m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00709)
Target Name Ras GTPase-activating-like protein IQGAP1 (IQGAP1)
Synonyms
p195
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Gene Name IQGAP1
Chromosomal Location 15q26.1
Function
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth . May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest.
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Gene ID 8826
Uniprot ID
IQGA1_HUMAN
HGNC ID
HGNC:6110
Ensembl Gene ID
ENSG00000140575
KEGG ID
hsa:8826
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
IQGAP1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Fat mass and obesity-associated protein (FTO) [ERASER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by FTO
Cell Line NB4 cell line Homo sapiens
Treatment: shFTO NB4 cells
Control: shNS NB4 cells
 GSE103494
Regulation
logFC: 6.41E-01
p-value: 2.42E-02
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary AMD1 could stabilize the interaction of Ras GTPase-activating-like protein IQGAP1 (IQGAP1) with FTO, which then promotes FTO expression and increases HCC stemness.
Target Regulation Up regulation
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Pathway Response Ubiquitin mediated proteolysis hsa04120
Cell Process Proteasome pathway degradation
In-vitro Model MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
In-vivo Model For subcutaneous xenotransplanted tumor models, cells were injected subcutaneously (5 × 106 for MHCC97H or 1×106 for PLC cells per mouse).
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary AMD1 could stabilize the interaction of Ras GTPase-activating-like protein IQGAP1 (IQGAP1) with FTO, which then promotes FTO expression and increases HCC stemness.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Ubiquitin mediated proteolysis hsa04120
Cell Process Proteasome pathway degradation
In-vitro Model MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
In-vivo Model For subcutaneous xenotransplanted tumor models, cells were injected subcutaneously (5 × 106 for MHCC97H or 1×106 for PLC cells per mouse).
References
Ref 1 AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation. Clin Transl Med. 2021 Mar;11(3):e352. doi: 10.1002/ctm2.352.