m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00676)

Target Name	ATP-binding cassette sub-family C member 10 (ABCC10)
Synonyms	Multidrug resistance-associated protein 7 Click to Show/Hide
Gene Name	ABCC10
Chromosomal Location	6p21.1
Family	ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Function	ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel. Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP. Click to Show/Hide
Gene ID	89845
Uniprot ID	MRP7_HUMAN
HGNC ID	HGNC:52
KEGG ID	hsa:89845

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

ABCC10 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Browse Drug

Fat mass and obesity-associated protein (FTO) [ERASER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by FTO*
Cell Line	Mouse hippocampus	Mus musculus
Treatment: FTO knockout mice hippocampus Control: Wild type hippocampus		GSE94098
Regulation		logFC: 6.58E-01 p-value: 2.09E-04
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	Not only FTO knockdown enhanced the gefitinib sensitivity of GR cells but also FTO reduction in donor exosomes alleviated the acquired resistance of recipient non-small cell lung cancer PC9 cells. FTO/YTHDF2/ATP-binding cassette sub-family C member 10 (ABCC10) axis played a role in intercellular transmission of GR cell-derived exosome-mediated gefitinib resistance.
Target Regulation	Up regulation
Responsed Disease	Non-small-cell lung carcinoma		ICD-11: 2C25.Y	Disease Info
Responsed Drug	Gefitinib		Approved	Drug Info
Pathway Response	ABC transporters			hsa02010
In-vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
In-vitro Model	NCI-H1975	Lung adenocarcinoma	Homo sapiens	CVCL_1511
In-vivo Model	Mice were randomized into three groups (n = 7/group), 1 × 10⁷ PC9 cells absorbed exosomes were subcutaneously injected into the Bilateral groin of mice. Treatment began 1 week following injection, the mice were intraperitoneally injected with gefitinib (30 mg/kg/day).

YTH domain-containing family protein 2 (YTHDF2) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	Not only FTO knockdown enhanced the gefitinib sensitivity of GR cells but also FTO reduction in donor exosomes alleviated the acquired resistance of recipient non-small cell lung cancer PC9 cells. FTO/YTHDF2/ATP-binding cassette sub-family C member 10 (ABCC10) axis played a role in intercellular transmission of GR cell-derived exosome-mediated gefitinib resistance.
Target Regulation	Down regulation
Responsed Disease	Non-small-cell lung carcinoma		ICD-11: 2C25.Y	Disease Info
Responsed Drug	Gefitinib		Approved	Drug Info
Pathway Response	ABC transporters			hsa02010
In-vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
In-vitro Model	NCI-H1975	Lung adenocarcinoma	Homo sapiens	CVCL_1511
In-vivo Model	Mice were randomized into three groups (n = 7/group), 1 × 10⁷ PC9 cells absorbed exosomes were subcutaneously injected into the Bilateral groin of mice. Treatment began 1 week following injection, the mice were intraperitoneally injected with gefitinib (30 mg/kg/day).

Lung cancer [ICD-11: 2C25]

Disease Info

In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	Not only FTO knockdown enhanced the gefitinib sensitivity of GR cells but also FTO reduction in donor exosomes alleviated the acquired resistance of recipient non-small cell lung cancer PC9 cells. FTO/YTHDF2/ATP-binding cassette sub-family C member 10 (ABCC10) axis played a role in intercellular transmission of GR cell-derived exosome-mediated gefitinib resistance.
Responsed Disease	Non-small-cell lung carcinoma [ICD-11: 2C25.Y]
Target Regulator	Fat mass and obesity-associated protein (FTO)		ERASER	Regulator Info
Target Regulation	Up regulation
Responsed Drug	Gefitinib		Approved	Drug Info
Pathway Response	ABC transporters			hsa02010
In-vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
In-vitro Model	NCI-H1975	Lung adenocarcinoma	Homo sapiens	CVCL_1511
In-vivo Model	Mice were randomized into three groups (n = 7/group), 1 × 10⁷ PC9 cells absorbed exosomes were subcutaneously injected into the Bilateral groin of mice. Treatment began 1 week following injection, the mice were intraperitoneally injected with gefitinib (30 mg/kg/day).
Experiment 2 Reporting the m6A-centered Disease Response				[1]
Response Summary	Not only FTO knockdown enhanced the gefitinib sensitivity of GR cells but also FTO reduction in donor exosomes alleviated the acquired resistance of recipient non-small cell lung cancer PC9 cells. FTO/YTHDF2/ATP-binding cassette sub-family C member 10 (ABCC10) axis played a role in intercellular transmission of GR cell-derived exosome-mediated gefitinib resistance.
Responsed Disease	Non-small-cell lung carcinoma [ICD-11: 2C25.Y]
Target Regulator	YTH domain-containing family protein 2 (YTHDF2)		READER	Regulator Info
Target Regulation	Down regulation
Responsed Drug	Gefitinib		Approved	Drug Info
Pathway Response	ABC transporters			hsa02010
In-vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
In-vitro Model	NCI-H1975	Lung adenocarcinoma	Homo sapiens	CVCL_1511
In-vivo Model	Mice were randomized into three groups (n = 7/group), 1 × 10⁷ PC9 cells absorbed exosomes were subcutaneously injected into the Bilateral groin of mice. Treatment began 1 week following injection, the mice were intraperitoneally injected with gefitinib (30 mg/kg/day).

Gefitinib [Approved]

Drug Info

In total 2 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response				[1]
Response Summary	Not only FTO knockdown enhanced the gefitinib sensitivity of GR cells but also FTO reduction in donor exosomes alleviated the acquired resistance of recipient non-small cell lung cancer PC9 cells. FTO/YTHDF2/ATP-binding cassette sub-family C member 10 (ABCC10) axis played a role in intercellular transmission of GR cell-derived exosome-mediated gefitinib resistance.
Target Regulator	Fat mass and obesity-associated protein (FTO)		ERASER	Regulator Info
Target Regulation	Up regulation
Responsed Disease	Non-small-cell lung carcinoma		ICD-11: 2C25.Y	Disease Info
Pathway Response	ABC transporters			hsa02010
In-vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
In-vitro Model	NCI-H1975	Lung adenocarcinoma	Homo sapiens	CVCL_1511
In-vivo Model	Mice were randomized into three groups (n = 7/group), 1 × 10⁷ PC9 cells absorbed exosomes were subcutaneously injected into the Bilateral groin of mice. Treatment began 1 week following injection, the mice were intraperitoneally injected with gefitinib (30 mg/kg/day).
Experiment 2 Reporting the m6A-centered Drug Response				[1]
Response Summary	Not only FTO knockdown enhanced the gefitinib sensitivity of GR cells but also FTO reduction in donor exosomes alleviated the acquired resistance of recipient non-small cell lung cancer PC9 cells. FTO/YTHDF2/ATP-binding cassette sub-family C member 10 (ABCC10) axis played a role in intercellular transmission of GR cell-derived exosome-mediated gefitinib resistance.
Target Regulator	YTH domain-containing family protein 2 (YTHDF2)		READER	Regulator Info
Target Regulation	Down regulation
Responsed Disease	Non-small-cell lung carcinoma		ICD-11: 2C25.Y	Disease Info
Pathway Response	ABC transporters			hsa02010
In-vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
In-vitro Model	NCI-H1975	Lung adenocarcinoma	Homo sapiens	CVCL_1511
In-vivo Model	Mice were randomized into three groups (n = 7/group), 1 × 10⁷ PC9 cells absorbed exosomes were subcutaneously injected into the Bilateral groin of mice. Treatment began 1 week following injection, the mice were intraperitoneally injected with gefitinib (30 mg/kg/day).

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: Fat mass and obesity-associated protein (FTO)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05240		Crosstalk Info
Epigenetic Regulator	hsa-miR-607
Regulated Target	FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship	ncRNA → m6A
Disease	Non-small cell lung cancer	Disease Info
Drug	Gefitinib	Drug Info
Crosstalk ID: M6ACROT05254		Crosstalk Info
Epigenetic Regulator	hsa_circ_0072309 (Circ_LIFR)
Regulated Target	hsa-miR-607
Crosstalk relationship	ncRNA → m6A
Disease	Non-small cell lung cancer	Disease Info
Drug	Gefitinib	Drug Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00676)

ATP-binding cassette sub-family C member 10 (ABCC10)

Adenosine-to-Inosine editing (A-to-I)

In total 14 m6A sequence/site(s) in this target gene
mod ID: A2ISITE001500		Click to Show/Hide the Full List
mod site	chr6:43429662-43429663:+		[2]
Sequence	GCCTGTAATGCCAGCACTGTAGGAGGCCAGGAGTTCGAGAC
Transcript ID List	ENST00000372515.8; ENST00000443426.2; ENST00000502549.1; ENST00000372530.9; rmsk_1934151
External Link	RMBase: RNA-editing_site_116510
mod ID: A2ISITE001501		Click to Show/Hide the Full List
mod site	chr6:43429700-43429701:+		[2]
Sequence	GACCAGCCTGCCAACGTGGCAGAATGCCATCTCTACTAAAA
Transcript ID List	rmsk_1934151; ENST00000372515.8; ENST00000443426.2; ENST00000372530.9; ENST00000502549.1
External Link	RMBase: RNA-editing_site_116511
mod ID: A2ISITE001502		Click to Show/Hide the Full List
mod site	chr6:43429815-43429816:+		[2]
Sequence	ACTGGAGGTCAGGAGTTTGAAACCAGCCTGGTCAACATGGT
Transcript ID List	ENST00000443426.2; ENST00000372515.8; rmsk_1934151; ENST00000502549.1; ENST00000372530.9
External Link	RMBase: RNA-editing_site_116512
mod ID: A2ISITE001503		Click to Show/Hide the Full List
mod site	chr6:43429816-43429817:+		[3]
Sequence	CTGGAGGTCAGGAGTTTGAAACCAGCCTGGTCAACATGGTG
Transcript ID List	rmsk_1934151; ENST00000443426.2; ENST00000372515.8; ENST00000502549.1; ENST00000372530.9
External Link	RMBase: RNA-editing_site_116513
mod ID: A2ISITE001504		Click to Show/Hide the Full List
mod site	chr6:43429871-43429872:+		[2]
Sequence	ATCGCTTGAACCCAGGAGGCAGAGGTTGTGGTGCGCCAAGA
Transcript ID List	ENST00000443426.2; ENST00000502549.1; ENST00000372515.8; ENST00000372530.9; rmsk_1934151
External Link	RMBase: RNA-editing_site_116514
mod ID: A2ISITE001505		Click to Show/Hide the Full List
mod site	chr6:43429888-43429889:+		[2]
Sequence	GGCAGAGGTTGTGGTGCGCCAAGATTGCACCACTGCACTCC
Transcript ID List	ENST00000502549.1; rmsk_1934151; ENST00000372515.8; ENST00000443426.2; ENST00000372530.9
External Link	RMBase: RNA-editing_site_116515
mod ID: A2ISITE001506		Click to Show/Hide the Full List
mod site	chr6:43429896-43429897:+		[2]
Sequence	TTGTGGTGCGCCAAGATTGCACCACTGCACTCCAGCCTGGA
Transcript ID List	ENST00000372530.9; ENST00000372515.8; ENST00000502549.1; rmsk_1934151; ENST00000443426.2
External Link	RMBase: RNA-editing_site_116516
mod ID: A2ISITE001507		Click to Show/Hide the Full List
mod site	chr6:43429922-43429923:+		[2]
Sequence	GCACTCCAGCCTGGACGACAAAGCGAGACTCTGTCTCAAAA
Transcript ID List	ENST00000372515.8; rmsk_1934151; ENST00000372530.9; ENST00000502549.1; ENST00000443426.2
External Link	RMBase: RNA-editing_site_116517
mod ID: A2ISITE001508		Click to Show/Hide the Full List
mod site	chr6:43430151-43430152:+		[2]
Sequence	CCAGGCTGGAGAGCAGTGGCACGATCTCGGCCCACTGCAAC
Transcript ID List	ENST00000443426.2; ENST00000372515.8; ENST00000502549.1; ENST00000372530.9
External Link	RMBase: RNA-editing_site_116518
mod ID: A2ISITE001509		Click to Show/Hide the Full List
mod site	chr6:43430164-43430165:+		[3]
Sequence	CAGTGGCACGATCTCGGCCCACTGCAACCTCCACCTCTTGG
Transcript ID List	ENST00000443426.2; ENST00000372530.9; ENST00000372515.8; ENST00000502549.1
External Link	RMBase: RNA-editing_site_116519
mod ID: A2ISITE001510		Click to Show/Hide the Full List
mod site	chr6:43430170-43430171:+		[2]
Sequence	CACGATCTCGGCCCACTGCAACCTCCACCTCTTGGGTTCAA
Transcript ID List	ENST00000443426.2; ENST00000372530.9; ENST00000502549.1; ENST00000372515.8
External Link	RMBase: RNA-editing_site_116520
mod ID: A2ISITE001511		Click to Show/Hide the Full List
mod site	chr6:43430295-43430296:+		[2]
Sequence	AGATGGAGTTTCACTGTGTTACACAGGCTGGTCTTGAACTC
Transcript ID List	ENST00000443426.2; ENST00000372515.8; ENST00000502549.1; ENST00000372530.9
External Link	RMBase: RNA-editing_site_116521
mod ID: A2ISITE001512		Click to Show/Hide the Full List
mod site	chr6:43430796-43430797:+		[2]
Sequence	CAGTGGCACGATCTCAGCTCACTGCAACCTCCGCCTCCCAG
Transcript ID List	ENST00000372530.9; ENST00000502549.1; ENST00000372515.8; ENST00000443426.2
External Link	RMBase: RNA-editing_site_116522
mod ID: A2ISITE001513		Click to Show/Hide the Full List
mod site	chr6:43440426-43440427:+		[3]
Sequence	TGTTGTTCATCTCTTTCCTTAGTGCCTACAACAGTACCTAG
Transcript ID List	ENST00000463024.1; ENST00000244533.7; ENST00000372530.9; rmsk_1934171; ENST00000469856.1; ENST00000372515.8
External Link	RMBase: RNA-editing_site_116523

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004013		Click to Show/Hide the Full List
mod site	chr6:43436196-43436197:+		[4]
Sequence	GAGCCTTGTTCTCCTGGGACCCAGTTGGAACCAGCCTGGAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000463024.1; ENST00000372515.8; ENST00000244533.7; ENST00000372530.9
External Link	RMBase: m5C_site_38156
mod ID: M5CSITE004014		Click to Show/Hide the Full List
mod site	chr6:43438007-43438008:+		[4]
Sequence	GCTGCCATCGCTGGAGAGCTCCACAGGTAACCAACCTCCTA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000463024.1; ENST00000372530.9; ENST00000244533.7; ENST00000372515.8
External Link	RMBase: m5C_site_38157

N6-methyladenosine (m6A)

In total 51 m6A sequence/site(s) in this target gene
mod ID: M6ASITE075212		Click to Show/Hide the Full List
mod site	chr6:43427745-43427746:+		[5]
Sequence	GGAGAAACGGGAGGGGAAAAACAGATGGCAAGGTGGGTGAC
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000372515.8; ENST00000372530.9; ENST00000502549.1
External Link	RMBase: m6A_site_718344
mod ID: M6ASITE075213		Click to Show/Hide the Full List
mod site	chr6:43427889-43427890:+		[5]
Sequence	GTTCCAGGGCGGGGCTGGAGACAGGGAGACCCGGCTGGGAA
Motif Score	2.897386905
Cell/Tissue List	HeLa; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372530.9; ENST00000372515.8; ENST00000443426.2; ENST00000502549.1
External Link	RMBase: m6A_site_718345
mod ID: M6ASITE075214		Click to Show/Hide the Full List
mod site	chr6:43427897-43427898:+		[5]
Sequence	GCGGGGCTGGAGACAGGGAGACCCGGCTGGGAAGTGCAGGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372515.8; ENST00000443426.2; ENST00000502549.1; ENST00000372530.9
External Link	RMBase: m6A_site_718346
mod ID: M6ASITE075215		Click to Show/Hide the Full List
mod site	chr6:43432227-43432228:+		[5]
Sequence	TTCCGTCTTCCCGCTGCTAGACCTTCTTCCAGTTGCTTTGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000443426.2; ENST00000372530.9; ENST00000244533.7; ENST00000372515.8
External Link	RMBase: m6A_site_718347
mod ID: M6ASITE075216		Click to Show/Hide the Full List
mod site	chr6:43432267-43432268:+		[5]
Sequence	CCACCAGGGGCAGGCCCAGGACCCATAGGGCTAGAGGTGTT
Motif Score	3.622404762
Cell/Tissue List	HeLa; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372530.9; ENST00000443426.2; ENST00000244533.7; ENST00000372515.8
External Link	RMBase: m6A_site_718348
mod ID: M6ASITE075217		Click to Show/Hide the Full List
mod site	chr6:43432561-43432562:+		[5]
Sequence	GGATGGGCAGCTCCTGGGGGACCACGAGAACCCTGGGCTCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; BGC823; H1A; H1B; A549; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000244533.7; ENST00000372530.9; ENST00000443426.2; ENST00000372515.8
External Link	RMBase: m6A_site_718349
mod ID: M6ASITE075218		Click to Show/Hide the Full List
mod site	chr6:43432570-43432571:+		[5]
Sequence	GCTCCTGGGGGACCACGAGAACCCTGGGCTCAGGAGCCCCT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; BGC823; H1A; H1B; A549; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372530.9; ENST00000372515.8; ENST00000244533.7; ENST00000443426.2
External Link	RMBase: m6A_site_718350
mod ID: M6ASITE075219		Click to Show/Hide the Full List
mod site	chr6:43432609-43432610:+		[5]
Sequence	CTCCTGCCCGAGGATCAAGAACCTGAGGTGGCTGAAGATGG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; BGC823; H1A; H1B; MM6; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372515.8; ENST00000244533.7; ENST00000372530.9; ENST00000443426.2
External Link	RMBase: m6A_site_718351
mod ID: M6ASITE075220		Click to Show/Hide the Full List
mod site	chr6:43432716-43432717:+		[5]
Sequence	AGAGCTCCGGCAGCCTCAGGACATTTGCCGCCTCCCCCACA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372515.8; ENST00000372530.9; ENST00000244533.7; ENST00000443426.2
External Link	RMBase: m6A_site_718352
mod ID: M6ASITE075221		Click to Show/Hide the Full List
mod site	chr6:43432738-43432739:+		[5]
Sequence	ATTTGCCGCCTCCCCCACAGACTGCAGCCAACCTACCTGGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372515.8; ENST00000443426.2; ENST00000244533.7; ENST00000372530.9
External Link	RMBase: m6A_site_718353
mod ID: M6ASITE075222		Click to Show/Hide the Full List
mod site	chr6:43432846-43432847:+		[5]
Sequence	CGGTGCTATCTGGCACTTGGACTGCTGAAGCTGGTGGGGAC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hESCs; GM12878; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372530.9; ENST00000443426.2; ENST00000244533.7; ENST00000372515.8
External Link	RMBase: m6A_site_718354
mod ID: M6ASITE075223		Click to Show/Hide the Full List
mod site	chr6:43432865-43432866:+		[5]
Sequence	GACTGCTGAAGCTGGTGGGGACCATGTTGGGATTCTCAGGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hESCs; GM12878; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000244533.7; ENST00000372515.8; ENST00000372530.9; ENST00000443426.2
External Link	RMBase: m6A_site_718355
mod ID: M6ASITE075224		Click to Show/Hide the Full List
mod site	chr6:43433061-43433062:+		[5]
Sequence	GGCACGGGGGGCTGTGCTGAACATCCTGTACTGCAAGGCTT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1B; GM12878; peripheral-blood; HEK293A-TOA; MSC; TIME; TREX; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000443426.2; ENST00000372530.9; ENST00000372515.8; ENST00000244533.7
External Link	RMBase: m6A_site_718356
mod ID: M6ASITE075225		Click to Show/Hide the Full List
mod site	chr6:43433124-43433125:+		[5]
Sequence	TCCTACTGGGGAGGCCCTGAACCTACTAGGCACTGACTCTG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1B; GM12878; peripheral-blood; HEK293A-TOA; MSC; TIME; TREX; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000244533.7; ENST00000372530.9; ENST00000372515.8; ENST00000443426.2
External Link	RMBase: m6A_site_718357
mod ID: M6ASITE075226		Click to Show/Hide the Full List
mod site	chr6:43434854-43434855:+		[5]
Sequence	TCACTGCCACCAAGGTGAGGACCAGGAAGGAAGGGGACCAG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000244533.7; ENST00000372530.9; ENST00000443426.2; ENST00000372515.8
External Link	RMBase: m6A_site_718358
mod ID: M6ASITE075227		Click to Show/Hide the Full List
mod site	chr6:43434870-43434871:+		[5]
Sequence	GAGGACCAGGAAGGAAGGGGACCAGCATCAAGGAGACTTCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000372530.9; ENST00000443426.2; ENST00000244533.7; ENST00000372515.8
External Link	RMBase: m6A_site_718359
mod ID: M6ASITE075228		Click to Show/Hide the Full List
mod site	chr6:43434885-43434886:+		[5]
Sequence	AGGGGACCAGCATCAAGGAGACTTCAGCGAAGTGAAGACAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; GSC-11; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372530.9; ENST00000244533.7; ENST00000372515.8; ENST00000443426.2
External Link	RMBase: m6A_site_718360
mod ID: M6ASITE075229		Click to Show/Hide the Full List
mod site	chr6:43434902-43434903:+		[5]
Sequence	GAGACTTCAGCGAAGTGAAGACAGAGGCTTGGGCCCTCAGT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; GSC-11; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372530.9; ENST00000244533.7; ENST00000443426.2; ENST00000372515.8
External Link	RMBase: m6A_site_718361
mod ID: M6ASITE075230		Click to Show/Hide the Full List
mod site	chr6:43434979-43434980:+		[5]
Sequence	CATCTCTCAACCAAGGGAAAACTGAAGAAACCTTTTTGTGG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; H1A; H1B; GSC-11; HEK293A-TOA; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000443426.2; ENST00000372515.8; ENST00000244533.7; ENST00000372530.9
External Link	RMBase: m6A_site_718362
mod ID: M6ASITE075231		Click to Show/Hide the Full List
mod site	chr6:43434988-43434989:+		[5]
Sequence	ACCAAGGGAAAACTGAAGAAACCTTTTTGTGGGGGCCTTGG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; H1A; H1B; GSC-11; HEK293A-TOA; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000443426.2; ENST00000244533.7; ENST00000372530.9; ENST00000372515.8
External Link	RMBase: m6A_site_718363
mod ID: M6ASITE075232		Click to Show/Hide the Full List
mod site	chr6:43435847-43435848:+		[5]
Sequence	GGAGGCCAAAGTGTCCTTGGACCGGATCCAGCTTTTCCTCG
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000244533.7; ENST00000463024.1; ENST00000372515.8; ENST00000372530.9
External Link	RMBase: m6A_site_718364
mod ID: M6ASITE075233		Click to Show/Hide the Full List
mod site	chr6:43435877-43435878:+		[5]
Sequence	GCTTTTCCTCGACCTTCCAAACCACAACCCCCAGGCCTACT
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000463024.1; ENST00000244533.7; ENST00000372515.8; ENST00000372530.9
External Link	RMBase: m6A_site_718365
mod ID: M6ASITE075234		Click to Show/Hide the Full List
mod site	chr6:43436194-43436195:+		[5]
Sequence	TGGAGCCTTGTTCTCCTGGGACCCAGTTGGAACCAGCCTGG
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000372530.9; ENST00000463024.1; ENST00000244533.7; ENST00000372515.8
External Link	RMBase: m6A_site_718366
mod ID: M6ASITE075235		Click to Show/Hide the Full List
mod site	chr6:43436205-43436206:+		[5]
Sequence	TCTCCTGGGACCCAGTTGGAACCAGCCTGGAGACCTTCATC
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000372515.8; ENST00000463024.1; ENST00000372530.9; ENST00000244533.7
External Link	RMBase: m6A_site_718367
mod ID: M6ASITE075236		Click to Show/Hide the Full List
mod site	chr6:43436217-43436218:+		[5]
Sequence	CAGTTGGAACCAGCCTGGAGACCTTCATCAGTCATCTCGAA
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000244533.7; ENST00000463024.1; ENST00000372530.9; ENST00000372515.8
External Link	RMBase: m6A_site_718368
mod ID: M6ASITE075237		Click to Show/Hide the Full List
mod site	chr6:43438060-43438061:+		[5]
Sequence	CTTACTTTGTCCTTTAGCAAACACTGAGCCCCTCTTATGTG
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000463024.1; ENST00000244533.7; ENST00000372530.9; ENST00000372515.8
External Link	RMBase: m6A_site_718369
mod ID: M6ASITE075238		Click to Show/Hide the Full List
mod site	chr6:43438085-43438086:+		[5]
Sequence	GAGCCCCTCTTATGTGTTGGACACCTTTTGGGGGTCAGGGG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000372515.8; ENST00000372530.9; ENST00000244533.7; ENST00000463024.1
External Link	RMBase: m6A_site_718370
mod ID: M6ASITE075239		Click to Show/Hide the Full List
mod site	chr6:43438683-43438684:+		[5]
Sequence	TTTGGCCTGGCCACCCAGGAACCCTGGATCCAGTTTGCCAC
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000372515.8; ENST00000372530.9; ENST00000463024.1; ENST00000244533.7
External Link	RMBase: m6A_site_718371
mod ID: M6ASITE075240		Click to Show/Hide the Full List
mod site	chr6:43438712-43438713:+		[5]
Sequence	CCAGTTTGCCACCATCCGAGACAACATCCTCTTTGGGAAGA
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000244533.7; ENST00000463024.1; ENST00000469856.1; ENST00000372515.8; ENST00000372530.9
External Link	RMBase: m6A_site_718372
mod ID: M6ASITE075241		Click to Show/Hide the Full List
mod site	chr6:43438732-43438733:+		[5]
Sequence	ACAACATCCTCTTTGGGAAGACATTTGATGCACAGCTGTAC
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000372515.8; ENST00000244533.7; ENST00000469856.1; ENST00000463024.1; ENST00000372530.9
External Link	RMBase: m6A_site_718373
mod ID: M6ASITE075242		Click to Show/Hide the Full List
mod site	chr6:43441877-43441878:+		[5]
Sequence	TCAGATCCTGCCTGCTGGAGACCAGACAGAGGTGGGGGAGA
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000244533.7; ENST00000463024.1; ENST00000372530.9; ENST00000469856.1; ENST00000372515.8
External Link	RMBase: m6A_site_718374
mod ID: M6ASITE075243		Click to Show/Hide the Full List
mod site	chr6:43441882-43441883:+		[5]
Sequence	TCCTGCCTGCTGGAGACCAGACAGAGGTGGGGGAGAAGGGT
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000372515.8; ENST00000244533.7; ENST00000372530.9; ENST00000469856.1; ENST00000463024.1
External Link	RMBase: m6A_site_718375
mod ID: M6ASITE075244		Click to Show/Hide the Full List
mod site	chr6:43441920-43441921:+		[5]
Sequence	GGTGTCACCCTTAGCGGAGGACAGCGTGCCCGGATTGCCCT
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000463024.1; ENST00000469856.1; ENST00000244533.7; ENST00000372530.9
External Link	RMBase: m6A_site_718376
mod ID: M6ASITE075245		Click to Show/Hide the Full List
mod site	chr6:43443228-43443229:+		[5]
Sequence	CAGGGGATTGTGAAGTACAGACTCTGCCCCCTGCTGCATGT
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000463024.1; ENST00000244533.7; ENST00000372530.9
External Link	RMBase: m6A_site_718377
mod ID: M6ASITE075246		Click to Show/Hide the Full List
mod site	chr6:43443289-43443290:+		[5]
Sequence	CTGCCTCCCGCCTTCACAGAACTGGTGTGAGGAACTGGGAG
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000372530.9; ENST00000244533.7; ENST00000463024.1
External Link	RMBase: m6A_site_718378
mod ID: M6ASITE075247		Click to Show/Hide the Full List
mod site	chr6:43443302-43443303:+		[5]
Sequence	TCACAGAACTGGTGTGAGGAACTGGGAGAACAGGAGGGAAA
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000372530.9; ENST00000463024.1; ENST00000244533.7
External Link	RMBase: m6A_site_718379
mod ID: M6ASITE075248		Click to Show/Hide the Full List
mod site	chr6:43443311-43443312:+		[5]
Sequence	TGGTGTGAGGAACTGGGAGAACAGGAGGGAAAAGGAGTACG
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000463024.1; ENST00000244533.7; ENST00000372530.9
External Link	RMBase: m6A_site_718380
mod ID: M6ASITE075249		Click to Show/Hide the Full List
mod site	chr6:43443890-43443891:+		[6]
Sequence	CTGAGAAAGGCATAGTATAGACTCAGAACAGTCCTCTCCCA
Motif Score	3.319380952
Cell/Tissue List	Jurkat; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244533.7; ENST00000372530.9; ENST00000463024.1
External Link	RMBase: m6A_site_718381
mod ID: M6ASITE075250		Click to Show/Hide the Full List
mod site	chr6:43443897-43443898:+		[7]
Sequence	AGGCATAGTATAGACTCAGAACAGTCCTCTCCCAATCTCCC
Motif Score	2.951386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244533.7; ENST00000372530.9; ENST00000463024.1
External Link	RMBase: m6A_site_718382
mod ID: M6ASITE075251		Click to Show/Hide the Full List
mod site	chr6:43443933-43443934:+		[6]
Sequence	CTCCCCTTCTACCCTCCAGGACCTCCCTCTGAGATTCTGCC
Motif Score	3.622404762
Cell/Tissue List	CD4T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000463024.1; ENST00000244533.7; ENST00000372530.9
External Link	RMBase: m6A_site_718383
mod ID: M6ASITE075252		Click to Show/Hide the Full List
mod site	chr6:43443993-43443994:+		[5]
Sequence	AAAGCCTGGGCTGAGAATGGACAAGAGTCTGACTCAGGTAT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; MM6; CD4T; peripheral-blood; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000463024.1; ENST00000244533.7; ENST00000372530.9
External Link	RMBase: m6A_site_718384
mod ID: M6ASITE075253		Click to Show/Hide the Full List
mod site	chr6:43444179-43444180:+		[5]
Sequence	CACAGCCCAGTCAGTACAGAACCCAGAGAAAACAAAGGAGG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; CD4T; peripheral-blood; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244533.7; ENST00000463024.1; ENST00000372530.9
External Link	RMBase: m6A_site_718385
mod ID: M6ASITE075254		Click to Show/Hide the Full List
mod site	chr6:43444190-43444191:+		[5]
Sequence	CAGTACAGAACCCAGAGAAAACAAAGGAGGGGCTGGAGGAG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; CD4T; peripheral-blood; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000244533.7; ENST00000463024.1; ENST00000372530.9
External Link	RMBase: m6A_site_718386
mod ID: M6ASITE075255		Click to Show/Hide the Full List
mod site	chr6:43444931-43444932:+		[5]
Sequence	GCTCCTCTTTTCCCCTGGAAACCTCTAGTGAGTGGCTGGGG
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000463024.1; ENST00000244533.7; ENST00000372530.9
External Link	RMBase: m6A_site_718387
mod ID: M6ASITE075256		Click to Show/Hide the Full List
mod site	chr6:43446290-43446291:+		[5]
Sequence	CCCTAGGTTTGAGGAGGAGAACCTGCGACTCCTTGAGCTAA
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000372530.9; ENST00000244533.7; ENST00000463024.1; ENST00000372512.2
External Link	RMBase: m6A_site_718388
mod ID: M6ASITE075257		Click to Show/Hide the Full List
mod site	chr6:43446311-43446312:+		[5]
Sequence	CCTGCGACTCCTTGAGCTAAACCAGAGGTGCCAGTTTGCCA
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000372512.2; ENST00000372530.9; ENST00000463024.1; ENST00000244533.7
External Link	RMBase: m6A_site_718389
mod ID: M6ASITE075258		Click to Show/Hide the Full List
mod site	chr6:43446356-43446357:+		[5]
Sequence	TGCCACAATGCAGTGGCTGGACATTCGGCTACAGCTCATGG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000463024.1; ENST00000244533.7; ENST00000372512.2; ENST00000372530.9
External Link	RMBase: m6A_site_718390
mod ID: M6ASITE075259		Click to Show/Hide the Full List
mod site	chr6:43447324-43447325:+		[5]
Sequence	TGGTGAGCAGCTTCACACAGACAGAGGCCATGCTGGTGAGC
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000244533.7; ENST00000372512.2; ENST00000372530.9; ENST00000437104.3; ENST00000463024.1
External Link	RMBase: m6A_site_718391
mod ID: M6ASITE075260		Click to Show/Hide the Full List
mod site	chr6:43447386-43447387:+		[5]
Sequence	ACCTGTGACCTGCCCCAGGAACCCCAGGGCCAGCCACTGCA
Motif Score	2.930744048
Cell/Tissue List	HeLa; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000463024.1; ENST00000244533.7; ENST00000372530.9; ENST00000372512.2; ENST00000437104.3
External Link	RMBase: m6A_site_718392
mod ID: M6ASITE075261		Click to Show/Hide the Full List
mod site	chr6:43449967-43449968:+		[8]
Sequence	TCAGACCGGGTGCTGGTGCTACAAGCGGGGAGAGTGGTAGA
Motif Score	2.078666667
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000505344.1; ENST00000244533.7; ENST00000372530.9; ENST00000463024.1
External Link	RMBase: m6A_site_718393
mod ID: M6ASITE075262		Click to Show/Hide the Full List
mod site	chr6:43450283-43450284:+		[5]
Sequence	CATCCTGAGGCTTCCCCAGAACCAGGCCTCTGCTCTGGCCC
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000244533.7; ENST00000372530.9; ENST00000463024.1; ENST00000505344.1
External Link	RMBase: m6A_site_718394

Ref 1	Exosomal Delivery of FTO Confers Gefitinib Resistance to Recipient Cells through ABCC10 Regulation in an m6A-dependent Manner. Mol Cancer Res. 2021 Apr;19(4):726-738. doi: 10.1158/1541-7786.MCR-20-0541. Epub 2021 Feb 9.
Ref 2	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 3	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 4	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife. 2016 Jul 2;5:e15528. doi: 10.7554/eLife.15528.
Ref 7	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 8	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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