1675
	HUVEC-C	Normal	Homo sapiens	CVCL_2959
	HEp-2	Endocervical adenocarcinoma	Homo sapiens	CVCL_1906
	FaDu	Hypopharyngeal squamous cell carcinoma	Homo sapiens	CVCL_1218
In-vivo Model	Tumour xenograft models were established in nude mice bearing: SAS cells cells stably transfected with METTL3-shRNA and the corresponding control vector. The different HNSCC cells (5 × 10⁶) were subcutaneously injected into the right axilla of nude mice (n = 6 per group).

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00710)

M-phase inducer phosphatase 2 (CDC25B)

N4-acetylcytidine (ac4C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000042		Click to Show/Hide the Full List
mod site	chr20:3801926-3801927:+
Sequence	CCTGCTGTCCCTGCCAGGACCTCGTCATGTACAGCAAGTGC
Cell/Tissue List	DLD1
Seq Type List	acRIP-seq
Transcript ID List	ENST00000480816.5; ENST00000245960.9; ENST00000468979.1; ENST00000340833.4; ENST00000379598.9; ENST00000344256.10; ENST00000467519.5; ENST00000439880.6
External Link	RMBase: ac4C_site_1189
mod ID: AC4SITE000044		Click to Show/Hide the Full List
mod site	chr20:3803441-3803442:+
Sequence	CTGGAACGCGACGCCGAGAGCTTCCTACTGAAGAGCCCCAT
Cell/Tissue List	DLD1
Seq Type List	acRIP-seq
Transcript ID List	ENST00000344256.10; ENST00000340833.4; ENST00000480816.5; ENST00000379598.9; ENST00000439880.6; ENST00000467519.5; ENST00000245960.9
External Link	RMBase: ac4C_site_1190

Adenosine-to-Inosine editing (A-to-I)

In total 3 m6A sequence/site(s) in this target gene
mod ID: A2ISITE010348		Click to Show/Hide the Full List
mod site	chr20:3789519-3789520:+		[2]
Sequence	AGCTGGGATCACAGGTGTACACCACCATACCTGGCTTAGTT
Transcript ID List	ENST00000379598.9; ENST00000344256.10
External Link	RMBase: RNA-editing_site_85215
mod ID: A2ISITE010349		Click to Show/Hide the Full List
mod site	chr20:3790004-3790005:+		[2]
Sequence	TCTCAAAAAAAAAAAAAATTAGCTAGGCATAGTGCCTTGCG
Transcript ID List	ENST00000379598.9; ENST00000344256.10
External Link	RMBase: RNA-editing_site_85216
mod ID: A2ISITE010350		Click to Show/Hide the Full List
mod site	chr20:3791610-3791611:+		[2]
Sequence	GAGGATTGCTTGAACTCAGGAGACAGATGTTGCAGTGAGCC
Transcript ID List	rmsk_5053675; ENST00000379598.9; ENST00000344256.10
External Link	RMBase: RNA-editing_site_85217

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002577		Click to Show/Hide the Full List
mod site	chr20:3796725-3796726:+		[3]
Sequence	ATGCACGACCTCGCCGGGCTCGGCAGGTAGGACACCCCAAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000379598.9; ENST00000245960.9; ENST00000467519.5; ENST00000340833.4; ENST00000439880.6; ENST00000344256.10
External Link	RMBase: m5C_site_28450
mod ID: M5CSITE002578		Click to Show/Hide the Full List
mod site	chr20:3800597-3800598:+
Sequence	CACCTCCCAGCTGGGTGTCCCCAGGCAGGCTGTAGGAGATG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000467519.5; ENST00000344256.10; ENST00000340833.4; ENST00000245960.9; ENST00000379598.9; ENST00000439880.6
External Link	RMBase: m5C_site_28451

N6-methyladenosine (m6A)

In total 47 m6A sequence/site(s) in this target gene
mod ID: M6ASITE051174		Click to Show/Hide the Full List
mod site	chr20:3795858-3795859:+		[4]
Sequence	GACCTTGATTGAGTTAATGAACTTCACGCCTCAGCGTCCAG
Motif Score	3.373380952
Cell/Tissue List	A549; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_5053687; ENST00000245960.9; ENST00000467519.5; ENST00000344256.10; ENST00000379598.9
External Link	RMBase: m6A_site_521460
mod ID: M6ASITE051175		Click to Show/Hide the Full List
mod site	chr20:3795906-3795907:+		[4]
Sequence	AAATGGGGTGTCTAACGCAGACCGTACAGCCCAGCTGGGTT
Motif Score	2.876744048
Cell/Tissue List	A549; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000467519.5; ENST00000245960.9; ENST00000379598.9; ENST00000344256.10
External Link	RMBase: m6A_site_521461
mod ID: M6ASITE051176		Click to Show/Hide the Full List
mod site	chr20:3795933-3795934:+		[4]
Sequence	AGCCCAGCTGGGTTTAGCAAACTTCCGGGAGCCAGTTGGAG
Motif Score	2.627720238
Cell/Tissue List	A549; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000379598.9; ENST00000467519.5; ENST00000245960.9; ENST00000344256.10
External Link	RMBase: m6A_site_521462
mod ID: M6ASITE051177		Click to Show/Hide the Full List
mod site	chr20:3796060-3796061:+		[5]
Sequence	TTGGGAGTGTGGAGCTCCAAACCATGTCGCGAGAGGCGGAT
Motif Score	2.185083333
Cell/Tissue List	CD4T; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000245960.9; ENST00000379598.9; ENST00000467519.5; ENST00000344256.10
External Link	RMBase: m6A_site_521463
mod ID: M6ASITE051178		Click to Show/Hide the Full List
mod site	chr20:3796702-3796703:+		[6]
Sequence	CGGTCACCACCCTCACCCAGACCATGCACGACCTCGCCGGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MM6; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000344256.10; ENST00000467519.5; ENST00000245960.9; ENST00000340833.4; ENST00000379598.9; ENST00000439880.6
External Link	RMBase: m6A_site_521464
mod ID: M6ASITE051179		Click to Show/Hide the Full List
mod site	chr20:3797625-3797626:+		[6]
Sequence	CCTGTTCCCTTCCCAGCGAAACCCCAAAGAGTCAGGTAGGG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; MM6; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000344256.10; ENST00000379598.9; ENST00000340833.4; ENST00000439880.6; ENST00000467519.5; ENST00000245960.9
External Link	RMBase: m6A_site_521465
mod ID: M6ASITE051180		Click to Show/Hide the Full List
mod site	chr20:3797646-3797647:+		[6]
Sequence	CCCCAAAGAGTCAGGTAGGGACCCTGCTCTTCCGCAGCCGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MM6; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000344256.10; ENST00000467519.5; ENST00000245960.9; ENST00000340833.4; ENST00000379598.9; ENST00000439880.6
External Link	RMBase: m6A_site_521466
mod ID: M6ASITE051181		Click to Show/Hide the Full List
mod site	chr20:3798441-3798442:+		[6]
Sequence	GGATTCCCCCAGCCCTATGGACCCCCACATGGCGGAGCAGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000439880.6; ENST00000340833.4; ENST00000379598.9; ENST00000344256.10; ENST00000245960.9; ENST00000467519.5
External Link	RMBase: m6A_site_521467
mod ID: M6ASITE051182		Click to Show/Hide the Full List
mod site	chr20:3798447-3798448:+		[7]
Sequence	CCCCAGCCCTATGGACCCCCACATGGCGGAGCAGACGTGAG
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000245960.9; ENST00000340833.4; ENST00000344256.10; ENST00000379598.9; ENST00000467519.5; ENST00000439880.6
External Link	RMBase: m6A_site_521468
mod ID: M6ASITE051183		Click to Show/Hide the Full List
mod site	chr20:3800293-3800294:+		[6]
Sequence	CTTCTCTGTCCTAGGTTTGAACAGGCCATCCAGGCAGCCAG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000245960.9; ENST00000344256.10; ENST00000379598.9; ENST00000340833.4; ENST00000467519.5; ENST00000439880.6
External Link	RMBase: m6A_site_521469
mod ID: M6ASITE051184		Click to Show/Hide the Full List
mod site	chr20:3800776-3800777:+		[6]
Sequence	CCACAGCCCCGTGCTTCGGAACATCACCAACTCCCAGGCGC
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000344256.10; ENST00000379598.9; ENST00000340833.4; ENST00000467519.5; ENST00000439880.6; ENST00000245960.9
External Link	RMBase: m6A_site_521470
mod ID: M6ASITE051185		Click to Show/Hide the Full List
mod site	chr20:3800854-3800855:+		[6]
Sequence	TGCCAGCAGCTCTGGGGAAGACAAGGAGAATGTGCGCTTCT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; MM6; endometrial; HEC-1-A
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000340833.4; ENST00000245960.9; ENST00000344256.10; ENST00000439880.6; ENST00000467519.5; ENST00000379598.9
External Link	RMBase: m6A_site_521471
mod ID: M6ASITE051186		Click to Show/Hide the Full List
mod site	chr20:3801003-3801004:+		[7]
Sequence	TCAAGATGCCATGGAAGCCCACACATCCCAGCTCCACCCAT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000245960.9; ENST00000340833.4; ENST00000379598.9; ENST00000467519.5; ENST00000439880.6; ENST00000344256.10
External Link	RMBase: m6A_site_521472
mod ID: M6ASITE051187		Click to Show/Hide the Full List
mod site	chr20:3801068-3801069:+		[6]
Sequence	AGGGAAGCCTTTGCCCAGAGACCCAGCTCGGCCCCCGACCT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MM6; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000245960.9; ENST00000340833.4; ENST00000467519.5; ENST00000439880.6; ENST00000344256.10; ENST00000379598.9
External Link	RMBase: m6A_site_521473
mod ID: M6ASITE051188		Click to Show/Hide the Full List
mod site	chr20:3801365-3801366:+		[6]
Sequence	GGAAGATGATGGATTTGTGGACATCCTAGAGAGTGACTTAA
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000245960.9; ENST00000344256.10; ENST00000379598.9; ENST00000340833.4; ENST00000467519.5; ENST00000480816.5; ENST00000439880.6
External Link	RMBase: m6A_site_521474
mod ID: M6ASITE051189		Click to Show/Hide the Full List
mod site	chr20:3801660-3801661:+		[6]
Sequence	CTGTGCTGGAGGATTCCGGGACTGGAGGGGTTTGGCCTATG
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000439880.6; ENST00000344256.10; ENST00000468979.1; ENST00000340833.4; ENST00000379598.9; ENST00000467519.5; ENST00000480816.5; ENST00000245960.9
External Link	RMBase: m6A_site_521475
mod ID: M6ASITE051190		Click to Show/Hide the Full List
mod site	chr20:3801778-3801779:+		[6]
Sequence	TTAGTGCCCCACTGGTCAAGACCTTGGAAAAGGAAGAGGAA
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000344256.10; ENST00000480816.5; ENST00000468979.1; ENST00000340833.4; ENST00000467519.5; ENST00000245960.9; ENST00000379598.9; ENST00000439880.6
External Link	RMBase: m6A_site_521476
mod ID: M6ASITE051191		Click to Show/Hide the Full List
mod site	chr20:3802023-3802024:+		[6]
Sequence	GAGGCTGGAGCGGCCCCAGGACAGGGACACGCCCGTGCAGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; A549; CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000467519.5; ENST00000344256.10; ENST00000439880.6; ENST00000480816.5; ENST00000245960.9; ENST00000379598.9; ENST00000468979.1; ENST00000340833.4
External Link	RMBase: m6A_site_521477
mod ID: M6ASITE051192		Click to Show/Hide the Full List
mod site	chr20:3802029-3802030:+		[6]
Sequence	GGAGCGGCCCCAGGACAGGGACACGCCCGTGCAGAATAAGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T; A549; CD4T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000480816.5; ENST00000245960.9; ENST00000344256.10; ENST00000439880.6; ENST00000379598.9; ENST00000468979.1; ENST00000340833.4; ENST00000467519.5
External Link	RMBase: m6A_site_521478
mod ID: M6ASITE051193		Click to Show/Hide the Full List
mod site	chr20:3802096-3802097:+		[6]
Sequence	GAGCAGCAGGAGGCTGAGGAACCTGTGAGTGCCTTCCTCCT
Motif Score	2.930744048
Cell/Tissue List	HeLa; BGC823; A549; MM6; CD4T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000245960.9; ENST00000467519.5; ENST00000344256.10; ENST00000468979.1; ENST00000480816.5; ENST00000379598.9; ENST00000340833.4; ENST00000439880.6
External Link	RMBase: m6A_site_521479
mod ID: M6ASITE051194		Click to Show/Hide the Full List
mod site	chr20:3802329-3802330:+		[6]
Sequence	GTGTCACGATGAGATCGAGAACCTCCTGGACAGTGACCACC
Motif Score	2.930744048
Cell/Tissue List	HeLa; BGC823; A549; CD4T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000344256.10; ENST00000340833.4; ENST00000480816.5; ENST00000245960.9; ENST00000439880.6; ENST00000467519.5; ENST00000379598.9; ENST00000468979.1
External Link	RMBase: m6A_site_521480
mod ID: M6ASITE051195		Click to Show/Hide the Full List
mod site	chr20:3802338-3802339:+		[6]
Sequence	TGAGATCGAGAACCTCCTGGACAGTGACCACCGAGAGCTGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; BGC823; A549; CD4T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000480816.5; ENST00000467519.5; ENST00000245960.9; ENST00000344256.10; ENST00000468979.1; ENST00000439880.6; ENST00000379598.9; ENST00000340833.4
External Link	RMBase: m6A_site_521481
mod ID: M6ASITE051196		Click to Show/Hide the Full List
mod site	chr20:3802748-3802749:+		[8]
Sequence	GGTTGTTCCCTGGGTGTCAGACCCAAGAGGTGCCTCTCAGT
Motif Score	2.876744048
Cell/Tissue List	BGC823; A549; CD4T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000245960.9; ENST00000379598.9; ENST00000480816.5; ENST00000468979.1; ENST00000344256.10; ENST00000439880.6; ENST00000467519.5; ENST00000340833.4
External Link	RMBase: m6A_site_521482
mod ID: M6ASITE051197		Click to Show/Hide the Full List
mod site	chr20:3802779-3802780:+		[8]
Sequence	GCCTCTCAGTTGCCATGGGAACCAGAACTGAATTTGAAGGC
Motif Score	2.930744048
Cell/Tissue List	BGC823; A549; CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000467519.5; ENST00000245960.9; ENST00000468979.1; ENST00000480816.5; ENST00000344256.10; ENST00000340833.4; ENST00000379598.9; ENST00000495915.1; ENST00000439880.6
External Link	RMBase: m6A_site_521483
mod ID: M6ASITE051198		Click to Show/Hide the Full List
mod site	chr20:3802785-3802786:+		[8]
Sequence	CAGTTGCCATGGGAACCAGAACTGAATTTGAAGGCCAAAGC
Motif Score	3.373380952
Cell/Tissue List	BGC823; A549; CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000340833.4; ENST00000439880.6; ENST00000495915.1; ENST00000480816.5; ENST00000245960.9; ENST00000467519.5; ENST00000379598.9; ENST00000344256.10; ENST00000468979.1
External Link	RMBase: m6A_site_521484
mod ID: M6ASITE051199		Click to Show/Hide the Full List
mod site	chr20:3803138-3803139:+		[7]
Sequence	ATTGACGGGCAAGTTCAGCAACATCGTGGATAAGTTTGTGA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000468979.1; ENST00000439880.6; ENST00000245960.9; ENST00000340833.4; ENST00000480816.5; ENST00000495915.1; ENST00000379598.9; ENST00000467519.5; ENST00000344256.10
External Link	RMBase: m6A_site_521485
mod ID: M6ASITE051200		Click to Show/Hide the Full List
mod site	chr20:3803198-3803199:+		[7]
Sequence	CTATGAATATGAAGGCGGGCACATCAAGGTAAGATGGGGCA
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000495915.1; ENST00000467519.5; ENST00000379598.9; ENST00000344256.10; ENST00000439880.6; ENST00000340833.4; ENST00000480816.5; ENST00000245960.9
External Link	RMBase: m6A_site_521486
mod ID: M6ASITE051201		Click to Show/Hide the Full List
mod site	chr20:3803479-3803480:+		[7]
Sequence	CATCGCGCCCTGTAGCCTGGACAAGAGAGTCATCCTCATTT
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000340833.4; ENST00000245960.9; ENST00000467519.5; ENST00000379598.9; ENST00000344256.10; ENST00000439880.6
External Link	RMBase: m6A_site_521487
mod ID: M6ASITE051202		Click to Show/Hide the Full List
mod site	chr20:3804591-3804592:+		[9]
Sequence	CCGTTTCATCAGGGAACGAGACCGTGCTGTCAACGACTACC
Motif Score	2.876744048
Cell/Tissue List	HepG2; MM6; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000340833.4; ENST00000379598.9; ENST00000439880.6; ENST00000467519.5; ENST00000245960.9; ENST00000344256.10
External Link	RMBase: m6A_site_521488
mod ID: M6ASITE051203		Click to Show/Hide the Full List
mod site	chr20:3804654-3804655:+		[7]
Sequence	GTATATCCTGAAAGGCGGCTACAAGGAGTTCTTCCCTCAGC
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000379598.9; ENST00000439880.6; ENST00000344256.10; ENST00000245960.9; ENST00000467519.5; ENST00000340833.4
External Link	RMBase: m6A_site_521489
mod ID: M6ASITE051204		Click to Show/Hide the Full List
mod site	chr20:3804831-3804832:+		[10]
Sequence	CTGCCCTAGAACTTCTGTGAACCCCAGGACTACCGGCCCAT
Motif Score	2.930744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000439880.6; ENST00000379598.9; ENST00000467519.5; ENST00000245960.9; ENST00000340833.4; ENST00000344256.10
External Link	RMBase: m6A_site_521490
mod ID: M6ASITE051205		Click to Show/Hide the Full List
mod site	chr20:3804839-3804840:+		[6]
Sequence	GAACTTCTGTGAACCCCAGGACTACCGGCCCATGAACCACG
Motif Score	4.065041667
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000344256.10; ENST00000379598.9; ENST00000340833.4; ENST00000245960.9; ENST00000439880.6; ENST00000467519.5
External Link	RMBase: m6A_site_521491
mod ID: M6ASITE051206		Click to Show/Hide the Full List
mod site	chr20:3804854-3804855:+		[6]
Sequence	CCAGGACTACCGGCCCATGAACCACGAGGCCTTCAAGGATG
Motif Score	2.930744048
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000344256.10; ENST00000340833.4; ENST00000439880.6; ENST00000245960.9; ENST00000467519.5; ENST00000379598.9
External Link	RMBase: m6A_site_521492
mod ID: M6ASITE051207		Click to Show/Hide the Full List
mod site	chr20:3804883-3804884:+		[6]
Sequence	CCTTCAAGGATGAGCTAAAGACCTTCCGCCTCAAGACTCGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; Huh7; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000344256.10; ENST00000245960.9; ENST00000439880.6; ENST00000379598.9; ENST00000340833.4; ENST00000467519.5
External Link	RMBase: m6A_site_521493
mod ID: M6ASITE051208		Click to Show/Hide the Full List
mod site	chr20:3804898-3804899:+		[6]
Sequence	TAAAGACCTTCCGCCTCAAGACTCGCAGCTGGGCTGGGGAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; MM6; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000439880.6; ENST00000340833.4; ENST00000344256.10; ENST00000245960.9; ENST00000379598.9; ENST00000467519.5
External Link	RMBase: m6A_site_521494
mod ID: M6ASITE051209		Click to Show/Hide the Full List
mod site	chr20:3804953-3804954:+		[6]
Sequence	GCTCTGTAGCCGGCTGCAGGACCAGTGAGGGGCCTGCGCCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MM6; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000379598.9; ENST00000467519.5; ENST00000439880.6; ENST00000344256.10; ENST00000245960.9; ENST00000340833.4
External Link	RMBase: m6A_site_521495
mod ID: M6ASITE051210		Click to Show/Hide the Full List
mod site	chr20:3805397-3805398:+		[11]
Sequence	GTCAGCTCTCTGCCCTGTGTACTTCCCGGGCCAGGGCTGCC
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000245960.9; ENST00000439880.6; ENST00000379598.9; ENST00000344256.10
External Link	RMBase: m6A_site_521496
mod ID: M6ASITE051211		Click to Show/Hide the Full List
mod site	chr20:3805584-3805585:+		[7]
Sequence	GACTTTACGCCCATCTCAGGACACTTCCGTAGACTGTTTAG
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000379598.9; ENST00000245960.9; ENST00000344256.10; ENST00000439880.6
External Link	RMBase: m6A_site_521497
mod ID: M6ASITE051212		Click to Show/Hide the Full List
mod site	chr20:3805596-3805597:+		[11]
Sequence	ATCTCAGGACACTTCCGTAGACTGTTTAGGTTCCCCTGTCA
Motif Score	3.319380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000439880.6; ENST00000245960.9; ENST00000379598.9; ENST00000344256.10
External Link	RMBase: m6A_site_521498
mod ID: M6ASITE051213		Click to Show/Hide the Full List
mod site	chr20:3805747-3805748:+		[9]
Sequence	CCCAGCCCCTACTGCTGTGAACCCTGGGGCCTGACTGCTCA
Motif Score	2.930744048
Cell/Tissue List	HepG2; A549; MM6; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000379598.9; ENST00000344256.10; ENST00000439880.6; ENST00000245960.9
External Link	RMBase: m6A_site_521499
mod ID: M6ASITE051214		Click to Show/Hide the Full List
mod site	chr20:3805770-3805771:+		[9]
Sequence	CTGGGGCCTGACTGCTCAGAACTTGCTGCTGTCTTGTTGCG
Motif Score	3.373380952
Cell/Tissue List	HEK293T; HepG2; A549; MM6; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000245960.9; ENST00000379598.9; ENST00000344256.10; ENST00000439880.6
External Link	RMBase: m6A_site_521500
mod ID: M6ASITE051215		Click to Show/Hide the Full List
mod site	chr20:3805864-3805865:+		[9]
Sequence	GCAGTGCCTTGCATACCCAAACCAGGTGGGAGCGTTTTGTT
Motif Score	2.185083333
Cell/Tissue List	HEK293T; HepG2; HeLa; U2OS; A549; MM6; Huh7; Jurkat; TREX; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000344256.10; ENST00000245960.9; ENST00000439880.6; ENST00000379598.9
External Link	RMBase: m6A_site_521501
mod ID: M6ASITE051216		Click to Show/Hide the Full List
mod site	chr20:3805932-3805933:+		[4]
Sequence	ATGTGTGCCTATTTGTGTGGACAAAAATATTTACACTTAGG
Motif Score	3.643047619
Cell/Tissue List	HEK293T; HeLa; A549; hESC-HEK293T; HepG2; U2OS; hESCs; LCLs; MM6; Huh7; Jurkat; TREX; NB4
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000344256.10; ENST00000245960.9; ENST00000379598.9; ENST00000439880.6
External Link	RMBase: m6A_site_521502
mod ID: M6ASITE051217		Click to Show/Hide the Full List
mod site	chr20:3805944-3805945:+		[11]
Sequence	TTGTGTGGACAAAAATATTTACACTTAGGGTTTGGAGCTAT
Motif Score	2.07285119
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000245960.9; ENST00000439880.6; ENST00000379598.9; ENST00000344256.10
External Link	RMBase: m6A_site_521503
mod ID: M6ASITE051218		Click to Show/Hide the Full List
mod site	chr20:3805994-3805995:+		[4]
Sequence	AATGTCACAGAAGCAGCTAAACCAAGGACTGAGCACCCTCT
Motif Score	2.185083333
Cell/Tissue List	HEK293T; HeLa; A549; HepG2; U2OS; hESCs; fibroblasts; LCLs; H1299; MM6; Huh7; Jurkat; TREX; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000439880.6; ENST00000379598.9; ENST00000344256.10; ENST00000245960.9
External Link	RMBase: m6A_site_521504
mod ID: M6ASITE051219		Click to Show/Hide the Full List
mod site	chr20:3806001-3806002:+		[4]
Sequence	CAGAAGCAGCTAAACCAAGGACTGAGCACCCTCTGGATTCT
Motif Score	4.065041667
Cell/Tissue List	HEK293T; HeLa; A549; HepG2; U2OS; hESCs; fibroblasts; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; TREX; HEC-1-A; AML
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000344256.10; ENST00000245960.9; ENST00000439880.6; ENST00000379598.9
External Link	RMBase: m6A_site_521505
mod ID: M6ASITE051220		Click to Show/Hide the Full List
mod site	chr20:3806114-3806115:+		[4]
Sequence	AGCACTGAGCAAGTTGAGAAACCAGCATTGTGTCCTGTGGG
Motif Score	2.185083333
Cell/Tissue List	HEK293T; A549; HepG2; LCLs; H1299; Huh7; Jurkat
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000344256.10; ENST00000439880.6; ENST00000379598.9; ENST00000245960.9
External Link	RMBase: m6A_site_521506

Ref 1	METTL3 modulates m6A modification of CDC25B and promotes head and neck squamous cell carcinoma malignant progression. Exp Hematol Oncol. 2022 Mar 14;11(1):14. doi: 10.1186/s40164-022-00256-3.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 4	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 5	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife. 2016 Jul 2;5:e15528. doi: 10.7554/eLife.15528.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer. Mol Cancer. 2019 Oct 13;18(1):142. doi: 10.1186/s12943-019-1065-4.
Ref 9	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 10	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 11	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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