General Information of the m6A Target Gene (ID: M6ATAR00635)
Target Name Transcriptional repressor protein YY1 (YY1)
Synonyms
Delta transcription factor; INO80 complex subunit S; NF-E1; Yin and yang 1; YY-1
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Gene Name YY1
Chromosomal Location 14q32.2
Family YY transcription factor family
Function
Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
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Gene ID 7528
Uniprot ID
TYY1_HUMAN
HGNC ID
HGNC:12856
Ensembl Gene ID
ENSG00000100811
KEGG ID
hsa:7528
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
YY1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Pancreatic islets Mus musculus
Treatment: Mettl3 knockout mice
Control: Mettl3 flox/flox mice
GSE155612
Regulation
logFC: 9.11E-01
p-value: 3.29E-04
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 affected the growth, apoptosis, and stemness of MM cells through accelerating the stability of Transcriptional repressor protein YY1 (YY1) mRNA and the maturation of primary-miR-27a-3p in vitro and in vivo.
Target Regulation Up regulation
Responsed Disease Multiple myeloma ICD-11: 2A83.1
Cell Process Cell apoptosis
In-vitro Model U266 (Human multiple myeloma cells)
RPMI-8226 Plasma cell myeloma Homo sapiens CVCL_0014
NCI-H929 Plasma cell myeloma Homo sapiens CVCL_1600
MM1.S Plasma cell myeloma Homo sapiens CVCL_8792
In-vivo Model BALB/C nude mice (5 weeks old, weighing 18-22 g) were fed in specific pathogen-free facilities and subcutaneously inoculated with U266 cells (1 × 106). The mice were randomly divided into 3 groups with 6 mice per group, when the tumor was measurable. Then, miR-27a-3p mimic or sh-METTL3 was injected intratumorally at an interval of 4 days a total of 4 times. Tumor volume was measured using a digital caliper every week and calculated using the formula V = 1/2 (width2 × length).
Multiple myeloma [ICD-11: 2A83]
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 affected the growth, apoptosis, and stemness of MM cells through accelerating the stability of Transcriptional repressor protein YY1 (YY1) mRNA and the maturation of primary-miR-27a-3p in vitro and in vivo.
Responsed Disease Multiple myeloma [ICD-11: 2A83.1]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
Target Regulation Up regulation
Cell Process Cell apoptosis
In-vitro Model U266 (Human multiple myeloma cells)
RPMI-8226 Plasma cell myeloma Homo sapiens CVCL_0014
NCI-H929 Plasma cell myeloma Homo sapiens CVCL_1600
MM1.S Plasma cell myeloma Homo sapiens CVCL_8792
In-vivo Model BALB/C nude mice (5 weeks old, weighing 18-22 g) were fed in specific pathogen-free facilities and subcutaneously inoculated with U266 cells (1 × 106). The mice were randomly divided into 3 groups with 6 mice per group, when the tumor was measurable. Then, miR-27a-3p mimic or sh-METTL3 was injected intratumorally at an interval of 4 days a total of 4 times. Tumor volume was measured using a digital caliper every week and calculated using the formula V = 1/2 (width2 × length).
References
Ref 1 METTL3 facilitates multiple myeloma tumorigenesis by enhancing YY1 stability and pri-microRNA-27 maturation in m(6)A-dependent manner. Cell Biol Toxicol. 2022 Jan 17. doi: 10.1007/s10565-021-09690-1. Online ahead of print.