m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00666)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-181d-5p
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Browse Drug
Methyltransferase-like 3 (METTL3) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | METTL3 dependent m6A methylation was upregulated in CRC to promote the processing of miR 181d 5p by DGCR8. This led to increased hsa-miR-181d-5p expression, which inhibited the 5 FU sensitivity of CRC cells by targeting NCALD. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Colorectal cancer | ICD-11: 2B91 | ||
| Responsed Drug | Fluorouracil | Approved | ||
| In-vitro Model | HT29 | Colon cancer | Mus musculus | CVCL_A8EZ |
| HCT 116 | Colon carcinoma | Homo sapiens | CVCL_0291 | |
| In-vivo Model | A tumor-bearing model was established by subcutaneously injecting 100 ul HT29 cells (5×106) followed by an intravenous injection of CAFs-derived exosomes (50 ug/mouse every three days) into the tail vein of the mice. An intraperitoneal injection of 5-FU (50 mg/kg, every week) was administered on day 12. | |||
Colorectal cancer [ICD-11: 2B91]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | METTL3 dependent m6A methylation was upregulated in CRC to promote the processing of miR 181d 5p by DGCR8. This led to increased hsa-miR-181d-5p expression, which inhibited the 5 FU sensitivity of CRC cells by targeting NCALD. | |||
| Responsed Disease | Colorectal cancer [ICD-11: 2B91] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Responsed Drug | Fluorouracil | Approved | ||
| In-vitro Model | HT29 | Colon cancer | Mus musculus | CVCL_A8EZ |
| HCT 116 | Colon carcinoma | Homo sapiens | CVCL_0291 | |
| In-vivo Model | A tumor-bearing model was established by subcutaneously injecting 100 ul HT29 cells (5×106) followed by an intravenous injection of CAFs-derived exosomes (50 ug/mouse every three days) into the tail vein of the mice. An intraperitoneal injection of 5-FU (50 mg/kg, every week) was administered on day 12. | |||
Fluorouracil
[Approved]
| In total 1 item(s) under this drug | ||||
| Experiment 1 Reporting the m6A-centered Drug Response | [1] | |||
| Response Summary | METTL3 dependent m6A methylation was upregulated in CRC to promote the processing of miR 181d 5p by DGCR8. This led to increased hsa-miR-181d-5p expression, which inhibited the 5 FU sensitivity of CRC cells by targeting NCALD. | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Responsed Disease | Colorectal cancer | ICD-11: 2B91 | ||
| In-vitro Model | HT29 | Colon cancer | Mus musculus | CVCL_A8EZ |
| HCT 116 | Colon carcinoma | Homo sapiens | CVCL_0291 | |
| In-vivo Model | A tumor-bearing model was established by subcutaneously injecting 100 ul HT29 cells (5×106) followed by an intravenous injection of CAFs-derived exosomes (50 ug/mouse every three days) into the tail vein of the mice. An intraperitoneal injection of 5-FU (50 mg/kg, every week) was administered on day 12. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 2 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT03574 | ||
| Epigenetic Regulator | Histone acetyltransferase p300 (P300) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Colorectal cancer | |
| Drug | Fluorouracil | |
| Crosstalk ID: M6ACROT03619 | ||
| Epigenetic Regulator | N-lysine methyltransferase SMYD2 (SMYD2) | |
| Regulated Target | Histone H3 lysine 4 trimethylation (H3K4me3) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Colorectal cancer | |
| Drug | Fluorouracil | |
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05615 | ||
| Epigenetic Regulator | hsa-miR-181d-5p | |
| Regulated Target | Neurocalcin-delta (NCALD) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Colorectal cancer | |
| Drug | 5-FU | |